ID   L4R1_HUMAN     STANDARD;      PRT;   352 AA.
AC   Q15722; Q13305; Q92641; Q9BSU5;
DT   01-NOV-1997 (Rel. 35, Created)
DT   15-JUL-1998 (Rel. 36, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   Leukotriene B4 receptor 1 (LTB4-R) (P2Y purinoceptor 7) (P2Y7)
DE   (Chemoattractant receptor-like 1).
GN   LTB4R OR P2RY7 OR GPR16 OR CMKRL1 OR BLT OR BLT1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96324902; PubMed=8702478;
RA   Akbar G.K.M., Dasari V.R., Webb T., Ayyanathan K.,
RA   Pillarisetti K., Sandhu A.K., Athwal R.S., Daniel J.L., Ashby B.,
RA   Barnard E.A., Kunapuli S.P.;
RT   "Molecular cloning of a novel P2 purinoceptor from human
RT   erythroleukemia cells.";
RL   J. Biol. Chem. 271:18363-18367(1996).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96145150; PubMed=8558062;
RA   Raport C.J., Schweickart V.L., Chantry D., Eddy R.L. Jr., Shows T.B.,
RA   Godiska R., Gray P.W.;
RT   "New members of the chemokine receptor gene family.";
RL   J. Leukoc. Biol. 59:18-23(1996).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=97320501; PubMed=9177352;
RA   Yokomizo T., Izumi T., Chang K., Takuwa Y., Shimizu T.;
RT   "A G-protein-coupled receptor for leukotriene B4 that mediates
RT   chemotaxis.";
RL   Nature 387:620-624(1997).
RN   [4]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=97079680; PubMed=8921391;
RA   Owman C.S.O., Nilsson C., Lolait S.J.;
RT   "Cloning of cDNA encoding a putative chemoattractant receptor.";
RL   Genomics 37:187-194(1996).
RN   [5]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=20394048; PubMed=10934229;
RA   Kato K., Yokomizo T., Izumi T., Shimizu T.;
RT   "Cell-specific transcriptional regulation of human leukotriene B(4)
RT   receptor gene.";
RL   J. Exp. Med. 192:413-420(2000).
RN   [6]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Lung;
RX   MEDLINE=22388257; PubMed=12477932;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length
RT   human and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: Receptor for extracellular ATP > UTP AND ADP. The
CC       activity of this receptor is mediated by G proteins which activate
CC       a phosphatidylinositol-calcium second messenger system. May be the
CC       cardiac P2Y receptor involved in the regulation of cardiac muscle
CC       contraction through modulation of L-type calcium currents. Is a
CC       receptor for leukotriene B4, a potent chemoattractant involved in
CC       inflammation and immumne response.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed at highest levels in heart, skeletal
CC       muscle and at lower levels in brain and liver. High level of
CC       expression in lymphoid tissues.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; U41070; AAC50628.1; -.
DR   EMBL; U33448; AAB16747.1; ALT_INIT.
DR   EMBL; D89079; BAA20424.1; -.
DR   EMBL; D89078; BAA20423.1; -.
DR   EMBL; X98356; CAA67001.1; -.
DR   EMBL; AB008193; BAB00611.1; -.
DR   EMBL; BC004545; AAH04545.1; -.
DR   Genew; HGNC:6713; LTB4R.
DR   MIM; 601531; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004974; F:leukotriene receptor activity; TAS.
DR   GO; GO:0000166; F:nucleotide binding activity; TAS.
DR   GO; GO:0007200; P:G-protein signaling, coupled to IP3 second ...; TAS.
DR   GO; GO:0006955; P:immune response; TAS.
DR   GO; GO:0006954; P:inflammatory response; TAS.
DR   GO; GO:0006936; P:muscle contraction; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR003983; LTB1_rec.
DR   InterPro; IPR003981; LTB_rec.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01477; LTB1RECEPTOR.
DR   PRINTS; PR01476; LTBRECEPTOR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein.
FT   DOMAIN        1     19       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     20     42       1 (POTENTIAL).
FT   DOMAIN       43     54       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     55     75       2 (POTENTIAL).
FT   DOMAIN       76     91       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     92    113       3 (POTENTIAL).
FT   DOMAIN      114    138       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    139    159       4 (POTENTIAL).
FT   DOMAIN      160    178       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    179    199       5 (POTENTIAL).
FT   DOMAIN      200    221       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    222    242       6 (POTENTIAL).
FT   DOMAIN      243    268       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    269    289       7 (POTENTIAL).
FT   DOMAIN      290    352       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      2      2       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    164    164       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CONFLICT    246    246       G -> R (IN REF. 4).
FT   CONFLICT    272    272       A -> V (IN REF. 1).
FT   CONFLICT    293    293       L -> V (IN REF. 1).
FT   CONFLICT    346    346       L -> F (IN REF. 6).
SQ   SEQUENCE   352 AA;  37557 MW;  5A7BFC0A659AC81C CRC64;
     MNTTSSAAPP SLGVEFISLL AIILLSVALA VGLPGNSFVV WSILKRMQKR SVTALMVLNL
     ALADLAVLLT APFFLHFLAQ GTWSFGLAGC RLCHYVCGVS MYASVLLITA MSLDRSLAVA
     RPFVSQKLRT KAMARRVLAG IWVLSFLLAT PVLAYRTVVP WKTNMSLCFP RYPSEGHRAF
     HLIFEAVTGF LLPFLAVVAS YSDIGRRLQA RRFRRSRRTG RLVVLIILTF AAFWLPYHVV
     NLAEAGRALA GQAAGLGLVG KRLSLARNVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
     VAKLLEGTGS EASSTRRGGS LGQTARSGPA ALEPGPSESL TASSPLKLNE LN
//