ID   A1AA_BOVIN     STANDARD;      PRT;   466 AA.
AC   P18130;
DT   01-NOV-1990 (Rel. 16, Created)
DT   01-NOV-1990 (Rel. 16, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha-1C
DE   adrenergic receptor).
GN   ADRA1A OR ADRA1C.
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea;
OC   Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain;
RX   MEDLINE=90243698; PubMed=1970822;
RA   Schwinn D.A., Lomasney J.W., Lorenz W., Szklut P.J., Fremeau R.T. Jr.,
RA   Yang-Feng T.L., Caron M.G., Lefkowitz R.J., Cotecchia S.;
RT   "Molecular cloning and expression of the cDNA for a novel alpha 1-
RT   adrenergic receptor subtype.";
RL   J. Biol. Chem. 265:8183-8189(1990).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=92087349; PubMed=1966743;
RA   Schwinn D.A., Cotecchia S., Lorenz W., Caron M.G., Lefkowitz R.J.;
RT   "The alpha 1C-adrenergic receptor: a new member in the alpha 1-
RT   adrenergic receptor family.";
RL   Trans. Assoc. Am. Physicians 103:112-118(1990).
CC   -!- FUNCTION: THIS ALPHA-ADRENERGIC RECEPTOR MEDIATES ITS ACTION BY
CC       ASSOCIATION WITH G PROTEINS THAT ACTIVATE A PHOSPHATIDYLINOSITOL-
CC       CALCIUM SECOND MESSENGER SYSTEM. ITS EFFECT IS MEDIATED BY G(Q)
CC       AND G(11) PROTEINS.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; J05426; AAA30374.1; -.
DR   PIR; A35375; A35375.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Multigene family; Phosphorylation; Lipoprotein; Palmitate.
FT   DOMAIN        1     27       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     28     51       1 (POTENTIAL).
FT   DOMAIN       52     64       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     65     88       2 (POTENTIAL).
FT   DOMAIN       89     99       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    100    122       3 (POTENTIAL).
FT   DOMAIN      123    143       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    144    167       4 (POTENTIAL).
FT   DOMAIN      168    181       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    182    205       5 (POTENTIAL).
FT   DOMAIN      206    273       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    274    297       6 (POTENTIAL).
FT   DOMAIN      298    305       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    306    329       7 (POTENTIAL).
FT   DOMAIN      330    466       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      7      7       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     13     13       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     22     22       N-LINKED (GLCNAC...) (POTENTIAL).
FT   MOD_RES     215    215       PHOSPHORYLATION (BY PKA) (POTENTIAL).
FT   DISULFID     99    176       BY SIMILARITY.
FT   LIPID       345    345       PALMITATE (POTENTIAL).
SQ   SEQUENCE   466 AA;  51466 MW;  77635153B39E85EC CRC64;
     MVFLSGNASD SSNCTHPPPP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV
     THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN VWAAVDVLCC TASIMGLCII
     SIDRYIGVSY PLRYPTIVTQ KRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE
     EPGYVLFSAL GSFYVPLTII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN
     AQVGGSGVTS AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD
     FRPSETVFKI AFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLRRKQ SSKHTLGYTL
     HAPSHVLEGQ HKDLVRIPVG SAETFYKISK TDGVCEWKIF SSLPRGSARM AVARDPSACT
     TARVRSKSFL QVCCCLGPST PSHGENHQIP TIKIHTISLS ENGEEV
//