ID   BRB1_HUMAN     STANDARD;      PRT;   353 AA.
AC   P46663; Q8N0Y8;
DT   01-NOV-1995 (Rel. 32, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   B1 bradykinin receptor (BK-1 receptor) (B1R).
GN   BDKRB1 OR BRADYB1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96244567; PubMed=8651911;
RA   Yang X., Polgar P.;
RT   "Genomic structure of the human bradykinin B1 receptor gene and
RT   preliminary characterization of its regulatory regions.";
RL   Biochem. Biophys. Res. Commun. 222:718-725(1996).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=94342346; PubMed=8063797;
RA   Menke J.G., Borkowski J.A., Bierilo K.K., Macneil T., Derrick A.W.,
RA   Schneck K.A., Ransom R.W., Strader C.D., Linemeyer D.L., Hess J.F.;
RT   "Expression cloning of a human B1 bradykinin receptor.";
RL   J. Biol. Chem. 269:21583-21586(1994).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96299633; PubMed=8660997;
RA   Bachvarov D.R., Hess J.F., Menke J.G., Larrivee J.F., Marceau F.;
RT   "Structure and genomic organization of the human B1 receptor gene for
RT   kinins (BDKRB1).";
RL   Genomics 33:374-381(1996).
RN   [4]
RP   SEQUENCE FROM N.A.
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Skin;
RX   MEDLINE=22388257; PubMed=12477932;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length
RT   human and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: THIS IS A RECEPTOR FOR BRADYKININ. COULD BE A FACTOR IN
CC       CHRONIC PAIN AND INFLAMMATION.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; U22346; AAC50594.1; -.
DR   EMBL; U12512; AAA21346.1; -.
DR   EMBL; U48231; AAB60693.1; -.
DR   EMBL; AB065896; BAC06112.1; -.
DR   EMBL; BC034705; AAH34705.1; -.
DR   HSSP; P02699; 1F88.
DR   Genew; HGNC:1029; BDKRB1.
DR   MIM; 600337; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; TAS.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004947; F:bradykinin receptor activity; TAS.
DR   GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Lipoprotein; Palmitate; Polymorphism.
FT   DOMAIN        1     40       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     41     64       1 (POTENTIAL).
FT   DOMAIN       65     73       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     74     98       2 (POTENTIAL).
FT   DOMAIN       99    111       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    112    133       3 (POTENTIAL).
FT   DOMAIN      134    155       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    156    178       4 (POTENTIAL).
FT   DOMAIN      179    199       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    200    226       5 (POTENTIAL).
FT   DOMAIN      227    247       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    248    272       6 (POTENTIAL).
FT   DOMAIN      273    291       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    292    314       7 (POTENTIAL).
FT   DOMAIN      316    353       CYTOPLASMIC (POTENTIAL).
FT   DISULFID    110    189       BY SIMILARITY.
FT   LIPID       330    330       PALMITATE (POTENTIAL).
FT   CARBOHYD     14     14       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     22     22       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    185    185       N-LINKED (GLCNAC...) (POTENTIAL).
FT   VARIANT     250    250       A -> V (IN dbSNP:2229459).
FT                                /FTId=VAR_014359.
FT   CONFLICT    146    146       G -> R (IN REF. 4 AND 5).
FT   CONFLICT    240    243       VRGP -> CGGR (IN REF. 4 AND 5).
FT   CONFLICT    246    246       S -> R (IN REF. 1).
FT   CONFLICT    259    259       F -> S (IN REF. 1).
SQ   SEQUENCE   353 AA;  40431 MW;  6C185E50C795636D CRC64;
     MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF GLLGNLFVLL
     VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ FNWPFGALLC RVINGVIKAN
     LFISIFLVVA ISQDRYRVLV HPMASGRQQR RRQARVTCVL IWVVGGLLSI PTFLLRSIQA
     VPDLNITACI LLLPHEAWHF ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRV
     RGPKDSKTTA LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF
     AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF WRN
//