ID   CATE_CAVPO     STANDARD;      PRT;   391 AA.
AC   P25796;
DT   01-MAY-1992 (Rel. 22, Created)
DT   01-MAY-1992 (Rel. 22, Last sequence update)
DT   15-JUN-2002 (Rel. 41, Last annotation update)
DE   Cathepsin E precursor (EC 3.4.23.34).
GN   CTSE.
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Rodentia; Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   SEQUENCE FROM N.A., AND CHARACTERIZATION.
RX   MEDLINE=92355614; PubMed=1644829;
RA   Kageyama T., Ichinose M., Tsukada S., Miki K., Kurokawa K., Koiwai O.,
RA   Tanji M., Yakabe E., Athauda S.B., Takahashi K.;
RT   "Gastric procathepsin E and progastricsin from guinea pig.
RT   Purification, molecular cloning of cDNAs, and characterization of
RT   enzymatic properties, with special reference to procathepsin E.";
RL   J. Biol. Chem. 267:16450-16459(1992).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Gastric mucosa;
RX   MEDLINE=96073637; PubMed=8540321;
RA   Kageyama T., Ichinose M., Miki K., Moriyama A., Yonezawa S.,
RA   Tanji M., Athauda S.B., Takahashi K.;
RT   "Isolation, characterization, and structure of procathepsin E and
RT   cathepsin E from the gastric mucosa of guinea pig.";
RL   Adv. Exp. Med. Biol. 362:211-221(1995).
CC   -!- FUNCTION: DUE OT ITS INTRACELLULAR LOCATION AND DISTRIBUTION IN
CC       LYMPHOID ASSOCIATED TISSUE, IT MAY HAVE A ROLE IN IMMUNE FUNCTION.
CC   -!- CATALYTIC ACTIVITY: Similar to cathepsin D, but slightly broader
CC       specificity.
CC   -!- SUBUNIT: HOMODIMER; DISULFIDE-LINKED.
CC   -!- SIMILARITY: BELONGS TO PEPTIDASE FAMILY A1.
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DR   EMBL; M88653; AAA37052.1; -.
DR   EMBL; S80547; AAB35844.1; -.
DR   PIR; A43356; A43356.
DR   HSSP; P00794; 4CMS.
DR   MEROPS; A01.010; -.
DR   InterPro; IPR001461; AspproteaseA1.
DR   InterPro; IPR001969; Aspprotease_site.
DR   Pfam; PF00026; asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
KW   Hydrolase; Aspartyl protease; Glycoprotein; Zymogen; Signal.
FT   SIGNAL        1     18       POTENTIAL.
FT   PROPEP       19     53       ACTIVATION PEPTIDE (POTENTIAL).
FT   CHAIN        54    391       CATHEPSIN E.
FT   ACT_SITE     92     92       BY SIMILARITY.
FT   ACT_SITE    276    276       BY SIMILARITY.
FT   DISULFID     56     56       INTERCHAIN (PROBABLE).
FT   DISULFID    105    110       BY SIMILARITY.
FT   DISULFID    267    271       BY SIMILARITY.
FT   DISULFID    309    346       BY SIMILARITY.
FT   CARBOHYD     86     86       N-LINKED (GLCNAC...) (POTENTIAL).
SQ   SEQUENCE   391 AA;  42132 MW;  78D216BF8CFCDABD CRC64;
     MKTFLLLLLV LLELGQAPGA LHRVPLSRRE SLRKKLRAQG QLTELWKSQN LNMDQCSTIQ
     SANEPLINYL DMEYFGTISI GSPPQNFTVI FDTGSSNLWV PSVYCTSPAC QTHPVFHPSL
     SSTYREVGNS FSIQYGTGSL TGIIGADQVS VEGLTVVGQQ FGESVQEPGK TFVHAEFDGI
     LGLGYPSLAA GGVTPVFDNM MAQNLVALPM FSVYMSSNPG GSGSELTFGG YDPSHFSGSL
     NWVPVTKQAY WQIALDGIQV GDSVMFCSEG CQAIVDTGTS LITGPPGKIK QLQEALGATY
     VDEGYSVQCA NLNMMLDVTF IINGVPYTLN PTAYTLLDFV DGMQVCSTGF EGLEIQPPAG
     PLWILGDVFI RQFYAVFDRG NNRVGLAPAV P
//