ID   FML1_HUMAN     STANDARD;      PRT;   351 AA.
AC   P25090;
DT   01-MAY-1992 (Rel. 22, Created)
DT   01-JUL-1993 (Rel. 26, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   FMLP-related receptor I (FMLP-R-I) (Lipoxin A4 receptor) (LXA4
DE   receptor) (RFP) (HM63).
GN   FPRL1 OR FPRH1 OR FPR2 OR LXA4R.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=92307681; PubMed=1612600;
RA   Bao L., Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.;
RT   "Mapping of genes for the human C5a receptor (C5AR), human FMLP
RT   receptor (FPR), and two FMLP receptor homologue orphan receptors
RT   (FPRH1, FPRH2) to chromosome 19.";
RL   Genomics 13:437-440(1992).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Bone marrow;
RX   MEDLINE=92380523; PubMed=1511907;
RA   Perez H.D., Holmes R., Kelly E., McClary J., Andrews W.H.;
RT   "Cloning of a cDNA encoding a receptor related to the formyl peptide
RT   receptor of human neutrophils.";
RL   Gene 118:303-304(1992).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Granulocyte;
RX   MEDLINE=92246937; PubMed=1374236;
RA   Ye R.D., Cavanagh S.L., Quehenberger O., Prossnitz E.R.,
RA   Cochrane C.G.;
RT   "Isolation of a cDNA that encodes a novel granulocyte N-formyl
RT   peptide receptor.";
RL   Biochem. Biophys. Res. Commun. 184:582-589(1992).
RN   [4]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=92218423; PubMed=1373134;
RA   Murphy P.M., Ozcelik T., Kenney R.T., Tiffany H.L., McDermott D.,
RA   Francke U.;
RT   "A structural homologue of the N-formyl peptide receptor.
RT   Characterization and chromosome mapping of a peptide chemoattractant
RT   receptor family.";
RL   J. Biol. Chem. 267:7637-7643(1992).
RN   [5]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Monocytes;
RX   MEDLINE=94092629; PubMed=7505609;
RA   Nomura H., Nielsen B.W., Matsushima K.;
RT   "Molecular cloning of cDNAs encoding a LD78 receptor and putative
RT   leukocyte chemotactic peptide receptors.";
RL   Int. Immunol. 5:1239-1249(1993).
RN   [6]
RP   SEQUENCE FROM N.A.
RA   Maddox J.F., Hachicha M., Takano T., Petasis N.A., Fokin V.V.,
RA   Serhan C.N.;
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=98215774; PubMed=9547339;
RA   Gronert K., Gewirtz A., Madara J.L., Serhan C.N.;
RT   "Identification of a human enterocyte lipoxin A4 receptor that is
RT   regulated by interleukin (IL)-13 and interferon gamma and inhibits
RT   tumor necrosis factor alpha-induced IL-8 release.";
RL   J. Exp. Med. 187:1285-1294(1998).
RN   [8]
RP   SEQUENCE FROM N.A.
RA   Lamerdin J.E., McCready P.M., Skowronski E., Viswanathan V.,
RA   Burkhart-Schultz K., Gordon L., Dias J., Ramirez M., Stilwagen S.,
RA   Phan H., Velasco N., Do L., Regala W., Terry A., Brower A., Garnes J.,
RA   Danganan L., Erler A., Christensen M., Georgescu A., Avila J., Liu S.,
RA   Andreise T., Trankheim M., Attix C., Amico-Keller G., Coefield J.,
RA   Duarte S., Lucas S., Bruce R., Thomas P., Quan G., Kronmiller B.,
RA   Arellano A., Sanders C., Ow D., Nolan M., Trong S., Kobayashi A.,
RA   Olsen A.S., Carrano A.V.;
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   TISSUE SPECIFICITY.
RX   MEDLINE=97296322; PubMed=9151906;
RA   Takano T., Fiore S., Maddox J.F., Brady H.R., Petasis N.A.,
RA   Serhan C.N.;
RT   "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues
RT   are potent inhibitors of acute inflammation: evidence for
RT   anti-inflammatory receptors.";
RL   J. Exp. Med. 185:1693-1704(1997).
