ID   B1AR_HUMAN     STANDARD;      PRT;   477 AA.
AC   P08588; Q9UKG7; Q9UKG8;
DT   01-AUG-1988 (Rel. 08, Created)
DT   01-AUG-1988 (Rel. 08, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Beta-1 adrenergic receptor.
GN   ADRB1 OR ADRB1R OR B1AR.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Placenta;
RX   MEDLINE=88068509; PubMed=2825170;
RA   Frielle T., Collins S., Daniel K.W., Caron M.G., Lefkowitz R.J.,
RA   Kobilka B.K.;
RT   "Cloning of the cDNA for the human beta 1-adrenergic receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:7920-7924(1987).
RN   [2]
RP   VARIANT ARG-389.
RX   MEDLINE=99230291; PubMed=10212248;
RA   Mason D.A., Moore J.D., Green S.A., Liggett S.B.;
RT   "A gain-of-function polymorphism in a G-protein coupling domain of the
RT   human beta1-adrenergic receptor.";
RL   J. Biol. Chem. 274:12670-12674(1999).
RN   [3]
RP   VARIANTS GLY-49 AND ARG-389.
RX   MEDLINE=99407229; PubMed=10477438;
RA   Moore J.D., Mason D.A., Green S.A., Hsu J., Liggett S.B.;
RT   "Racial differences in the frequencies of cardiac beta(1)-adrenergic
RT   receptor polymorphisms: analysis of c145A>G and c1165G>C.";
RL   Hum. Mutat. 14:271-271(1999).
RN   [4]
RP   VARIANT GLY-49.
RX   MEDLINE=20507547; PubMed=11052857;
RA   Borjesson M., Magnusson Y., Hjalmarson A., Andersson B.;
RT   "A novel polymorphism in the gene coding for the beta(1)-adrenergic
RT   receptor associated with survival in patients with heart failure.";
RL   Eur. Heart J. 21:1853-1858(2000).
RN   [5]
RP   VARIANT GLY-49.
RX   MEDLINE=21881226; PubMed=11854867;
RA   Ranade K., Jorgenson E., Sheu W.H.-H., Pei D., Hsiung C.A.,
RA   Chiang F.-T., Chen Y.-D.I., Pratt R., Olshen R.A., Curb D., Cox D.R.,
RA   Botstein D., Risch N.;
RT   "A polymorphism in the beta1 adrenergic receptor is associated with
RT   resting heart rate.";
RL   Am. J. Hum. Genet. 70:935-942(2002).
CC   -!- FUNCTION: BETA-ADRENERGIC RECEPTORS MEDIATE THE CATECHOLAMINE-
CC       INDUCED ACTIVATION OF ADENYLATE CYCLASE THROUGH THE ACTION OF G
CC       PROTEINS. THIS RECEPTOR BINDS EPINEPHRINE AND NOREPINEPHRINE WITH
CC       APPROXIMATIVELY EQUAL AFFINITY.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- PTM: HOMOLOGOUS DESENSITIZATION OF THE RECEPTOR IS MEDIATED BY ITS
CC       PHOSPHORYLATION BY BETA-ADRENERGIC RECEPTOR KINASE.
CC   -!- POLYMORPHISM: The variant Ser-49 is associated with high mean
CC       resting heart rate.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; J03019; AAA51667.1; -.
DR   EMBL; AF169006; AAD53696.1; -.
DR   EMBL; AF169007; AAD53697.1; -.
DR   PIR; A39911; A39911.
DR   Genew; HGNC:285; ADRB1.
DR   MIM; 109630; -.
DR   MIM; 607276; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004940; F:beta1-adrenergic receptor activity; TAS.
DR   GO; GO:0007190; P:adenylate cyclase activation; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Multigene family; Phosphorylation; Lipoprotein; Palmitate;
KW   Polymorphism.
FT   DOMAIN        1     59       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     60     83       1 (POTENTIAL).
FT   DOMAIN       84     96       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     97    120       2 (POTENTIAL).
FT   DOMAIN      121    131       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    132    155       3 (POTENTIAL).
FT   DOMAIN      156    175       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    176    199       4 (POTENTIAL).
FT   DOMAIN      200    221       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    222    245       5 (POTENTIAL).
FT   DOMAIN      246    325       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    326    349       6 (POTENTIAL).
FT   DOMAIN      350    356       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    357    380       7 (POTENTIAL).
FT   DOMAIN      381    477       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     15     15       N-LINKED (GLCNAC...) (PROBABLE).
FT   DISULFID    131    209       BY SIMILARITY.
FT   MOD_RES     312    312       PHOSPHORYLATION (BY PKA) (POTENTIAL).
FT   MOD_RES     412    412       PHOSPHORYLATION (BY PKA) (POTENTIAL).
FT   LIPID       392    392       PALMITATE (BY SIMILARITY).
FT   VARIANT      49     49       S -> G (IN dbSNP:1801252).
FT                                /FTId=VAR_009879.
FT   VARIANT     389    389       G -> R (ENHANCED BINDING TO G PROTEINS;
FT                                dbSNP:1801253).
FT                                /FTId=VAR_009880.
SQ   SEQUENCE   477 AA;  51223 MW;  1D15E6390B5364B8 CRC64;
     MGAGVLVLGA SEPGNLSSAA PLPDGAATAA RLLVPASPPA SLLPPASESP EPLSQQWTAG
     MGLLMALIVL LIVAGNVLVI VAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVV
     WGRWEYGSFF CELWTSVDVL CVTASIETLC VIALDRYLAI TSPFRYQSLL TRARARGLVC
     TVWAISALVS FLPILMHWWR AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM
     AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPSPSPSPV PAPAPPPGPP RPAAAAATAP
     LANGRAGKRR PSRLVALREQ KALKTLGIIM GVFTLCWLPF FLANVVKAFH RELVPDRLFV
     FFNWLGYANS AFNPIIYCRS PDFRKAFQGL LCCARRAARR RHATHGDRPR ASGCLARPGP
     PPSPGAASDD DDDDVVGATP PARLLEPWAG CNGGAAADSD SSLDEPCRPG FASESKV
//