ID   AA1R_CANFA     STANDARD;      PRT;   326 AA.
AC   P11616;
DT   01-OCT-1989 (Rel. 12, Created)
DT   01-OCT-1989 (Rel. 12, Last sequence update)
DT   01-JUN-1994 (Rel. 29, Last annotation update)
DE   Adenosine A1 receptor.
GN   ADORA1 OR RDC7.
OS   Canis familiaris (Dog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Thyroid;
RX   MEDLINE=89242119; PubMed=2541503;
RA   Libert F., Parmentier M., Lefort A., Dinsart C., van Sande J.,
RA   Maenhaut C., Simons M.-J., Dumont J.E., Vassart G.;
RT   "Selective amplification and cloning of four new members of the G
RT   protein-coupled receptor family.";
RL   Science 244:569-572(1989).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Thyroid;
RX   MEDLINE=90245609; PubMed=2159629;
RA   Libert F., Parmentier M., Lefort A., Dumont J.E., Vassart G.;
RT   "Complete nucleotide sequence of a putative G protein coupled
RT   receptor: RDC7.";
RL   Nucleic Acids Res. 18:1915-1915(1990).
RN   [3]
RP   FUNCTION.
RX   MEDLINE=91266895; PubMed=1646713;
RA   Libert F., Schiffmann S.N., Lefort A., Parmentier M., Gerard C.,
RA   Dumont J.E., Vanderhaeghen J.-J., Vassart G.;
RT   "The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor.";
RL   EMBO J. 10:1677-1682(1991).
CC   -!- FUNCTION: RECEPTOR FOR ADENOSINE. THE ACTIVITY OF THIS RECEPTOR
CC       IS MEDIATED BY G PROTEINS WHICH INHIBIT ADENYLYL CYCLASE.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; X14051; CAA32209.1; -.
DR   PIR; C30341; C30341.
DR   PIR; S12823; S12823.
DR   HSSP; P29274; 1MMH.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Lipoprotein; Palmitate.
FT   DOMAIN        1     10       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     11     33       1 (POTENTIAL).
FT   DOMAIN       34     46       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     47     69       2 (POTENTIAL).
FT   DOMAIN       70     80       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     81    102       3 (POTENTIAL).
FT   DOMAIN      103    123       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    124    146       4 (POTENTIAL).
FT   DOMAIN      147    176       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    177    201       5 (POTENTIAL).
FT   DOMAIN      202    235       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    236    259       6 (POTENTIAL).
FT   DOMAIN      260    267       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    268    292       7 (POTENTIAL).
FT   DOMAIN      293    326       CYTOPLASMIC (POTENTIAL).
FT   DISULFID     80    169       BY SIMILARITY.
FT   CARBOHYD    159    159       N-LINKED (GLCNAC...) (POTENTIAL).
FT   LIPID       309    309       PALMITATE (POTENTIAL).
SQ   SEQUENCE   326 AA;  36399 MW;  D55FCE6914AEA50E CRC64;
     MPPAISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA
     LVIPLAILIN IGPRTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKTVVT
     PRRAAVAIAG CWILSFVVGL TPLFGWNRLG EAQRAWAANG SGGEPVIKCE FEKVISMEYM
     VYFNFFVWVL PPLLLMVLIY LEVFYLIRRQ LGKKVSASSG DPQKYYGKEL KIAKSLALIL
     FLFALSWLPL HILNCITLFC PSCRKPSILM YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL
     KIWNDHFRCQ PTPPVDEDPP EEAPHD
//