ID   IL8A_GORGO     STANDARD;      PRT;   350 AA.
AC   P55919; P55921;
DT   01-NOV-1997 (Rel. 35, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   15-JUL-1998 (Rel. 36, Last annotation update)
DE   High affinity interleukin-8 receptor A (IL-8R A) (IL-8 receptor type
DE   1) (CXCR-1) (CDW128).
GN   IL8RA OR CXCR1.
OS   Gorilla gorilla gorilla (Lowland gorilla), and
OS   Pongo pygmaeus (Orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595, 9600;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96175151; PubMed=9110929;
RA   Alvarez V., Coto E., Setien F., Gonzalez S., Gonzalez-Roces S.,
RA   Lopez-Larrea C.;
RT   "Characterization of interleukin-8 receptors in non-human primates.";
RL   Immunogenetics 43:261-267(1996).
CC   -!- FUNCTION: RECEPTOR TO INTERLEUKIN-8, WHICH IS A POWERFUL
CC       NEUTROPHILS CHEMOTACTIC FACTOR. BINDING OF IL-8 TO THE RECEPTOR
CC       CAUSES ACTIVATION OF NEUTROPHILS. THIS RESPONSE IS MEDIATED VIA A
CC       G-PROTEIN THAT ACTIVATE A PHOSPHATIDYLINOSITOL-CALCIUM SECOND
CC       MESSENGER SYSTEM. THIS RECEPTOR BINDS TO IL-8 WITH A HIGH AFFINITY
CC       AND TO MGSA (GRO) WITH A LOW AFFINITY.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; X91110; CAB37671.1; -.
DR   HSSP; P25024; 1ILP.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Chemotaxis.
FT   DOMAIN        1     39       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     40     66       1 (POTENTIAL).
FT   DOMAIN       67     75       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     76     96       2 (POTENTIAL).
FT   DOMAIN       97    111       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    112    133       3 (POTENTIAL).
FT   DOMAIN      134    154       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    155    174       4 (POTENTIAL).
FT   DOMAIN      175    199       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    200    220       5 (POTENTIAL).
FT   DOMAIN      221    242       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    243    264       6 (POTENTIAL).
FT   DOMAIN      265    285       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    286    308       7 (POTENTIAL).
FT   DOMAIN      309    350       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      3      3       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     16     16       N-LINKED (GLCNAC...) (POTENTIAL).
FT   DISULFID    110    187       BY SIMILARITY.
SQ   SEQUENCE   350 AA;  39790 MW;  DB99591CD6C10757 CRC64;
     MSNITDPQMW DFDDLNFTGM PPIDEDYSPC RLETETLNKY VVIITYALAF LLSLLGNSLV
     MLVILYSRGG RSVTDVYLLN LALADLLFAL TLPIWAASKV NGWIFGTFLC KVVSLLKEVN
     FYSGILLLAC ISVDRYLAIV HATRTLTQKR HLVKFVCLGC WGLSMILSLP FFLFRQAYHP
     NNSSPVCYEV LGNDTAKWRM VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA
     MRVIFAVVLI FLLCWLPYNL VLLADTLMRT QVIQESCERR NNVSLALDAT EILGFLHSCL
     NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL
//