ID   ACM1_HUMAN     STANDARD;      PRT;   460 AA.
AC   P11229;
DT   01-JUL-1989 (Rel. 11, Created)
DT   01-NOV-1990 (Rel. 16, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   Muscarinic acetylcholine receptor M1.
GN   CHRM1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=88096607; PubMed=3697105;
RA   Allard W.J., Sigal I.S., Dixon R.A.F.;
RT   "Sequence of the gene encoding the human M1 muscarinic acetylcholine
RT   receptor.";
RL   Nucleic Acids Res. 15:10604-10604(1987).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=90245684; PubMed=2336407;
RA   Chapman C.G., Browne M.J.;
RT   "Isolation of the human ml (Hml) muscarinic acetylcholine receptor
RT   gene by PCR amplification.";
RL   Nucleic Acids Res. 18:2191-2191(1990).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=88166632; PubMed=3443095;
RA   Peralta E.G., Ashkenazi A., Winslow J.W., Smith D.H.,
RA   Ramachandran J., Capon D.J.;
RT   "Distinct primary structures, ligand-binding properties and tissue-
RT   specific expression of four human muscarinic acetylcholine
RT   receptors.";
RL   EMBO J. 6:3923-3929(1987).
RN   [4]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain;
RA   Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain;
RX   MEDLINE=22388257; PubMed=12477932;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length
RT   human and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [6]
RP   MUTAGENESIS.
RX   MEDLINE=93075202; PubMed=1445347;
RA   Arden J.R., Nagata O., Shockley M.S., Philip M., Lameh J., Sadee W.;
RT   "Mutational analysis of third cytoplasmic loop domains in G-protein
RT   coupling of the HM1 muscarinic receptor.";
RL   Biochem. Biophys. Res. Commun. 188:1111-1115(1992).
CC   -!- FUNCTION: THE MUSCARINIC ACETYLCHOLINE RECEPTOR MEDIATES VARIOUS
CC       CELLULAR RESPONSES, INCLUDING INHIBITION OF ADENYLATE CYCLASE,
CC       BREAKDOWN OF PHOSPHOINOSITIDES & MODULATION OF POTASSIUM CHANNELS
CC       THROUGH THE ACTION OF G PROTEINS. PRIMARY TRANSDUCING EFFECT IS PI
CC       TURNOVER.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; X52068; CAA36291.1; -.
DR   EMBL; X15263; CAA33334.1; -.
DR   EMBL; Y00508; CAA68560.1; -.
DR   EMBL; AF498915; AAM18938.1; -.
DR   EMBL; BC007740; AAH07740.1; -.
DR   EMBL; BC022984; AAH22984.1; -.
DR   PIR; S09508; S09508.
DR   HSSP; P02699; 1BOJ.
DR   Genew; HGNC:1950; CHRM1.
DR   MIM; 118510; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0005624; C:membrane fraction; TAS.
DR   GO; GO:0004981; F:muscarinic acetylcholine receptor activity; TAS.
DR   GO; GO:0007213; P:acetyl choline receptor signaling, muscarin...; TAS.
DR   GO; GO:0008283; P:cell proliferation; TAS.
DR   GO; GO:0007207; P:muscarinic acetyl choline receptor, phospho...; TAS.
DR   GO; GO:0007399; P:neurogenesis; TAS.
DR   GO; GO:0007048; P:oncogenesis; TAS.
DR   GO; GO:0007203; P:phosphatidylinositol-4,5-bisphosphate hydro...; TAS.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; TAS.
DR   GO; GO:0007205; P:protein kinase C activation; TAS.
DR   GO; GO:0006464; P:protein modification; TAS.
DR   GO; GO:0007165; P:signal transduction; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   Postsynaptic membrane; Ionic channel; Glycoprotein; Transmembrane;
KW   Phosphorylation; Multigene family; G-protein coupled receptor.
FT   DOMAIN        1     24       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     25     47       1 (POTENTIAL).
FT   DOMAIN       48     61       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     62     82       2 (POTENTIAL).
FT   DOMAIN       83     99       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    100    121       3 (POTENTIAL).
FT   DOMAIN      122    141       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    142    164       4 (POTENTIAL).
FT   DOMAIN      165    186       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    187    209       5 (POTENTIAL).
FT   DOMAIN      210    366       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    367    387       6 (POTENTIAL).
FT   DOMAIN      388    401       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    402    421       7 (POTENTIAL).
FT   DOMAIN      422    460       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      2      2       N-LINKED (GLCNAC...) (PROBABLE).
FT   CARBOHYD     12     12       N-LINKED (GLCNAC...) (PROBABLE).
FT   DISULFID     98    178       BY SIMILARITY.
FT   MOD_RES     428    428       PHOSPHORYLATION (POTENTIAL).
FT   MOD_RES     451    451       PHOSPHORYLATION (POTENTIAL).
FT   MOD_RES     455    455       PHOSPHORYLATION (POTENTIAL).
FT   MOD_RES     457    457       PHOSPHORYLATION (POTENTIAL).
FT   CONFLICT    173    173       V -> M (IN REF. 3).
SQ   SEQUENCE   460 AA;  51420 MW;  567C20F63541C8D0 CRC64;
     MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF KVNTELKTVN
     NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL WLALDYVASN ASVMNLLLIS
     FDRYFSVTRP LSYRAKRTPR RAALMIGLAW LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI
     QFLSQPIITF GTAMAAFYLP VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS
     SERSQPGAEG SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV
     VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA KRKTFSLVKE
     KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW ELGYWLCYVN STINPMCYAL
     CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG SVHRTPSRQC
//