ID   ACM1_DROME     STANDARD;      PRT;   722 AA.
AC   P16395;
DT   01-AUG-1990 (Rel. 15, Created)
DT   01-AUG-1990 (Rel. 15, Last sequence update)
DT   01-NOV-1997 (Rel. 35, Last annotation update)
DE   Muscarinic acetylcholine receptor DM1.
GN   ACRC OR MACR-60C.
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7227;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=Oregon-R;
RX   MEDLINE=90046926; PubMed=2510174;
RA   Shapiro R.A., Wakimoto B.T., Subers E.M., Nathanson N.M.;
RT   "Characterization and functional expression in mammalian cells of
RT   genomic and cDNA clones encoding a Drosophila muscarinic
RT   acetylcholine receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:9039-9043(1989).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=90005981; PubMed=2507354;
RA   Onai T., Fitzgerald M.G., Arakawa S., Gocayne J.D., Urquhart D.A.,
RA   Hall L.M., Fraser C.M., McCombie W.R., Venter J.C.;
RT   "Cloning, sequence analysis and chromosome localization of a
RT   Drosophila muscarinic acetylcholine receptor.";
RL   FEBS Lett. 255:219-225(1989).
CC   -!- FUNCTION: THE MUSCARINIC ACETYLCHOLINE RECEPTOR MEDIATES VARIOUS
CC       CELLULAR RESPONSES, INCLUDING INHIBITION OF ADENYLATE CYCLASE,
CC       BREAKDOWN OF PHOSPHOINOSITIDES & MODULATION OF POTASSIUM CHANNELS
CC       THROUGH THE ACTION OF G PROTEINS. PRIMARY TRANSDUCING EFFECT IS
CC       PI TURNOVER.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; M27495; AAA85449.1; -.
DR   EMBL; M23412; AAA28676.1; ALT_INIT.
DR   PIR; A36191; A36191.
DR   PIR; S05661; S05661.
DR   FlyBase; FBgn0000037; mAcR-60C.
DR   GO; GO:0005886; C:plasma membrane; NAS.
DR   GO; GO:0004981; F:muscarinic acetylcholine receptor activity; IDA.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   Postsynaptic membrane; Ionic channel; Glycoprotein; Transmembrane;
KW   Phosphorylation; Multigene family; G-protein coupled receptor.
FT   DOMAIN        1     26       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     27     49       1 (POTENTIAL).
FT   DOMAIN       50     60       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     61     81       2 (POTENTIAL).
FT   DOMAIN       82    100       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    101    120       3 (POTENTIAL).
FT   DOMAIN      121    140       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    141    162       4 (POTENTIAL).
FT   DOMAIN      163    184       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    185    208       5 (POTENTIAL).
FT   DOMAIN      209    634       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    635    656       6 (POTENTIAL).
FT   DOMAIN      657    672       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    673    693       7 (POTENTIAL).
FT   DOMAIN      694    722       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      4      4       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD      7      7       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CONFLICT     75     75       T -> A (IN REF. 2).
FT   CONFLICT    119    119       N -> S (IN REF. 2).
FT   CONFLICT    136    136       G -> R (IN REF. 2).
FT   CONFLICT    147    147       A -> AA (IN REF. 2).
FT   CONFLICT    250    250       P -> G (IN REF. 2).
FT   CONFLICT    346    362       MISSING (IN REF. 2).
FT   CONFLICT    381    381       G -> A (IN REF. 2).
FT   CONFLICT    451    451       T -> A (IN REF. 2).
FT   CONFLICT    606    606       C -> VG (IN REF. 2).
FT   CONFLICT    614    614       P -> AR (IN REF. 2).
FT   CONFLICT    654    656       VLI -> CXS (IN REF. 1).
FT   CONFLICT    688    688       S -> C (IN REF. 2).
FT   CONFLICT    714    722       EGMVRGVYN -> DFYAASTIR (IN REF. 1).
SQ   SEQUENCE   722 AA;  78237 MW;  FB35417CB2202A61 CRC64;
     MYGNQTNGTI GFETKGPRYS LASMVVMGFV AAILSTVTVA GNVMVMISFK IDKQLQTISN
     YFLFSLAIAD FAIGTISMPL FAVTTILGYW PLGPIVCDTW LALDYLASNA SVLNLLIINF
     DRYFSVTRPL TYRAKGTTNR AAVMIGAWGI SLLLWPPWIY SWPYIEGKRT VPKDECYIQF
     IETNQYITFG TALAAFYFPV TIMCFLYWRI WRETKKRQKD LPNLQAGKKD SSKRSNSSDE
     NTVVNHASGP LLAFAQVGGN DHDTWRRPRS ESSADAESVY MTNMVIDSGY HGMHSRKSSI
     KSTNTIKKSY TCFGSIKEWC IAWWHSGRED SDDFAYEQEE PSDLGYATPV TIETPLQSSV
     SRCTSMNVMR DNYSMGGSVS GVRPPSILLS DVSPTPLPRP PLASISQLQE MSAVTASTTA
     NVNTSGNGNG AINNNNNASH NGNGAVNGNG TGNGSGIGLG TTGNATHRDS RTLPVINRIN
     SRSVSQDSVY TILIRLPSDG ASSNAANGGG GGPGAGAAAS ASLSMQGDCA PSIKMIHEDG
     PTTTAAAAPL ASAAATRRPL PSRDSEFSLP LGRRMSHAQH DARLLNAKVI PKQLGKAGGG
     AAGGGCGAHA LMNPNAAKKK KKSQEKRQES KAAKTLSAIL LSFIITWTPY NILVLIKPLT
     TCSDCIPTEL WDFFYALCYI NSTINPMSYA LCNATFRRTY VRILTCKWHT RNREGMVRGV
     YN
//