ID   B1AR_CANFA     STANDARD;      PRT;   473 AA.
AC   P79148;
DT   01-NOV-1997 (Rel. 35, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Beta-1 adrenergic receptor.
GN   ADRB1.
OS   Canis familiaris (Dog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=97364078; PubMed=9220370;
RA   Huang R.-R.C., Rapoport D., Schaeffer M.-T., Cascieri M.A.,
RA   Fong T.M.;
RT   "Molecular cloning of the dog beta 1 and beta 2 adrenergic
RT   receptors.";
RL   J. Recept. Signal Transduct. Res. 17:599-607(1997).
CC   -!- FUNCTION: BETA-ADRENERGIC RECEPTORS MEDIATE THE CATECHOLAMINE-
CC       INDUCED ACTIVATION OF ADENYLATE CYCLASE THROUGH THE ACTION OF G
CC       PROTEINS. THIS RECEPTOR BINDS EPINEPHRINE AND NOREPINEPHRINE WITH
CC       APPROXIMATIVELY EQUAL AFFINITY.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- PTM: HOMOLOGOUS DESENSITIZATION OF THE RECEPTOR IS MEDIATED BY ITS
CC       PHOSPHORYLATION BY BETA-ADRENERGIC RECEPTOR KINASE (BY
CC       SIMILARITY).
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; U73207; AAB93648.1; -.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Multigene family; Phosphorylation; Lipoprotein; Palmitate.
FT   DOMAIN        1     59       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     60     83       1 (POTENTIAL).
FT   DOMAIN       84     96       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     97    120       2 (POTENTIAL).
FT   DOMAIN      121    131       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    132    155       3 (POTENTIAL).
FT   DOMAIN      156    175       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    176    199       4 (POTENTIAL).
FT   DOMAIN      200    221       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    222    245       5 (POTENTIAL).
FT   DOMAIN      246    322       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    323    346       6 (POTENTIAL).
FT   DOMAIN      347    353       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    354    377       7 (POTENTIAL).
FT   DOMAIN      378    473       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     15     15       N-LINKED (GLCNAC...) (PROBABLE).
FT   DISULFID    131    209       BY SIMILARITY.
FT   MOD_RES     309    309       PHOSPHORYLATION (BY PKA) (POTENTIAL).
FT   LIPID       389    389       PALMITATE (BY SIMILARITY).
SQ   SEQUENCE   473 AA;  50060 MW;  361357F7DF9DBD7E CRC64;
     MGAGALALGA SEPCNLSSAA PLPDGAATAA RLLVPASPSA SPLAPTSEGP APLSQQWTAG
     IGLLMALIVL LIVAGNVLVI AAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVM
     RGRWEYGSFL CELWTSVDVL CVTASIETLC VIALDRYLAI TAPFRYQSLL TRARARALVC
     TVWAISALVS FLPILMHWWR AGGDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM
     AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPAPPPAPA PAPPPAPGSP RPAAAAPLAN
     GRVGRRRPSR LVALREQKAL KTLGIIMGVF TLCWLPFFLA NVVKAFHRDL VPDRLFVFFN
     WLGYANSAFN PIIYCRSPDF RRAFQRLLCC ARRAARGSHG AAGDPPRARP PPSPGAASDD
     DDDDEDDAGA GAGAAPPARL LEPWAGCNGG AAADSDSSLD GAGSPAGASE SRV
//