ID   APJ_HUMAN      STANDARD;      PRT;   380 AA.
AC   P35414;
DT   01-JUN-1994 (Rel. 29, Created)
DT   01-JUN-1994 (Rel. 29, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Apelin receptor (G protein-coupled receptor APJ) (Angiotensin
DE   receptor-like 1) (HG11).
GN   AGTRL1 OR APJ.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=94124031; PubMed=8294032;
RA   O'Dowd B.F., Heiber M., Chan A., Heng H.H.Q., Tsui L.-C.,
RA   Kennedy J.L., Shi X., Petronis A., George S.R., Nguyen T.;
RT   "A human gene that shows identity with the gene encoding the
RT   angiotensin receptor is located on chromosome 11.";
RL   Gene 136:355-360(1993).
RN   [2]
RP   SEQUENCE FROM N.A.
RA   Eggerickx D., Schurmans S., Vassart G., Parmentier M.;
RT   "Molecular cloning and tissue distribution of a human orphan receptor
RT   belonging to the G protein coupled receptors family.";
RL   Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for apelin coupled to G proteins that inhibit
CC       adenylate cyclase activity. Alternative coreceptor with CD4 for
CC       HIV-1 infection, maybe involved in the development of AIDS
CC       dementia.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: Widely expressed in the brain, in glial cells,
CC       astrocytes and neuronal subpopulations, as well as in the spleen,
CC       thymus, ovary, small intestine and colon.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; U03642; AAA18954.1; -.
DR   EMBL; X89271; CAA61546.1; -.
DR   Genew; HGNC:339; AGTRL1.
DR   MIM; 600052; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004872; F:receptor activity; TAS.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein.
FT   DOMAIN        1     26       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     27     51       1 (POTENTIAL).
FT   DOMAIN       52     66       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     67     91       2 (POTENTIAL).
FT   DOMAIN       92    100       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    101    125       3 (POTENTIAL).
FT   DOMAIN      126    144       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    145    166       4 (POTENTIAL).
FT   DOMAIN      167    200       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    201    221       5 (POTENTIAL).
FT   DOMAIN      222    244       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    245    271       6 (POTENTIAL).
FT   DOMAIN      272    284       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    285    308       7 (POTENTIAL).
FT   DOMAIN      309    380       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     15     15       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    175    175       N-LINKED (GLCNAC...) (POTENTIAL).
SQ   SEQUENCE   380 AA;  42660 MW;  78DB18BEA6D2B2E4 CRC64;
     MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK
     RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL
     TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ
     CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL
     RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV
     NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK
     GGEQMHEKSI PYSQETLVVD
//