ID   C5AR_CAVPO     STANDARD;      PRT;   345 AA.
AC   O70129;
DT   30-MAY-2000 (Rel. 39, Created)
DT   30-MAY-2000 (Rel. 39, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   C5a anaphylatoxin chemotactic receptor (C5a-R).
GN   C5R1.
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Rodentia; Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=Hartley;
RX   MEDLINE=98236152; PubMed=9576615;
RA   Fukuoka Y., Ember J.A., Yasui A., Hugli T.E.;
RT   "Cloning and characterization of the guinea pig C5a anaphylatoxin
RT   receptor: interspecies diversity among the C5a receptors.";
RL   Int. Immunol. 10:275-283(1998).
CC   -!- FUNCTION: RECEPTOR FOR THE CHEMOTACTIC AND INFLAMMATORY PEPTIDE
CC       ANAPHYLATOXIN C5A. THIS RECEPTOR STIMULATES CHEMOTAXIS, GRANULE
CC       ENZYME RELEASE AND SUPEROXIDE ANION PRODUCTION (BY SIMILARITY).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- PTM: SULFATION PLAYS A CRITICAL ROLE IN THE ASSOCIATION OF C5AR
CC       WITH C5A, BUT NO SIGNIFICANT ROLE IN THE ABILITY OF THE RECEPTOR
CC       TO TRANSDUCE A SIGNAL AND MOBILIZE CALCIUM IN RESPONSE TO A SMALL
CC       PEPTIDE AGONIST (BY SIMILARITY).
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; U86103; AAC40074.1; -.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein; Sulfation;
KW   Chemotaxis.
FT   DOMAIN        1     32       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     33     55       1 (POTENTIAL).
FT   DOMAIN       56     66       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     67     89       2 (POTENTIAL).
FT   DOMAIN       90    105       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    106    127       3 (POTENTIAL).
FT   DOMAIN      128    148       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    149    169       4 (POTENTIAL).
FT   DOMAIN      170    195       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    196    221       5 (POTENTIAL).
FT   DOMAIN      222    237       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    238    260       6 (POTENTIAL).
FT   DOMAIN      261    277       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    278    298       7 (POTENTIAL).
FT   DOMAIN      299    345       CYTOPLASMIC (POTENTIAL).
FT   DISULFID    104    183       BY SIMILARITY.
FT   MOD_RES       7      7       SULFATION (BY SIMILARITY).
FT   MOD_RES       9      9       SULFATION (BY SIMILARITY).
FT   MOD_RES      11     11       SULFATION (BY SIMILARITY).
FT   CARBOHYD     12     12       N-LINKED (GLCNAC...) (POTENTIAL).
SQ   SEQUENCE   345 AA;  38592 MW;  BE40459F1450404A CRC64;
     MMVTVSYDYD YNSTFLPDGF VDNYVERLSF GDLVAVVIMV VVFLVGVPGN ALVVWVTACE
     ARRHINAIWF LNLAAADLLS CLALPILLVS TVHLNHWYFG DTACKVLPSL ILLNMYTSIL
     LLATISADRL LLVLSPIWCQ RFRGGCLAWT ACGLAWVLAL LLSSPSFLYR RTHNEHFSFK
     VYCVTDYGRD ISKERAVALV RLLVGFIVPL ITLTACYTFL LLRTWSRKAT RSAKTVKVVV
     AVVSSFFVFW LPYQVTGILL AWHSPNSATY RNTKALDAVC VAFAYINCCI NPIIYVVAGH
     GFQGRLLKSL PSVLRNVLTE ESLDKRHQSF ARSTVDTMPQ KSESV
//