ID   CKR1_HUMAN     STANDARD;      PRT;   355 AA.
AC   P32246;
DT   01-OCT-1993 (Rel. 27, Created)
DT   01-OCT-1993 (Rel. 27, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1)
DE   (Macrophage inflammatory protein-1 alpha receptor) (MIP-1alpha-R)
DE   (RANTES-R) (HM145) (LD78 receptor).
GN   CCR1 OR CMKBR1 OR CMKR1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=93161416; PubMed=7679328;
RA   Neote K., Digregorio D., Mak J.Y., Horuk R., Schall T.J.;
RT   "Molecular cloning, functional expression, and signaling
RT   characteristics of a C-C chemokine receptor.";
RL   Cell 72:415-425(1993).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=93240122; PubMed=7683036;
RA   Gao J.-L., Kuhns D., Tiffany H.L., McDermott D., Li X., Francke U.,
RA   Murphy P.M.;
RT   "Structure and functional expression of the human macrophage
RT   inflammatory protein 1 alpha/RANTES receptor.";
RL   J. Exp. Med. 177:1421-1427(1993).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Monocytes;
RX   MEDLINE=94092629; PubMed=7505609;
RA   Nomura H., Nielsen B.W., Matsushima K.;
RT   "Molecular cloning of cDNAs encoding a LD78 receptor and putative
RT   leukocyte chemotactic peptide receptors.";
RL   Int. Immunol. 5:1239-1249(1993).
CC   -!- FUNCTION: RECEPTOR FOR A C-C TYPE CHEMOKINE. BINDS TO MIP-1-ALPHA,
CC       MIP-1 DELTA, RANTES, AND MCP-3 AND, LESS EFFICIENTLY, TO MIP-1-
CC       BETA OR MCP-1 AND SUBSEQUENTLY TRANSDUCES A SIGNAL BY INCREASING
CC       THE INTRACELLULAR CALCIUM IONS LEVEL. RESPONSIBLE FOR AFFECTING
CC       STEM CELL PROLIFERATION.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: WIDELY EXPRESSED IN DIFFERENT HEMATOPOIETIC
CC       CELLS.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
DR   EMBL; L09230; AAA58408.1; -.
DR   EMBL; L10918; AAA36543.1; -.
DR   EMBL; D10925; BAA01723.1; -.
DR   PIR; A45177; A45177.
DR   Genew; HGNC:1602; CCR1.
DR   MIM; 601159; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004950; F:chemokine receptor activity; TAS.
DR   GO; GO:0007155; P:cell adhesion; TAS.
DR   GO; GO:0007267; P:cell-cell signaling; TAS.
DR   GO; GO:0006935; P:chemotaxis; TAS.
DR   GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS.
DR   GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS.
DR   GO; GO:0006955; P:immune response; TAS.
DR   GO; GO:0006954; P:inflammatory response; TAS.
DR   GO; GO:0007125; P:invasive growth; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein.
FT   DOMAIN        1     34       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     35     60       1 (POTENTIAL).
FT   DOMAIN       61     64       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     65     91       2 (POTENTIAL).
FT   DOMAIN       92    107       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    108    129       3 (POTENTIAL).
FT   DOMAIN      130    146       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    147    171       4 (POTENTIAL).
FT   DOMAIN      172    197       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    198    223       5 (POTENTIAL).
FT   DOMAIN      224    239       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    240    264       6 (POTENTIAL).
FT   DOMAIN      265    281       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    282    305       7 (POTENTIAL).
FT   DOMAIN      306    355       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      5      5       N-LINKED (GLCNAC...) (POTENTIAL).
FT   DISULFID    106    183       BY SIMILARITY.
FT   CONFLICT    337    337       E -> D (IN REF. 3).
SQ   SEQUENCE   355 AA;  41172 MW;  B2C100FFED275985 CRC64;
     METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV GNILVVLVLV
     QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV FGDAMCKILS GFYYTGLYSE
     IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIIIWAL AILASMPGLY FSKTQWEFTH
     HTCSLHFPHE SLREWKLFQA LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL
     IFVIMIIFFL FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI
     YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE LSAGF
//