ID   CCR3_HUMAN     STANDARD;      PRT;   368 AA.
AC   P49682; O15185;
DT   01-FEB-1996 (Rel. 33, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (CD183
DE   antigen).
GN   CXCR3 OR GPR9.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Blood;
RX   MEDLINE=97188912; PubMed=9064356;
RA   Loetscher M., Gerber B., Loetscher P., Jones S.A., Piali L.,
RA   Clark-Lewis I., Baggiolini M., Moser B.;
RT   "Chemokine receptor specific for IP10 and mig: structure, function,
RT   and expression in activated T-lymphocytes.";
RL   J. Exp. Med. 184:963-969(1996).
RN   [2]
RP   SEQUENCE FROM N.A.
RA   Gutierrez J., Varona R., Zaballos A., Lind P., Marquez G.;
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain, Lung, and Testis;
RX   MEDLINE=22388257; PubMed=12477932;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length
RT   human and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [4]
RP   SEQUENCE OF 5-368 FROM N.A.
RX   MEDLINE=96115583; PubMed=8666380;
RA   Marchese A., Heiber M., Nguyen T., Heng H.H.Q., Saldivia V.R.,
RA   Cheng R., Murphy P.M., Tsui L.-C., Shi X., Gregor P., George S.R.,
RA   O'Dowd B.F., Docherty J.M.;
RT   "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10,
RT   and GPR14, encoding receptors related to interleukin 8, neuropeptide
RT   Y, and somatostatin receptors.";
RL   Genomics 29:335-344(1995).
RN   [5]
RP   LIGAND BINDING.
RC   TISSUE=Fetal astrocytes;
RX   MEDLINE=98290735; PubMed=9625760;
RA   Cole K.E., Strick C.A., Paradis T.J., Ogborne K.T., Loetscher M.,
RA   Gladue R.P., Lin W., Boyd J.G., Moser B., Wood D.E., Sahagan B.G.,
RA   Neote K.;
RT   "Interferon-inducible T cell alpha chemoattractant (I-TAC): A novel
RT   non-ELR CXC chemokine with potent activity on activated T cells
RT   through selective high affinity binding to CXCR3.";
RL   J. Exp. Med. 187:2009-2021(1998).
CC   -!- FUNCTION: RECEPTOR FOR SCYB9/MIG, SCYB10/INP10 AND SCYB11/ITAC.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   -!- DATABASE: NAME=PROW; NOTE=PROW 1:78-83(2000);
CC       WWW="http://www.ncbi.nlm.nih.gov/prow/guide/650534941_g.htm".
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DR   EMBL; X95876; CAA65126.1; -.
DR   EMBL; Z79783; CAB02143.1; ALT_INIT.
DR   EMBL; BC034403; AAH34403.1; -.
DR   EMBL; U32674; AAC50505.1; -.
DR   Genew; HGNC:4540; CXCR3.
DR   MIM; 600894; -.
DR   GO; GO:0005737; C:cytoplasm; TAS.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0006960; P:antimicrobial humoral response (sensu Inver...; TAS.
DR   GO; GO:0007155; P:cell adhesion; TAS.
DR   GO; GO:0006928; P:cell motility; TAS.
DR   GO; GO:0006935; P:chemotaxis; TAS.
DR   GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS.
DR   InterPro; IPR004070; CXC_chemkine3.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR01532; CXCCHMKINER3.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein; Antigen.
FT   DOMAIN        1     53       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     54     80       1 (POTENTIAL).
FT   DOMAIN       81     89       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     90    110       2 (POTENTIAL).
FT   DOMAIN      111    125       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    126    147       3 (POTENTIAL).
FT   DOMAIN      148    169       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    170    189       4 (POTENTIAL).
FT   DOMAIN      190    212       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    213    233       5 (POTENTIAL).
FT   DOMAIN      234    255       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    256    277       6 (POTENTIAL).
FT   DOMAIN      278    298       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    299    321       7 (POTENTIAL).
FT   DOMAIN      322    368       CYTOPLASMIC (POTENTIAL).
FT   DISULFID    124    203       BY SIMILARITY.
FT   CARBOHYD     22     22       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     32     32       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CONFLICT     75     75       A -> R (IN REF. 2).
SQ   SEQUENCE   368 AA;  40659 MW;  F08A3B44B2BBAD04 CRC64;
     MVLEVSDHQV LNDAEVAALL ENFSSSYDYG ENESDSCCTS PPCPQDFSLN FDRAFLPALY
     SLLFLLGLLG NGAVAAVLLS RRTALSSTDT FLLHLAVADT LLVLTLPLWA VDAAVQWVFG
     SGLCKVAGAL FNINFYAGAL LLACISFDRY LNIVHATQLY RRGPPARVTL TCLAVWGLCL
     LFALPDFIFL SAHHDERLNA THCQYNFPQV GRTALRVLQL VAGFLLPLLV MAYCYAHILA
     VLLVSRGQRR LRAMRLVVVV VVAFALCWTP YHLVVLVDIL MDLGALARNC GRESRVDVAK
     SVTSGLGYMH CCLNPLLYAF VGVKFRERMW MLLLRLGCPN QRGLQRQPSS SRRDSSWSET
     SEASYSGL
//