ID   L4R2_HUMAN     STANDARD;      PRT;   389 AA.
AC   Q9NPC1; Q9NPE5;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Leukotriene B4 receptor 2 (LTB4-R2) (Seven transmembrane receptor
DE   BLTR2) (Leukotriene B4 receptor BLT2) (LTB4 receptor JULF2).
GN   LTB4R2 OR BLT2R OR BLTR2.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=20374475; PubMed=10913346;
RA   Tryselius Y., Nilsson N.E., Kotarsky K., Olde B., Owman C.;
RT   "Cloning and characterization of cDNA encoding a novel human
RT   leukotriene B4 receptor.";
RL   Biochem. Biophys. Res. Commun. 274:377-382(2000).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=20394049; PubMed=10934230;
RA   Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T.;
RT   "A second leukotriene B4 receptor, BLT2: a new therapeutic target in
RT   inflammation and immunological disorders.";
RL   J. Exp. Med. 192:421-432(2000).
RN   [3]
RP   SEQUENCE FROM N.A.
RA   Volpe F., Patel K., Barnes A., Sanseau P., Cousens D., Green A.,
RA   Marshall F.;
RT   "Identification and characterisation of a novel LTB4 receptor.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   SEQUENCE OF 32-389 FROM N.A.
RX   MEDLINE=20576218; PubMed=11006272;
RA   Wang S., Gustafson E., Pang L., Qiao X., Behan J., Maguire M.,
RA   Bayne M., Laz T.;
RT   "A novel hepatointestinal leukotriene B4 receptor: cloning and
RT   functional characterization.";
RL   J. Biol. Chem. 275:40686-40694(2000).
RN   [5]
RP   SEQUENCE OF 32-389 FROM N.A.
RX   MEDLINE=20418070; PubMed=10889186;
RA   Kamohara M., Takasaki J., Matsumoto M., Saito T., Ohishi T., Ishii H.,
RA   Furuichi K.;
RT   "Molecular cloning and characterization of another leukotriene B4
RT   receptor.";
RL   J. Biol. Chem. 275:27000-27004(2000).
RN   [6]
RP   SEQUENCE OF 32-389 FROM N.A.
RX   MEDLINE=22040266; PubMed=12044878;
RA   Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT   "Identification of G protein-coupled receptor genes from the human
RT   genome sequence.";
RL   FEBS Lett. 520:97-101(2002).
CC   -!- FUNCTION: Low-afinity receptor for leukotrienes including
CC       leukotriene B4. Mediates chemotaxis of granulocytes and
CC       macrophages. The response is mediated via G-proteins that activate
CC       a phosphatidylinositol-calcium second messenger system. The rank
CC       order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 >
CC       LTB5 > LTB3.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: Widely expressed.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-32 is the initiator.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
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CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
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DR   EMBL; AF277230; AAF81261.1; -.
DR   EMBL; AB029892; BAA99553.1; -.
DR   EMBL; AB008193; BAB00610.1; ALT_INIT.
DR   EMBL; AJ278605; CAB96134.1; -.
DR   EMBL; AF308571; AAG40857.1; -.
DR   EMBL; AB044402; BAA99539.1; -.
DR   EMBL; AB083604; BAB89317.1; -.
DR   Genew; HGNC:19260; LTB4R2.
DR   MIM; 605773; -.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR003982; LTB2_rec.
DR   InterPro; IPR003981; LTB_rec.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01478; LTB2RECEPTOR.
DR   PRINTS; PR01476; LTBRECEPTOR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein.
FT   DOMAIN        1     55       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     56     76       1 (POTENTIAL).
FT   DOMAIN       77     91       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     92    112       2 (POTENTIAL).
FT   DOMAIN      113    127       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    128    148       3 (POTENTIAL).
FT   DOMAIN      149    172       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    173    193       4 (POTENTIAL).
FT   DOMAIN      194    216       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    217    237       5 (POTENTIAL).
FT   DOMAIN      238    256       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    257    277       6 (POTENTIAL).
FT   DOMAIN      278    306       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    307    327       7 (POTENTIAL).
FT   DOMAIN      328    389       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     41     41       N-LINKED (GLCNAC...) (POTENTIAL).
SQ   SEQUENCE   389 AA;  41524 MW;  8D6BC5A73A42F544 CRC64;
     MAPSHRASQV GFCPTPERPL WRLPPTCRPR RMSVCYRPPG NETLLSWKTS RATGTAFLLL
     AALLGLPGNG FVVWSLAGWR PARGRPLAAT LVLHLALADG AVLLLTPLFV AFLTRQAWPL
     GQAGCKAVYY VCALSMYASV LLTGLLSLQR CLAVTRPFLA PRLRSPALAR RLLLAVWLAA
     LLLAVPAAVY RHLWRDRVCQ LCHPSPVHAA AHLSLETLTA FVLPFGLMLG CYSVTLARLR
     GARWGSGRHG ARVGRLVSAI VLAFGLLWAP YHAVNLLQAV AALAPPEGAL AKLGGAGQAA
     RAGTTALAFF SSSVNPVLYV FTAGDLLPRA GPRFLTRLFE GSGEARGGGR SREGTMELRT
     TPQLKVVGQG RGNGDPGGGM EKDGPEWDL
//