ID   IL8A_HUMAN     STANDARD;      PRT;   350 AA.
AC   P25024;
DT   01-MAY-1992 (Rel. 22, Created)
DT   01-MAY-1992 (Rel. 22, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   High affinity interleukin-8 receptor A (IL-8R A) (IL-8 receptor type
DE   1) (CXCR-1) (CDw128a).
GN   IL8RA OR CXCR1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=91368199; PubMed=1840701;
RA   Holmes W.E., Lee J., Kuang W.-J., Rice G.C., Wood W.I.;
RT   "Structure and functional expression of a human interleukin-8
RT   receptor.";
RL   Science 253:1278-1280(1991).
RN   [2]
RP   SEQUENCE FROM N.A., AND CHARACTERIZATION.
RX   MEDLINE=93205012; PubMed=8384312;
RA   Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P.,
RA   Beckmann M.P.;
RT   "Molecular characterization of receptors for human interleukin-8,
RT   GRO/melanoma growth-stimulatory activity and neutrophil activating
RT   peptide-2.";
RL   Mol. Immunol. 30:359-367(1993).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=93252387; PubMed=8486366;
RA   Mollereau C., Passage E., Mattei M.-G., Vassart G., Parmentier M.;
RT   "The high-affinity interleukin 8 receptor gene (IL8RA) maps to the
RT   2q33-q36 region of the human genome: cloning of a pseudogene
RT   (IL8RBP) for the low-affinity receptor.";
RL   Genomics 16:248-251(1993).
RN   [4]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Placenta;
RX   MEDLINE=95014476; PubMed=7929358;
RA   Ahuja S.K., Shetty A., Tiffany H.L., Murphy P.M.;
RT   "Comparison of the genomic organization and promoter function for
RT   human interleukin-8 receptors A and B.";
RL   J. Biol. Chem. 269:26381-26389(1994).
RN   [5]
RP   CHARACTERIZATION.
RX   MEDLINE=92355587; PubMed=1379593;
RA   Lee J., Horuk R., Rice G.C., Bennett G.L., Camerato T., Wood W.I.;
RT   "Characterization of two high affinity human interleukin-8
RT   receptors.";
RL   J. Biol. Chem. 267:16283-16287(1992).
RN   [6]
RP   STRUCTURE BY NMR OF 9-29 IN COMPLEX WITH IL-8.
RX   MEDLINE=99148123; PubMed=10368283;
RA   Skelton N.J., Quan C., Reilly D., Lowman H.;
RT   "Structure of a CXC chemokine-receptor fragment in complex with
RT   interleukin-8.";
RL   Structure 7:157-168(1999).
CC   -!- FUNCTION: RECEPTOR TO INTERLEUKIN-8, WHICH IS A POWERFUL
CC       NEUTROPHILS CHEMOTACTIC FACTOR. BINDING OF IL-8 TO THE RECEPTOR
CC       CAUSES ACTIVATION OF NEUTROPHILS. THIS RESPONSE IS MEDIATED VIA A
CC       G-PROTEIN THAT ACTIVATE A PHOSPHATIDYLINOSITOL-CALCIUM SECOND
CC       MESSENGER SYSTEM. THIS RECEPTOR BINDS TO IL-8 WITH A HIGH AFFINITY
CC       AND TO MGSA (GRO) WITH A LOW AFFINITY.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   -!- DATABASE: NAME=PROW; NOTE=CD guide CDw128a entry;
CC       WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cdw128a.htm".
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
DR   EMBL; L19591; AAB59436.1; -.
DR   EMBL; L19592; AAA59160.1; -.
DR   EMBL; M68932; AAA59159.1; -.
DR   EMBL; X65858; CAA46688.1; -.
DR   EMBL; U11870; AAA64378.1; -.
DR   PIR; A39445; A39445.
DR   PDB; 1ILP; 23-DEC-98.
DR   PDB; 1ILQ; 23-DEC-98.
DR   Genew; HGNC:6026; IL8RA.
DR   MIM; 146929; -.
DR   GO; GO:0004950; F:chemokine receptor activity; TAS.
DR   GO; GO:0004918; F:interleukin-8 receptor activity; TAS.
DR   GO; GO:0006935; P:chemotaxis; TAS.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS.
DR   GO; GO:0006954; P:inflammatory response; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Chemotaxis; Polymorphism; 3D-structure.
FT   DOMAIN        1     39       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     40     66       1 (POTENTIAL).
FT   DOMAIN       67     75       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     76     96       2 (POTENTIAL).
FT   DOMAIN       97    111       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    112    133       3 (POTENTIAL).
FT   DOMAIN      134    154       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    155    174       4 (POTENTIAL).
FT   DOMAIN      175    199       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    200    220       5 (POTENTIAL).
FT   DOMAIN      221    242       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    243    264       6 (POTENTIAL).
FT   DOMAIN      265    285       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    286    308       7 (POTENTIAL).
FT   DOMAIN      309    350       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      3      3       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     16     16       N-LINKED (GLCNAC...) (POTENTIAL).
FT   DISULFID    110    187       BY SIMILARITY.
FT   VARIANT     276    276       T -> S (IN dbSNP:2234671).
FT                                /FTId=VAR_003479.
SQ   SEQUENCE   350 AA;  39805 MW;  2463EEB51BEDD039 CRC64;
     MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF LLSLLGNSLV
     MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV NGWIFGTFLC KVVSLLKEVN
     FYSGILLLAC ISVDRYLAIV HATRTLTQKR HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP
     NNSSPVCYEV LGNDTAKWRM VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA
     MRVIFAVVLI FLLCWLPYNL VLLADTLMRT QVIQETCERR NNIGRALDAT EILGFLHSCL
     NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL
//