ID   APJ_RAT        STANDARD;      PRT;   377 AA.
AC   Q9JHG3; Q9ESK2;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Apelin receptor (G protein-coupled receptor APJ) (Angiotensin
DE   receptor-like 1) (B78) (GPCR34).
GN   AGTRL1 OR APJ.
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain;
RX   MEDLINE=20347212; PubMed=10777510;
RA   Hosoya M., Kawamata Y., Fukusumi S., Fujii R., Habata Y., Hinuma S.,
RA   Kitada C., Honda S., Kurokawa T., Onda H., Nishimura O., Fujino M.;
RT   "Molecular and functional characteristics of APJ: tissue distribution
RT   of mRNA and interaction with the endogenous ligand apelin.";
RL   J. Biol. Chem. 275:21061-21067(2000).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   STRAIN=Sprague-Dawley; TISSUE=Pituitary;
RX   MEDLINE=20461761; PubMed=11004481;
RA   O'Carroll A.-M., Selby T.L., Palkovits M., Lolait S.J.;
RT   "Distribution of mRNA encoding B78/apj, the rat homologue of the human
RT   APJ receptor, and its endogenous ligand apelin in brain and peripheral
RT   tissues.";
RL   Biochim. Biophys. Acta 1492:72-80(2000).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain;
RX   MEDLINE=21066694; PubMed=11146423;
RA   De Mota N., Lenkei Z., Llorens-Cortes C.;
RT   "Cloning, pharmacological characterization and brain distribution of
RT   the rat apelin receptor.";
RL   Neuroendocrinology 72:400-407(2000).
RN   [4]
RP   SEQUENCE OF 75-300 FROM N.A.
RC   STRAIN=Sprague-Dawley;
RA   Carroll S.L., Miller M.L., Benedict-Hamilton H.M.;
RT   "Identification and characterization of novel G-protein coupled
RT   receptors expressed in regenerating peripheral nerve.";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   CHARACTERIZATION.
RX   MEDLINE=21259968; PubMed=11359874;
RA   Reaux A., De Mota N., Skultetyova I., Lenkei Z., El Messari S.,
RA   Gallatz K., Corvol P., Palkovits M., Llorens-Cortes C.;
RT   "Physiological role of a novel neuropeptide, apelin, and its receptor
RT   in the rat brain.";
RL   J. Neurochem. 77:1085-1096(2001).
CC   -!- FUNCTION: Receptor for apelin coupled to G proteins that inhibit
CC       adenylate cyclase activity.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: Widely expressed. Highest expression in the
CC       lung, lower in the heart, placenta, ovary, skeletal muscle,
CC       mammary gland, kidney and several structures in the brain as the
CC       hypothalamus (supraoptic and periventricular nuclei), pituitary,
CC       olfactory bulb and pineal gland.
CC   -!- DEVELOPMENTAL STAGE: Higher expression in neonates than in adult
CC       rats.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
DR   EMBL; AB033170; BAA95002.1; -.
DR   EMBL; AF184883; AAF80860.1; -.
DR   EMBL; AF090346; AAG24468.1; -.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Glycoprotein; Transmembrane.
FT   DOMAIN        1     30       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     31     53       1 (POTENTIAL).
FT   DOMAIN       54     64       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     65     87       2 (POTENTIAL).
FT   DOMAIN       88    106       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    107    129       3 (POTENTIAL).
FT   DOMAIN      130    141       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    142    164       4 (POTENTIAL).
FT   DOMAIN      165    200       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    201    223       5 (POTENTIAL).
FT   DOMAIN      224    242       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    243    265       6 (POTENTIAL).
FT   DOMAIN      266    284       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    285    307       7 (POTENTIAL).
FT   DOMAIN      308    377       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     13     13       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    173    173       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CONFLICT    117    117       C -> W (IN REF. 4).
FT   CONFLICT    187    187       A -> G (IN REF. 4).
FT   CONFLICT    198    198       G -> R (IN REF. 4).
FT   CONFLICT    251    251       L -> P (IN REF. 4).
SQ   SEQUENCE   377 AA;  42349 MW;  C43F81EBC3855BB2 CRC64;
     MEDDGYNYYG ADNQSECDYA DWTPSGALIP AIYILVFLLG TTGNGLVLWT VFWSSREKRR
     SADIFIASLA VADLTFVVTL PLWATYTYRE FDWPFGTFSC KLSSYLIFVN MYASVFCLTG
     LSFDRYLAIV RPVANARLRL RVSGAVATAV LWVLAALLAV PVMVFRSTDI PENSTKTQCY
     MDYSMVATSN SEWAWEVGLG VSSTAVGFVV PFIIMLTCYF FIAQTIAGHF RKERIEGLRK
     RRRLLSIIVV LVVTFALCWM PYHLVKTLYM LGNLLHWPCD FDSFLMNVFP YCTCISYVNS
     CLNPFLYAFF DPRFRRACTS MLCCDQSGCK GSPHSSSAEK SASYSSGHSQ GPGPNMCKGG
     EPMHEKSIPY SQETLVD
//