ID   CKR1_MOUSE     STANDARD;      PRT;   355 AA.
AC   P51675; Q91VP9;
DT   01-OCT-1996 (Rel. 34, Created)
DT   01-OCT-1996 (Rel. 34, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1)
DE   (Macrophage inflammatory protein-1 alpha receptor) (MIP-1alpha-R)
DE   (RANTES-R).
GN   CCR1 OR CMKBR1.
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=129/Sv; TISSUE=Peritoneal macrophage;
RX   MEDLINE=96072806; PubMed=7594543;
RA   Post T.W., Bozic C.R., Rothenberg M.E., Luster A.D., Gerard N.,
RA   Gerard C.;
RT   "Molecular characterization of two murine eosinophil beta chemokine
RT   receptors.";
RL   J. Immunol. 155:5299-5305(1995).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   STRAIN=129/SvJ;
RX   MEDLINE=95340546; PubMed=7542241;
RA   Gao J.-L., Murphy P.M.;
RT   "Cloning and differential tissue-specific expression of three mouse
RT   beta chemokine receptor-like genes, including the gene for a
RT   functional macrophage inflammatory protein-1 alpha receptor.";
RL   J. Biol. Chem. 270:17494-17501(1995).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Breast;
RX   MEDLINE=22388257; PubMed=12477932;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length
RT   human and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: RECEPTOR FOR A C-C TYPE CHEMOKINE. BINDS TO MIP-1-ALPHA,
CC       RANTES, AND LESS EFFICIENTLY, TO MIP-1-BETA OR MCP-1 AND
CC       SUBSEQUENTLY TRANSDUCES A SIGNAL BY INCREASING THE INTRACELLULAR
CC       CALCIUM IONS LEVEL. RESPONSIBLE FOR AFFECTING STEM CELL
CC       PROLIFERATION.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: DETECTED IN THE HEART, SPLEEN, LUNG,
CC       PERITONEAL EXUDATE CELLS AND LEUKOCYTES.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
DR   EMBL; U29678; AAA86119.1; -.
DR   EMBL; U28404; AAA89153.1; -.
DR   EMBL; BC011092; AAH11092.1; -.
DR   MGD; MGI:104618; Ccr1.
DR   GO; GO:0016493; F:C-C chemokine receptor activity; IDA.
DR   GO; GO:0005515; F:protein binding activity; IPI.
DR   GO; GO:0030595; P:immune cell chemotaxis; IDA.
DR   GO; GO:0006954; P:inflammatory response; IMP.
DR   GO; GO:0030099; P:myeloid blood cell differentiation; IMP.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane.
FT   DOMAIN        1     34       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     35     60       1 (POTENTIAL).
FT   DOMAIN       61     64       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     65     91       2 (POTENTIAL).
FT   DOMAIN       92    107       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    108    129       3 (POTENTIAL).
FT   DOMAIN      130    146       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    147    171       4 (POTENTIAL).
FT   DOMAIN      172    197       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    198    223       5 (POTENTIAL).
FT   DOMAIN      224    239       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    240    264       6 (POTENTIAL).
FT   DOMAIN      265    281       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    282    305       7 (POTENTIAL).
FT   DOMAIN      306    355       CYTOPLASMIC (POTENTIAL).
FT   DISULFID    106    183       BY SIMILARITY.
FT   CONFLICT     55     55       M -> V (IN REF. 2 AND 3).
FT   CONFLICT    149    149       L -> F (IN REF. 3).
FT   CONFLICT    278    278       H -> Q (IN REF. 3).
SQ   SEQUENCE   355 AA;  40901 MW;  FCE9FFF70E6F38B1 CRC64;
     MEISDFTEAY PTTTEFDYGD STPCQKTAVR AFGAGLLPPL YSLVFIIGVV GNVLMILVLM
     QHRRLQSMTS IYLFNLAVSD LVFLFTLPFW IDYKLKDDWI FGDAMCKLLS GFYYLGLYSE
     IFFIILLTID RYLAIVHAVF ALRARTVTLG IITSIITWAL AILASMPALY FFKAQWEFTH
     RTCSPHFPYK SLKQWKRFQA LKLNLLGLIL PLLVMIICYA GIIRILLRRP SEKKVKAVRL
     IFAITLLFFL LWTPYNLSVF VSAFQDVLFT NQCEQSKHLD LAMQVTEVIA YTHCCVNPII
     YVFVGERFWK YLRQLFQRHV AIPLAKWLPF LSVDQLERTS SISPSTGEHE LSAGF
//