ID   P2YR_HUMAN     STANDARD;      PRT;   373 AA.
AC   P47900;
DT   01-FEB-1996 (Rel. 33, Created)
DT   01-FEB-1996 (Rel. 33, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   P2Y purinoceptor 1 (ATP receptor) (P2Y1) (Purinergic receptor).
GN   P2RY1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Placenta;
RX   MEDLINE=96257237; PubMed=8666290;
RA   Leon C., Vial C., Cazenave J.-P., Gachet C.;
RT   "Cloning and sequencing of a human cDNA encoding endothelial P2Y1
RT   purinoceptor.";
RL   Gene 171:295-297(1996).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96158962; PubMed=8579591;
RA   Ayyanathan K., Tania W., Harbansjit S., Raghbir A.S., Barnard E.A.,
RA   Kunapuli S.P.;
RT   "Cloning and chromosomal localization of the human P2Y1
RT   purinoceptor.";
RL   Biochem. Biophys. Res. Commun. 218:783-788(1996).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96205320; PubMed=8630005;
RA   Janssens R., Communi D., Pirotton S., Samson M., Parmentier M.,
RA   Boeynaems J.M.;
RT   "Cloning and tissue distribution of the human P2Y1 receptor.";
RL   Biochem. Biophys. Res. Commun. 221:588-593(1996).
RN   [4]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Blood;
RA   Leon C., Vial C., Weber J., Cazenave J.-P., Gacher C.;
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   SEQUENCE OF 95-373 FROM N.A., FUNCTION, AND INHIBITION STUDIES.
RC   TISSUE=Platelet;
RX   MEDLINE=98113162; PubMed=9442040;
RA   Jin J., Daniel J.L., Kunapuli S.P.;
RT   "Molecular basis for ADP-induced platelet activation. II. The P2Y1
RT   receptor mediates ADP-induced intracellular calcium mobilization and
RT   shape change in platelets.";
RL   J. Biol. Chem. 273:2030-2034(1998).
CC   -!- FUNCTION: RECEPTOR FOR EXTRACELLULAR ADENINE NUCLEOTIDES SUCH AS
CC       ATP AND ADP. IN PLATELETS BINDING TO ADP LEADS TO MOBILIZATION OF
CC       INTRACELLULAR CALCIUM IONS VIA ACTIVATION OF PHOSPHOLIPASE C, A
CC       CHANGE IN PLATELET SHAPE, AND PROBABLY TO PLATELET AGGREGATION.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- INDUCTION: REPRESSED BY THE P2Y1 RECEPTOR-SPECIFIC ANTAGONISTS
CC       A3P5PS, A3P5P AND A2P5P. THESE INHIBIT CALCIUM ION MOBILIZATION
CC       AND SHAPE CHANGE IN PLATELETS.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; Z49205; CAA89066.1; -.
DR   EMBL; U42030; AAA97873.1; -.
DR   EMBL; U42029; AAA97872.1; -.
DR   EMBL; S81950; AAB47091.1; -.
DR   EMBL; AJ006945; CAA07339.1; -.
DR   EMBL; AF018284; AAB94556.1; -.
DR   HSSP; P34996; 1DDD.
DR   Genew; HGNC:8539; P2RY1.
DR   MIM; 601167; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004872; F:receptor activity; TAS.
DR   GO; GO:0007200; P:G-protein signaling, coupled to IP3 second ...; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein; Platelet;
KW   Blood coagulation.
FT   DOMAIN        1     52       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     53     74       1 (POTENTIAL).
FT   DOMAIN       75     87       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     88    109       2 (POTENTIAL).
FT   DOMAIN      110    126       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    127    147       3 (POTENTIAL).
FT   DOMAIN      148    166       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    167    188       4 (POTENTIAL).
FT   DOMAIN      189    218       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    219    238       5 (POTENTIAL).
FT   DOMAIN      239    265       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    266    285       6 (POTENTIAL).
FT   DOMAIN      286    303       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    304    328       7 (POTENTIAL).
FT   DOMAIN      329    373       CYTOPLASMIC (POTENTIAL).
FT   DISULFID    124    202       BY SIMILARITY.
FT   CARBOHYD     11     11       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     27     27       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    113    113       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    197    197       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CONFLICT    138    138       MISSING (IN REF. 1).
SQ   SEQUENCE   373 AA;  42071 MW;  4DC7C668B4145392 CRC64;
     MTEVLWPAVP NGTDAAFLAG PGSSWGNSTV ASTAAVSSSF KCALTKTGFQ FYYLPAVYIL
     VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY VLTLPALIFY YFNKTDWIFG
     DAMCKLQRFI FHVNLYGSIL FLTCISAHRY SGVVYPLKSL GRLKKKNAIC ISVLVWLIVV
     VAISPILFYS GTGVRKNKTI TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI
     VRALIYKDLD NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPAMCAFND
     RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL QSKSEDMTLN
     ILPEFKQNGD TSL
//