ID   A1AA_CANFA     STANDARD;      PRT;   295 AA.
AC   O77621;
DT   15-JUL-1999 (Rel. 38, Created)
DT   15-JUL-1999 (Rel. 38, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha-1C
DE   adrenergic receptor) (Fragment).
GN   ADRA1A OR ADRA1C.
OS   Canis familiaris (Dog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Prostate;
RX   MEDLINE=20501174; PubMed=11046098;
RA   Argyle S.A., McGrath J.C.;
RT   "An alpha(1A)/alpha(1L)-adrenoceptor mediates contraction of canine
RT   subcutaneous resistance arteries.";
RL   J. Pharmacol. Exp. Ther. 295:627-633(2000).
CC   -!- FUNCTION: THIS ALPHA-ADRENERGIC RECEPTOR MEDIATES ITS ACTION BY
CC       ASSOCIATION WITH G PROTEINS THAT ACTIVATE A PHOSPHATIDYLINOSITOL-
CC       CALCIUM SECOND MESSENGER SYSTEM. ITS EFFECT IS MEDIATED BY G(Q)
CC       AND G(11) PROTEINS.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- PTM: CARBOXYL-TERMINAL SER OR THR RESIDUES MAY BE PHOSPHORYLATED
CC       (BY SIMILARITY).
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; AF068283; AAC23861.1; -.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Multigene family; Phosphorylation.
FT   DOMAIN        1     27       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     28     51       1 (POTENTIAL).
FT   DOMAIN       52     64       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     65     88       2 (POTENTIAL).
FT   DOMAIN       89     99       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    100    122       3 (POTENTIAL).
FT   DOMAIN      123    143       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    144    167       4 (POTENTIAL).
FT   DOMAIN      168    181       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    182    205       5 (POTENTIAL).
FT   DOMAIN      206    273       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    274   >295       6 (POTENTIAL).
FT   CARBOHYD      7      7       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     13     13       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     22     22       N-LINKED (GLCNAC...) (POTENTIAL).
FT   DISULFID     99    176       BY SIMILARITY.
FT   MOD_RES     215    215       PHOSPHORYLATION (BY PKA) (POTENTIAL).
FT   NON_TER     295    295
SQ   SEQUENCE   295 AA;  32254 MW;  20DB7DA0797A474C CRC64;
     MVFLSGNASD SSNCTHPPAP VNISKAILLG VILGGLIIFG VLGNILVILS VACHRHLHSV
     THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN IWAAVDVLCC TASIMGLCII
     SIDRYIGVSY PLRYPTIVTQ KRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQITE
     EPGYVLFSAL GSFYVPLTII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN
     APVGGTGVSS AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIG
//