CC   -!- FUNCTION: LOW AFFINITY RECEPTOR TO N-FORMYL-METHIONYL PEPTIDES,
CC       WHICH ARE POWERFUL NEUTROPHILS CHEMOTACTIC FACTORS. BINDING OF
CC       FMLP TO THE RECEPTOR CAUSES ACTIVATION OF NEUTROPHILS. THIS
CC       RESPONSE IS MEDIATED VIA A G-PROTEIN THAT ACTIVATES A
CC       PHOSPHATIDYLINOSITOL-CALCIUM SECOND MESSENGER SYSTEM. THE
CC       ACTIVATION OF LXA4R COULD RESULT IN AN ANTI-INFLAMMATORY OUTCOME
CC       COUNTERACTING THE ACTIONS OF PROINFLAMMATORY SIGNALS SUCH AS LTB4
CC       (LEUKOTRIENE B4).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: EXPRESSED ABUNDANTLY IN THE LUNG AND
CC       NEUTROPHILS. ALSO FOUND IN THE SPLEEN AND TESTIS.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; M76672; AAA58481.1; -.
DR   EMBL; X63819; CAA45319.1; -.
DR   EMBL; M88107; AAA60070.1; -.
DR   EMBL; M84562; AAA52473.1; -.
DR   EMBL; D10922; BAA01720.1; -.
DR   EMBL; U81501; AAB51133.1; -.
DR   EMBL; AF054013; AAC13684.1; -.
DR   EMBL; AC018755; AAF87844.1; -.
DR   PIR; JC1258; JC1258.
DR   PIR; A42492; A42492.
DR   PIR; JQ1521; JQ1521.
DR   PIR; B42009; B42009.
DR   HSSP; P34996; 1DDD.
DR   Genew; HGNC:3827; FPRL1.
DR   MIM; 136538; -.
DR   GO; GO:0016021; C:integral to membrane; TAS.
DR   GO; GO:0005886; C:plasma membrane; TAS.
DR   GO; GO:0004982; F:N-formyl peptide receptor activity; TAS.
DR   GO; GO:0007155; P:cell adhesion; TAS.
DR   GO; GO:0006928; P:cell motility; TAS.
DR   GO; GO:0006935; P:chemotaxis; TAS.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS.
DR   GO; GO:0006954; P:inflammatory response; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Chemotaxis.
FT   DOMAIN        1     27       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     28     50       1 (POTENTIAL).
FT   DOMAIN       51     61       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     62     83       2 (POTENTIAL).
FT   DOMAIN       84    100       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    101    121       3 (POTENTIAL).
FT   DOMAIN      122    140       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    141    162       4 (POTENTIAL).
FT   DOMAIN      163    205       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    206    226       5 (POTENTIAL).
FT   DOMAIN      227    242       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    243    266       6 (POTENTIAL).
FT   DOMAIN      267    286       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    287    306       7 (POTENTIAL).
FT   DOMAIN      307    351       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      4      4       N-LINKED (GLCNAC...) (POTENTIAL).
FT   DISULFID     98    176       POTENTIAL.
FT   CONFLICT    339    339       S -> C (IN REF. 1).
SQ   SEQUENCE   351 AA;  38964 MW;  DC6A1D77AFC0D780 CRC64;
     METNFSTPLN EYEEVSYESA GYTVLRILPL VVLGVTFVLG VLGNGLVIWV AGFRMTRTVT
     TICYLNLALA DFSFTATLPF LIVSMAMGEK WPFGWFLCKL IHIVVDINLF GSVFLIGFIA
     LDRCICVLHP VWAQNHRTVS LAMKVIVGPW ILALVLTLPV FLFLTTVTIP NGDTYCTFNF
     ASWGGTPEER LKVAITMLTA RGIIRFVIGF SLPMSIVAIC YGLIAAKIHK KGMIKSSRPL
     RVLTAVVASF FICWFPFQLV ALLGTVWLKE MLFYGKYKII DILVNPTSSL AFFNSCLNPM
     LYVFVGQDFR ERLIHSLPTS LERALSEDSA PTNDTAANSA SPPAETELQA M
//