ID   CB1R_MOUSE     STANDARD;      PRT;   473 AA.
AC   P47746;
DT   01-FEB-1996 (Rel. 33, Created)
DT   01-FEB-1996 (Rel. 33, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   Cannabinoid receptor 1 (CB1) (CB-R) (Brain-type cannabinoid receptor).
GN   CNR1.
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=C57BL/6; TISSUE=Brain;
RX   MEDLINE=96272305; PubMed=8777318;
RA   Chakrabarti A., Onaivi E.S., Chaudhuri G.;
RT   "Cloning and sequencing of a cDNA encoding the mouse brain-type
RT   cannabinoid receptor protein.";
RL   DNA Seq. 5:385-388(1995).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   STRAIN=129;
RA   Bonner T.I.;
RL   Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96429553; PubMed=8832654;
RA   Ho B.Y., Zhao J.;
RT   "Determination of the cannabinoid receptors in mouse x rat hybridoma
RT   NG108-15 cells and rat GH4C1 cells.";
RL   Neurosci. Lett. 212:123-126(1996).
RN   [4]
RP   SEQUENCE FROM N.A.
RA   Yuan Z.-Q., Li L., Qiu B.-S., Song D.-K.;
RT   "cDNA cloning and expression analysis of mouse cannabinoid receptor
RT   (CB1) gene.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   SEQUENCE FROM N.A.
RC   STRAIN=129/Sv;
RX   MEDLINE=99105999; PubMed=9888857;
RA   Ledent C., Valverde O., Cossu G., Petitet F., Aubert J.F., Beslot F.,
RA   Boehme G.A., Imperato A., Pedrazzini T., Roques B.P., Vassart G.,
RA   Fratta W., Parmentier M.;
RT   "Unresponsiveness to cannabinoids and reduced addictive effects of
RT   opiates in CB1 receptor knockout mice.";
RL   Science 283:401-404(1999).
CC   -!- FUNCTION: Involved in cannabinoid-induced CNS effects. Acts by
CC       inhibiting adenylate cyclase. Could be a receptor for anandamide.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; U17985; AAA57202.1; -.
DR   EMBL; U22948; AAA64413.1; -.
DR   EMBL; U40709; AAA91176.1; -.
DR   EMBL; AF153345; AAD34624.1; -.
DR   EMBL; Y18374; CAB42647.1; -.
DR   MGD; MGI:104615; Cnr1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein.
FT   DOMAIN        1    117       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    118    143       1 (POTENTIAL).
FT   DOMAIN      144    155       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    156    176       2 (POTENTIAL).
FT   DOMAIN      177    188       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    189    213       3 (POTENTIAL).
FT   DOMAIN      214    233       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    234    256       4 (POTENTIAL).
FT   DOMAIN      257    274       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    275    300       5 (POTENTIAL).
FT   DOMAIN      301    345       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    346    366       6 (POTENTIAL).
FT   DOMAIN      367    378       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    379    400       7 (POTENTIAL).
FT   DOMAIN      401    473       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     78     78       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     84     84       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CONFLICT      9      9       A -> G (IN REF. 1).
FT   CONFLICT    115    115       S -> R (IN REF. 1).
FT   CONFLICT    211    211       T -> R (IN REF. 1).
SQ   SEQUENCE   473 AA;  52830 MW;  E504168191CB6429 CRC64;
     MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE
     KMTAGDNSPL VPAGDTTNIT EFYNKSLSSF KENEDNIQCG ENFMDMECFM ILNPSQQLAI
     AVLSLTLGTF TVLENLLVLC VILHSRSLRC RPSYHFIGSL AVADLLGSVI FVYSFVDFHV
     FHRKDSPNVF LFKLGGVTAS FTASVGSLFL TAIDRYISIH RPLAYKRIVT RPKAVVAFCL
     MWTIAIVIAV LPLLGWNCKK LQSVCSDIFP LIDETYLMFW IGVTSVLLLF IVYAYMYILW
     KAHSHAVRMI QRGTQKSIII HTSEDGKVQV TRPDQARMDI RLAKTLVLIL VVLIICWGPL
     LAIMVYDVFG KMNKLIKTVF AFCSMLCLLN STVNPIIYAL RSKDLRHAFR SMFPSCEGTA
     QPLDNSMGDS DCLHKHANNT ASMHRAAESC IKSTVKIAKV TMSVSTDTSA EAL
//