ID   LAS1_HUMAN     STANDARD;      PRT;   261 AA.
AC   Q14847; Q96ED2;
DT   15-JUL-1998 (Rel. 36, Created)
DT   15-JUL-1998 (Rel. 36, Last sequence update)
DT   15-JUN-2002 (Rel. 41, Last annotation update)
DE   LIM and SH3 domain protein 1 (LASP-1) (MLN 50).
GN   LASP1 OR MLN50.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Breast carcinoma;
RX   MEDLINE=96039245; PubMed=7490069;
RA   Tomasetto C., Regnier C., Moog-Lutz C., Mattei M.-G., Chenard M.-P.,
RA   Lidereau R., Basset P., Rio M.-C.;
RT   "Identification of four novel human genes amplified and overexpressed
RT   in breast carcinoma and localized to the q11-q21.3 region of
RT   chromosome 17.";
RL   Genomics 28:367-376(1995).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Liver;
RA   Strausberg R.;
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   DOMAINS.
RX   MEDLINE=96033982; PubMed=7589475;
RA   Tomasetto C., Moog-Lutz C., Regnier C.H., Schreiber V., Basset P.,
RA   Rio M.-C.;
RT   "Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by
RT   the association of LIM and SH3 domains.";
RL   FEBS Lett. 373:245-249(1995).
CC   -!- SIMILARITY: CONTAINS 1 LIM DOMAIN. THE LIM DOMAIN BINDS 2 ZINC
CC       IONS.
CC   -!- SIMILARITY: CONTAINS 1 SH3 DOMAIN.
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DR   EMBL; X82456; CAA57833.1; -.
DR   EMBL; BC012460; AAH12460.1; -.
DR   HSSP; P80171; 1ZFO.
DR   SWISS-2DPAGE; Q14847; HUMAN.
DR   MIM; 602920; -.
DR   InterPro; IPR001781; LIM.
DR   InterPro; IPR000900; Nebulin.
DR   InterPro; IPR001452; SH3.
DR   Pfam; PF00018; SH3; 1.
DR   Pfam; PF00412; LIM; 1.
DR   Pfam; PF00880; Nebulin; 2.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   ProDom; PD000066; SH3; 1.
DR   ProDom; PD000094; LIM; 1.
DR   SMART; SM00132; LIM; 1.
DR   SMART; SM00227; NEBU; 2.
DR   SMART; SM00326; SH3; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR   PROSITE; PS50002; SH3; 1.
KW   LIM domain; Metal-binding; Zinc; SH3 domain.
FT   DOMAIN        5     56       LIM.
FT   DOMAIN      202    261       SH3.
FT   DOMAIN      201    204       POLY-GLY.
FT   CONFLICT     79     79       E -> R (IN REF. 2).
FT   CONFLICT    210    210       V -> A (IN REF. 2).
FT   CONFLICT    220    220       E -> A (IN REF. 2).
SQ   SEQUENCE   261 AA;  29717 MW;  3B89B988605B3639 CRC64;
     MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ
     SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI
     KYHEEFEKSR MGPSGGEGME PERRDSQDGS SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA
     QSYGGYKEPA APVSIQRSAP GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM
     YGTVERTGDT GMLPANYVEA I
//