ID   C3AR_HUMAN     STANDARD;      PRT;   482 AA.
AC   Q16581; O43771; Q92868;
DT   15-JUL-1998 (Rel. 36, Created)
DT   15-JUL-1998 (Rel. 36, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   C3a anaphylatoxin chemotactic receptor (C3a-R) (C3AR).
GN   C3AR1 OR C3R1 OR AZ3B OR HNFAG09.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96180983; PubMed=8605247;
RA   Roglic A., Prossnitz E.R., Cavanagh S.L., Pan Z., Zou A., Ye R.D.;
RT   "cDNA cloning of a novel G protein-coupled receptor with a large
RT   extracellular loop structure.";
RL   Biochim. Biophys. Acta 1305:39-43(1996).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96350520; PubMed=8765043;
RA   Crass T., Raffetseder U., Martin U., Grove M., Klos A., Koehl J.,
RA   Bautsch W.;
RT   "Expression cloning of the human C3a anaphylatoxin receptor (C3aR)
RT   from differentiated U-937 cells.";
RL   Eur. J. Immunol. 26:1944-1950(1996).
RN   [3]
RP   REVISIONS.
RA   Bautsch W.;
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96355342; PubMed=8702752;
RA   Ames R.S., Li Y., Sarau H.M., Nuthulaganti P., Foley J.J., Ellis C.,
RA   Zeng Z., Su K., Jurewicz A.J., Hertzberg R.P., Bergsma D.J.,
RA   Kumar C.;
RT   "Molecular cloning and characterization of the human anaphylatoxin
RT   C3a receptor.";
RL   J. Biol. Chem. 271:20231-20234(1996).
CC   -!- FUNCTION: RECEPTOR FOR THE CHEMOTACTIC AND INFLAMMATORY PEPTIDE
CC       ANAPHYLATOXIN C3A. THIS RECEPTOR STIMULATES CHEMOTAXIS, GRANULE
CC       ENZYME RELEASE AND SUPEROXIDE ANION PRODUCTION.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: WIDELY EXPRESSED IN SEVERAL DIFFERENTIATED
CC       HEMATOPOIETIC CELL LINES, IN THE LUNG, SPLEEN, OVARY, PLACENTA,
CC       SMALL INTESTINE, THROUGHOUT THE BRAIN, HEART, AND ENDOTHELIAL
CC       CELLS. MOSTLY EXPRESSED IN LYMPHOID TISSUES.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; U28488; AAC50374.1; -.
DR   EMBL; Z73157; CAA97504.1; -.
DR   EMBL; U62027; AAC50657.1; -.
DR   Genew; HGNC:1319; C3AR1.
DR   MIM; 605246; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004943; F:C3a anaphylatoxin receptor activity; TAS.
DR   GO; GO:0004876; F:complement component C3a receptor activity; TAS.
DR   GO; GO:0008015; P:circulation; TAS.
DR   GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS.
DR   GO; GO:0006954; P:inflammatory response; TAS.
DR   GO; GO:0007203; P:phosphatidylinositol-4,5-bisphosphate hydro...; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Chemotaxis.
FT   DOMAIN        1     23       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     24     46       1 (POTENTIAL).
FT   DOMAIN       47     57       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     58     80       2 (POTENTIAL).
FT   DOMAIN       81     96       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     97    118       3 (POTENTIAL).
FT   DOMAIN      119    139       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    140    160       4 (POTENTIAL).
FT   DOMAIN      161    340       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    341    360       5 (POTENTIAL).
FT   DOMAIN      361    377       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    378    400       6 (POTENTIAL).
FT   DOMAIN      401    417       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    418    438       7 (POTENTIAL).
FT   DOMAIN      439    482       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      9      9       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    194    194       N-LINKED (GLCNAC...) (POTENTIAL).
FT   DISULFID     95    172       BY SIMILARITY.
FT   CONFLICT    151    151       F -> C (IN REF. 4).
FT   CONFLICT    203    203       R -> P (IN REF. 3 AND 4).
SQ   SEQUENCE   482 AA;  53923 MW;  AAD60B9CEED9B203 CRC64;
     MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL KMQRTVNTIW
     FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS IIVLNMFASV FLLTAISLDR
     CLVVFKPIWC QNHRNVGMAC SICGCIWVVA FVMCIPVFVY REIFTTDNHN RCGYKFGLSS
     SLDYPDFYGD PLENRSLENI VQRPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD
     SLPRGSARLT SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA
     SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV IMIACYSFIV
     FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS LLTDPETPLG KTLMSWDHVC
     IALASANSCF NPFLYALLGK DFRKKARQSI QGILEAAFSE ELTRSTHCPS NNVISERNST
     TV
//