ID   CB1R_HUMAN     STANDARD;      PRT;   472 AA.
AC   P21554; Q13949; Q9UNN0;
DT   01-MAY-1991 (Rel. 18, Created)
DT   01-MAY-1991 (Rel. 18, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   Cannabinoid receptor 1 (CB1) (CB-R) (CANN6).
GN   CNR1 OR CNR.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORM LONG).
RC   TISSUE=Brain stem;
RX   MEDLINE=92028798; PubMed=1718258;
RA   Gerard C., Mollereau C., Vassart G., Parmentier M.;
RT   "Molecular cloning of a human cannabinoid receptor which is also
RT   expressed in testis.";
RL   Biochem. J. 279:129-134(1991).
RN   [2]
RP   SEQUENCE FROM N.A. (ISOFORM LONG).
RC   TISSUE=Brain stem;
RX   MEDLINE=91088303; PubMed=2263478;
RA   Gerard C., Mollereau C., Vassart G., Parmentier M.;
RT   "Nucleotide sequence of a human cannabinoid receptor cDNA.";
RL   Nucleic Acids Res. 18:7142-7142(1990).
RN   [3]
RP   SEQUENCE FROM N.A. (ISOFORMS LONG AND SHORT).
RC   TISSUE=Lung;
RX   MEDLINE=95181329; PubMed=7876112;
RA   Shire D., Carillon C., Khaghad M., Calendra B., Rinaldi-Carmona M.,
RA   le Fur G., Caput D., Ferrara P.;
RT   "An amino-terminal variant of the central cannabinoid receptor
RT   resulting from alternative splicing.";
RL   J. Biol. Chem. 270:3726-3731(1995).
RN   [4]
RP   SEQUENCE FROM N.A. (ISOFORM LONG).
RC   TISSUE=Hippocampus;
RA   Kathmann M., Schlicker E.;
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   SEQUENCE FROM N.A. (ISOFORM LONG).
RA   Bonner T.I.;
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   SEQUENCE FROM N.A.
RA   Williams S.;
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in cannabinoid-induced CNS effects. Acts by
CC       inhibiting adenylate cyclase. Could be a receptor for anandamide.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=P21554-1; Sequence=Displayed;
CC       Name=Short; Synonyms=CB1A;
CC         IsoId=P21554-2; Sequence=VSP_001868;
CC   -!- TISSUE SPECIFICITY: FOUND IN ALL PERIPHERAL ORGANS TESTED: HEART,
CC       COLON, STOMACH, LIVER, PANCREAS, PLACENTA, LUNG, KIDNEY, BILE
CC       DUCT, SPLEEN, ADRENAL GLAND, MUSCLE, BRAIN, AND TESTIS; AND
CC       THROUGHOUT THE CENTRAL NERVOUS SYSTEM.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; X54937; CAA38699.1; -.
DR   EMBL; X81120; CAA57018.1; -.
DR   EMBL; X81121; CAA57019.1; -.
DR   EMBL; AF107262; AAD34320.1; -.
DR   EMBL; U73304; AAB18200.1; -.
DR   EMBL; AL136096; CAB96726.1; -.
DR   PIR; S13668; S13668.
DR   PIR; S17595; S17595.
DR   Genew; HGNC:2159; CNR1.
DR   MIM; 114610; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004949; F:cannabinoid receptor activity; TAS.
DR   GO; GO:0007610; P:behavior; TAS.
DR   GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Alternative splicing.
FT   DOMAIN        1    116       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    117    142       1 (POTENTIAL).
FT   DOMAIN      143    154       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    155    175       2 (POTENTIAL).
FT   DOMAIN      176    187       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    188    212       3 (POTENTIAL).
FT   DOMAIN      213    232       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    233    255       4 (POTENTIAL).
FT   DOMAIN      256    273       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    274    299       5 (POTENTIAL).
FT   DOMAIN      300    344       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    345    365       6 (POTENTIAL).
FT   DOMAIN      366    377       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    378    399       7 (POTENTIAL).
FT   DOMAIN      400    472       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     77     77       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     83     83       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    112    112       N-LINKED (GLCNAC...) (POTENTIAL).
FT   VARSPLIC      1     89       MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKL
FT                                GYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFY
FT                                NKSLSSF -> MALQIPPSAPSPLTSCTWAQMTFSTKTS
FT                                (in isoform Short).
FT                                /FTId=VSP_001868.
FT   CONFLICT    200    200       F -> L (IN REF. 4).
FT   CONFLICT    216    216       I -> V (IN REF. 4).
FT   CONFLICT    246    246       V -> A (IN REF. 4).
SQ   SEQUENCE   472 AA;  52857 MW;  1D2E49061D12ABF2 CRC64;
     MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE
     KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE NFMDIECFMV LNPSQQLAIA
     VLSLTLGTFT VLENLLVLCV ILHSRSLRCR PSYHFIGSLA VADLLGSVIF VYSFIDFHVF
     HRKDSRNVFL FKLGGVTASF TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAVVAFCLM
     WTIAIVIAVL PLLGWNCEKL QSVCSDIFPH IDETYLMFWI GVTSVLLLFI VYAYMYILWK
     AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV VLIICWGPLL
     AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR SKDLRHAFRS MFPSCEGTAQ
     PLDNSMGDSD CLHKHANNAA SVHRAAESCI KSTVKIAKVT MSVSTDTSAE AL
//