ID   ADMR_HUMAN     STANDARD;      PRT;   404 AA.
AC   O15218;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Adrenomedullin receptor (AM-R).
GN   ADMR.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=98042541; PubMed=9367907;
RA   Haenze J., Dittrich K., Dotsch J., Rascher W.;
RT   "Molecular cloning of a novel human receptor gene with homology to the
RT   rat adrenomedullin receptor and high expression in heart and immune
RT   system.";
RL   Biochem. Biophys. Res. Commun. 240:183-188(1997).
CC   -!- FUNCTION: RECEPTOR FOR ADRENOMEDULLIN. THE ACTIVITY OF THIS
CC       RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE ADENYLATE
CC       CYCLASE (BY SIMILARITY).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: HIGHLY EXPRESSED IN HEART, SKELETAL MUSCLE,
CC       IMMUNE SYSTEM, ADRENAL GLAND AND LIVER.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC       HIGHEST RESEMBLANCE WITH THE RDC1 ORPHAN RECEPTOR.
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DR   EMBL; Y13583; CAA73910.1; -.
DR   Genew; HGNC:13708; ADMR.
DR   MIM; 605307; -.
DR   GO; GO:0016021; C:integral to membrane; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein.
FT   DOMAIN        1     57       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     58     79       1 (POTENTIAL).
FT   DOMAIN       80     90       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     91    113       2 (POTENTIAL).
FT   DOMAIN      114    127       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    128    149       3 (POTENTIAL).
FT   DOMAIN      150    170       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    171    193       4 (POTENTIAL).
FT   DOMAIN      194    217       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    218    239       5 (POTENTIAL).
FT   DOMAIN      240    258       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    259    280       6 (POTENTIAL).
FT   DOMAIN      281    299       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    300    320       7 (POTENTIAL).
FT   DOMAIN      321    404       CYTOPLASMIC (POTENTIAL).
FT   DISULFID    126    202       BY SIMILARITY.
FT   CARBOHYD     28     28       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     37     37       N-LINKED (GLCNAC...) (POTENTIAL).
SQ   SEQUENCE   404 AA;  45323 MW;  EF187ECFDF2DC6C1 CRC64;
     MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS TKRVVLFALY
     LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL GIVLSLPVWM LEVTLDYTWL
     WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD RYVTLTSASP SWQRYQHRVR RAMCAGIWVL
     SAIIPLPEVV HIQLVEGPEP MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL
     TACRLRQPGQ PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF
     FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA SSSSCSTQHS
     IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP LTPS
//