ID   A1AA_HUMAN     STANDARD;      PRT;   466 AA.
AC   P35348;
DT   01-JUN-1994 (Rel. 29, Created)
DT   01-NOV-1995 (Rel. 32, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha-1C
DE   adrenergic receptor).
GN   ADRA1A OR ADRA1C.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Prostate;
RX   MEDLINE=93384619; PubMed=8396931;
RA   Hirasawa A., Horie K., Tanaka T., Takagaki K., Murai M., Yano J.,
RA   Tsujimoto G.;
RT   "Cloning, functional expression and tissue distribution of human cDNA
RT   for the alpha 1C-adrenergic receptor.";
RL   Biochem. Biophys. Res. Commun. 195:902-909(1993).
RN   [2]
RP   SEQUENCE FROM N.A.
RA   Tseng-Crank J.C., Goetz A., Saussy D., Roberson K.M., Hazum S.,
RA   Haizlip J., Godinot N., Wisely B., Robertson C.N., Kost T.;
RL   Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Hippocampus, and Lymphocytes;
RX   MEDLINE=94239386; PubMed=8183249;
RA   Forray C., Bard J.A., Wetzel J.M., Chiu G., Shapiro E., Tang R.,
RA   Lepor H., Hartig P.R., Weinshank R.L., Branchek T.A.,
RA   Gluchowski C.;
RT   "The alpha 1-adrenergic receptor that mediates smooth muscle
RT   contraction in human prostate has the pharmacological properties of
RT   the cloned human alpha 1c subtype.";
RL   Mol. Pharmacol. 45:703-708(1994).
RN   [4]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=95114877; PubMed=7815325;
RA   Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H.,
RA   Worman N.P., Campbell S., Fidock M.D., Furness L.M.,
RA   Parry-Smith D.J., Peter B., Bailey D.S.;
RT   "Cloning and pharmacological characterization of human alpha-1
RT   adrenergic receptors: sequence corrections and direct comparison with
RT   other species homologues.";
RL   J. Pharmacol. Exp. Ther. 272:134-142(1995).
RN   [5]
RP   SEQUENCE FROM N.A.
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: THIS ALPHA-ADRENERGIC RECEPTOR MEDIATES ITS ACTION BY
CC       ASSOCIATION WITH G PROTEINS THAT ACTIVATE A PHOSPHATIDYLINOSITOL-
CC       CALCIUM SECOND MESSENGER SYSTEM. ITS EFFECT IS MEDIATED BY G(Q)
CC       AND G(11) PROTEINS.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: HEART, BRAIN, LIVER AND PROSTATE, BUT NOT IN
CC       KIDNEY, LUNG, ADRENAL, AORTA AND PITUITARY.
CC   -!- PTM: CARBOXYL-TERMINAL SER OR THR RESIDUES MAY BE PHOSPHORYLATED
CC       (BY SIMILARITY).
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
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DR   EMBL; D25235; BAA04960.1; -.
DR   EMBL; U02569; AAA93114.1; -.
DR   EMBL; U03866; AAB60353.1; -.
DR   EMBL; L31774; AAB59486.1; -.
DR   EMBL; AB065703; BAC05926.1; -.
DR   Genew; HGNC:277; ADRA1A.
DR   MIM; 104221; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004937; F:alpha1-adrenergic receptor activity; TAS.
DR   GO; GO:0006915; P:apoptosis; TAS.
DR   GO; GO:0007267; P:cell-cell signaling; TAS.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; TAS.
DR   GO; GO:0007243; P:protein kinase cascade; TAS.
DR   GO; GO:0007165; P:signal transduction; TAS.
DR   GO; GO:0006939; P:smooth muscle contraction; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Multigene family; Phosphorylation; Lipoprotein; Palmitate.
FT   DOMAIN        1     27       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     28     51       1 (POTENTIAL).
FT   DOMAIN       52     64       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     65     88       2 (POTENTIAL).
FT   DOMAIN       89     99       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    100    122       3 (POTENTIAL).
FT   DOMAIN      123    143       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    144    167       4 (POTENTIAL).
FT   DOMAIN      168    181       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    182    205       5 (POTENTIAL).
FT   DOMAIN      206    273       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    274    297       6 (POTENTIAL).
FT   DOMAIN      298    305       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    306    329       7 (POTENTIAL).
FT   DOMAIN      330    466       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      7      7       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     13     13       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     22     22       N-LINKED (GLCNAC...) (POTENTIAL).
FT   MOD_RES     215    215       PHOSPHORYLATION (BY PKA) (POTENTIAL).
FT   DISULFID     99    176       BY SIMILARITY.
FT   LIPID       345    345       PALMITATE (POTENTIAL).
FT   CONFLICT     43     43       G -> C (IN REF. 2).
FT   CONFLICT    129    129       S -> T (IN REF. 2).
FT   CONFLICT    347    347       C -> R (IN REF. 1 AND 4).
FT   CONFLICT    359    359       T -> P (IN REF. 2).
FT   CONFLICT    431    431       Q -> E (IN REF. 1).
FT   CONFLICT    442    442       S -> C (IN REF. 2).
SQ   SEQUENCE   466 AA;  51486 MW;  1A50487531DECDF0 CRC64;
     MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV
     THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII
     SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE
     EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN
     APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD
     FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL
     HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT
     TARVRSKSFL QVCCCVGPST PSLDKNHQVP TIKVHTISLS ENGEEV
//