ID   ACM2_CAEEL     STANDARD;      PRT;   627 AA.
AC   Q09388; Q09561; Q95WX7;
DT   01-OCT-1996 (Rel. 34, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Probable muscarinic acetylcholine receptor gar-2 (G-protein linked
DE   acetylcholine receptor 2).
GN   GAR-2 OR F47D12.1 OR F47D12.2.
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORM B), AND TISSUE SPECIFICITY.
RC   STRAIN=Bristol N2;
RX   MEDLINE=20490918; PubMed=11032868;
RA   Lee Y.-S., Park Y.-S., Nam S., Suh S.J., Lee J., Kaang B.-K.,
RA   Cho N.J.;
RT   "Characterization of GAR-2, a novel G protein-linked acetylcholine
RT   receptor from Caenorhabditis elegans.";
RL   J. Neurochem. 75:1800-1809(2000).
RN   [2]
RP   SEQUENCE FROM N.A., AND ALTERNATIVE SPLICING.
RX   MEDLINE=21556942; PubMed=11700045;
RA   Suh S.J., Park Y.-S., Lee Y.-S., Cho T.J., Kaang B.-K., Cho N.J.;
RT   "Three functional isoforms of GAR-2, a Caenorhabditis elegans
RT   G-protein-linked acetylcholine receptor, are produced by alternative
RT   splicing.";
RL   Biochem. Biophys. Res. Commun. 288:1238-1243(2001).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   STRAIN=Bristol N2;
RA   Taich A.;
RL   Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   REVISIONS.
RA   Waterston R.;
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The muscarinic acetylcholine receptor mediates various
CC       cellular responses, including inhibition of adenylate cyclase,
CC       breakdown of phosphoinositides and modulation of potassium
CC       channels through the action of G proteins. Primary transducing
CC       effect is pi turnover.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q09388-1; Sequence=Displayed;
CC       Name=b; Synonyms=c;
CC         IsoId=Q09388-2; Sequence=VSP_001862;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Expressed in head region of the larva. In
CC       adults, expression is seen in putative sensory neurons, many cells
CC       of the ventral cord and in the hermaphrodite-specific neuron (HSN)
CC       motor neurons.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout development from
CC       embryonic to adult stage.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; AF272738; AAK94896.1; -.
DR   EMBL; AY053365; AAL15153.1; -.
DR   EMBL; U22831; AAL65783.1; -.
DR   EMBL; U22831; AAL65784.1; -.
DR   WormPep; F47D12.1a; CE30134.
DR   WormPep; F47D12.1b; CE30135.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   Receptor; G-protein coupled receptor; Transmembrane;
KW   Alternative splicing; Multigene family.
FT   DOMAIN        1      9       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     10     30       1 (POTENTIAL).
FT   DOMAIN       31     41       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     42     62       2 (POTENTIAL).
FT   DOMAIN       63     81       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     82    102       3 (POTENTIAL).
FT   DOMAIN      103    122       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    123    143       4 (POTENTIAL).
FT   DOMAIN      144    172       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    173    193       5 (POTENTIAL).
FT   DOMAIN      194    549       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    550    570       6 (POTENTIAL).
FT   DOMAIN      571    586       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    587    609       7 (POTENTIAL).
FT   DOMAIN      610    627       CYTOPLASMIC (POTENTIAL).
FT   DISULFID     79    160       BY SIMILARITY.
FT   VARSPLIC    520    532       Missing (in isoform b).
FT                                /FTId=VSP_001862.
SQ   SEQUENCE   627 AA;  71482 MW;  CB319E3BA8230AE5 CRC64;
     MAVASVLLAL FMLFLSIVTV IGNLAVLLSY YLDKNIRQPT NYFIFSLAIS DLLIGLEGIP
     VYTAFYLNNN EWIWGDVLCD LWLSIDYIVC LASIYTVLGI TVDRYYSVKK PATYRNWRTP
     GRVVLIIIFI WLVPSILFSV SIFGYGTFTG TGRILKETEC YVQFMTNPYL NMGMYISYYW
     TTLFVMLYLY WGIYRAAKKL ALKSDQKTKR LALLTEMRRP EVSVRTSDAG NSSSDSPNDT
     SNSSKCFRTA PPTTTVQTTQ TNVGTPPPVF RNHMTLHNNN MDFTKDNEIV RPPTPPDDNT
     YSNPNFSMIS EQLTNGFSRQ EPSSVIERES TAPCVSPEPS HASLENEFNE NHHAHFKPEL
     SLPFIDADSV SSMVGHDDLR RAMSIRISRS VSMQGTARAT PVIEIVENLE EALKICENLE
     ELREDENKNE EEKQKNGLEN GGMNHVIIAN DEQQPSTSKE SEQKEEMTPE NHDPNEVKVP
     LIAVSRVESV KSTAGGKVRR LITQMRSHSI RSKRKANKNK SVLSALNFFQ RKKEYKSRSE
     NRARKALRTI TFILGSFIIL WTPFYVLATI YGFCETCKAS PSFNTLYTIS YYLCYMNSPL
     NPFCYAMANQ QFKKTLTRIF KGDFRRV
//