ID   ACM1_CAEEL     STANDARD;      PRT;   713 AA.
AC   Q18007; Q9NJS7; Q9NJS8; Q9XTK1;
DT   01-NOV-1997 (Rel. 35, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Probable muscarinic acetylcholine receptor gar-1 (G-protein linked
DE   acetylcholine receptor 1).
GN   GAR-1 OR C15B12.5.
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORM A).
RC   STRAIN=Bristol N2;
RX   MEDLINE=99101145; PubMed=9886054;
RA   Lee Y.-S., Park Y.-S., Chang D.-J., Hwang J.M., Min C.K., Kaang B.-K.,
RA   Cho N.J.;
RT   "Cloning and expression of a G protein-linked acetylcholine receptor
RT   from Caenorhabditis elegans.";
RL   J. Neurochem. 72:58-65(1999).
RN   [2]
RP   SEQUENCE FROM N.A., AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   MEDLINE=20145436; PubMed=10679207;
RA   Park Y.-S., Lee Y.-S., Cho N.J., Kaang B.-K.;
RT   "Alternative splicing of gar-1, a Caenorhabditis elegans G-protein-
RT   linked acetylcholine receptor gene.";
RL   Biochem. Biophys. Res. Commun. 268:354-358(2000).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   STRAIN=Bristol N2;
RA   Nhan M.;
RL   Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   REVISIONS, AND ALTERNATIVE SPLICING.
RA   Waterston R.;
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   TISSUE SPECIFICITY.
RX   MEDLINE=20490918; PubMed=11032868;
RA   Lee Y.-S., Park Y.-S., Nam S., Suh S.J., Lee J., Kaang B.-K.,
RA   Cho N.J.;
RT   "Characterization of GAR-2, a novel G protein-linked acetylcholine
RT   receptor from Caenorhabditis elegans.";
RL   J. Neurochem. 75:1800-1809(2000).
CC   -!- FUNCTION: The muscarinic acetylcholine receptor mediates various
CC       cellular responses, including inhibition of adenylate cyclase,
CC       breakdown of phosphoinositides and modulation of potassium
CC       channels through the action of G proteins. Primary transducing
CC       effect is PI turnover.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=B; Synonyms=A, Large;
CC         IsoId=Q18007-1; Sequence=Displayed;
CC       Name=A; Synonyms=B, Medium;
CC         IsoId=Q18007-2; Sequence=VSP_001860;
CC       Name=C; Synonyms=Small;
CC         IsoId=Q18007-3; Sequence=VSP_001860, VSP_001861;
CC   -!- TISSUE SPECIFICITY: Expressed in head region of the larva. In
CC       adults, expression is seen in the periventricularis
CC       magnocellularis (PVM) neuron.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout development from
CC       embryonic to adult stage, highest level seen in early larvae.
CC       Isoform a is the most abundant and isoform c is the least.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
DR   EMBL; AF075245; AAD13747.1; -.
DR   EMBL; AF117300; AAF26201.1; -.
DR   EMBL; AF117301; AAF26202.1; -.
DR   EMBL; U23529; AAL32209.1; -.
DR   EMBL; U23529; AAL32210.1; -.
DR   EMBL; U23529; AAL32211.1; -.
DR   WormPep; C15B12.5a; CE29666.
DR   WormPep; C15B12.5b; CE29667.
DR   WormPep; C15B12.5c; CE29668.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   Receptor; G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Alternative splicing; Multigene family.
FT   DOMAIN        1     20       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     21     41       1 (POTENTIAL).
FT   DOMAIN       42     66       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     67     87       2 (POTENTIAL).
FT   DOMAIN       88    101       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    102    122       3 (POTENTIAL).
FT   DOMAIN      123    144       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    145    165       4 (POTENTIAL).
FT   DOMAIN      166    189       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    190    210       5 (POTENTIAL).
FT   DOMAIN      211    633       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    634    656       6 (POTENTIAL).
FT   DOMAIN      657    670       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    671    693       7 (POTENTIAL).
FT   DOMAIN      694    713       CYTOPLASMIC (POTENTIAL).
FT   DISULFID     99    180       BY SIMILARITY.
FT   CARBOHYD      3      3       N-LINKED (GLCNAC...) (POTENTIAL).
FT   VARSPLIC    275    305       Missing (in isoform A and isoform C).
FT                                /FTId=VSP_001860.
FT   VARSPLIC    533    593       DDSSSEVEGEEKPEVRNNGLKIPQLTVNNENRGETSSQPGR
FT                                DRLAPPNKTDTFLSASGVSR -> E (in isoform C).
FT                                /FTId=VSP_001861.
SQ   SEQUENCE   713 AA;  80404 MW;  114EA5065876DEBF CRC64;
     MPNYTVPPDP ADTSWDSPYS IPVQIVVWII IIVLSLETII GNAMVVMAYR IERNISKQVS
     NRYIVSLAIS DLIIGIEGFP FFTVYVLNGD RWPLGWVACQ TWLFLDYTLC LVSILTVLLI
     TADRYLSVCH TAKYLKWQSP TKTQLLIVMS WLLPAIIFGI MIYGWQAMTG QSTSMSGAEC
     SAPFLSNPYV NMGMYVAYYW TTLVAMLILY KGIHQAAKNL EKKAKAKERR HIALILSQRL
     GTQVGVSLML QSKAEKEKAE EAQKDSGYTS NQAGDANNLR RFGFSEPETS QFRVDPNSNN
     NLNVEGSLNT ENDQNLGVIE EERSGFLSRR ESNESYYPGP HPTAANSRRC SEMEKVSLLS
     ESDGVPSTRP AKSYGRLSLR SRYSASESIT TTHENDEKEV EKADSLQKLF ADDELGSVLN
     FKEEKLKNTD SNNDSDTTSV ILQRSRKYKK NKRPRSSRRS EHSTPRQIAK VKQAEGTAAQ
     LIEESVPDDD QTETIEVKRT DRWVVSMKKR IARALIRRRS TTRPERGSSS NSDDSSSEVE
     GEEKPEVRNN GLKIPQLTVN NENRGETSSQ PGRDRLAPPN KTDTFLSASG VSRKISTIST
     VITREKVISS IFAPIAVFNR GRKQTKAEKR AHKAFRTITF IVGFFAILWS PYYIMATVYG
     FCKGECIPSF LYTLSYYMCY LNSSGNPFAY ALANRQFRSA FMRMFRGNFN KVA
//