ID   CKR2_HUMAN     STANDARD;      PRT;   374 AA.
AC   P41597;
DT   01-NOV-1995 (Rel. 32, Created)
DT   01-NOV-1995 (Rel. 32, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2)
DE   (Monocyte chemoattractant protein 1 receptor) (MCP-1-R).
GN   CCR2 OR CMKBR2.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=94195821; PubMed=8146186;
RA   Charo I.F., Myers S.J., Herman A., Franci C., Connolly A.J.,
RA   Coughlin S.R.;
RT   "Molecular cloning and functional expression of two monocyte
RT   chemoattractant protein 1 receptors reveals alternative splicing of
RT   the carboxyl-terminal tails.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:2752-2756(1994).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=94324942; PubMed=8048929;
RA   Yamagami S., Tokuda Y., Ishii K., Tamaka H., Endo N.;
RT   "cDNA cloning and functional expression of a human monocyte
RT   chemoattractant protein 1 receptor.";
RL   Biochem. Biophys. Res. Commun. 202:1156-1162(1994).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=97150864; PubMed=8995400;
RA   Wong L.-M., Myers S.J., Tsou C.-L., Gosling J., Arai H., Charo I.F.;
RT   "Organization and differential expression of the human monocyte
RT   chemoattractant protein 1 receptor gene. Evidence for the role of the
RT   carboxyl-terminal tail in receptor trafficking.";
RL   J. Biol. Chem. 272:1038-1045(1997).
RN   [4]
RP   SEQUENCE FROM N.A.
RA   McCombie W.R., Wilson R., Chen E., Gibbs R., Zuo L., Johnson D.,
RA   Nhan M., Parnell L., Dedhia N., Ansari A., Mardis E., Schutz K.,
RA   Gnoj L., la Bastide M., Kaplan N., Greco T., Touchman J.,
RA   Muzny D., Chen C.N., Evans C., Fitzgerald M., See L.H., Tang M.,
RA   Porcel B.M., Dragan Y., Giacalone J., Pae A., Powell E.,
RA   Solinsky K.A., Desilva U., Diaz-Perez S., Zhou X., Yu Y.,
RA   Watanabe M., Doggett N., Garcia D., Sagripanti J.L.;
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   SEQUENCE FROM N.A., AND VARIANTS ILE.64 AND GLU-355.
RA   Rieder M.J., Armel T.Z., Carrington D.P., Ozuna M., Kuldanek S.A.,
RA   Rajkumar N., Toth E.J., Yi Q., Nickerson D.A.;
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   SULFATION OF TYR-26, AND N-GLYCOSYLATION.
RX   MEDLINE=20501139; PubMed=11046064;
RA   Preobrazhensky A.A., Dragan S., Kawano T., Gavrilin M.A., Gulina I.V.,
RA   Chakravarty L., Kolattukudy P.E.;
RT   "Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that
RT   has tyrosine sulfation in a conserved extracellular N-terminal
RT   region.";
RL   J. Immunol. 165:5295-5303(2000).
CC   -!- FUNCTION: Receptor for the MCP-1, MCP-3 and MCP-4 chemokines.
CC       Transduces a signal by increasing the intracellular calcium ions
CC       level. Alternative coreceptor with CD4 for HIV-1 infection.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=A;
CC         IsoId=P41597-1; Sequence=Displayed;
CC       Name=B;
CC         IsoId=P41597-2; Sequence=VSP_001893;
CC   -!- PTM: N-GLYCOSYLATED.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; U03882; AAA19119.1; -.
DR   EMBL; U03905; AAA19120.1; -.
DR   EMBL; D29984; BAA06253.1; -.
DR   EMBL; U80924; AAC51637.1; -.
DR   EMBL; U80924; AAC51636.1; -.
DR   EMBL; U95626; AAB57791.1; -.
DR   EMBL; U95626; AAB57792.1; -.
DR   EMBL; AF545480; AAN16400.1; -.
DR   Genew; HGNC:1603; CCR2.
DR   MIM; 601267; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0005625; C:soluble fraction; TAS.
DR   GO; GO:0004950; F:chemokine receptor activity; TAS.
DR   GO; GO:0006960; P:antimicrobial humoral response (sensu Inver...; TAS.
DR   GO; GO:0006968; P:cellular defense response; TAS.
DR   GO; GO:0006935; P:chemotaxis; TAS.
DR   GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS.
DR   GO; GO:0006954; P:inflammatory response; TAS.
DR   GO; GO:0007125; P:invasive growth; TAS.
DR   GO; GO:0007259; P:JAK-STAT cascade; TAS.
DR   GO; GO:0007194; P:negative regulation of adenylate cyclase ac...; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein; Sulfation;
KW   Polymorphism; Alternative splicing.
FT   DOMAIN        1     42       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     43     70       1 (POTENTIAL).
FT   DOMAIN       71     80       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     81    100       2 (POTENTIAL).
FT   DOMAIN      101    114       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    115    136       3 (POTENTIAL).
FT   DOMAIN      137    153       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    154    178       4 (POTENTIAL).
FT   DOMAIN      179    206       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    207    226       5 (POTENTIAL).
FT   DOMAIN      227    243       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    244    268       6 (POTENTIAL).
FT   DOMAIN      269    285       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    286    309       7 (POTENTIAL).
FT   DOMAIN      310    374       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     14     14       N-LINKED (GLCNAC...) (POTENTIAL).
FT   MOD_RES      26     26       SULFATION.
FT   DISULFID    113    190       BY SIMILARITY.
FT   VARSPLIC    314    374       SLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGR
FT                                GKGKSIGRAPEASLQDKEGA -> RYLSVFFRKHITKRFCK
FT                                QCPVFYRETVDGVTSTNTPSTGEQEVSAGL (in
FT                                isoform B).
FT                                /FTId=VSP_001893.
FT   VARIANT      64     64       V -> I (IN dbSNP:1799864).
FT                                /FTId=VAR_014339.
FT   VARIANT     355    355       G -> E.
FT                                /FTId=VAR_014340.
SQ   SEQUENCE   374 AA;  41914 MW;  F865E0D39E74CF0F CRC64;
     MLSTSRSRFI RNTNESGEEV TTFFDYDYGA PCHKFDVKQI GAQLLPPLYS LVFIFGFVGN
     MLVVLILINC KKLKCLTDIY LLNLAISDLL FLITLPLWAH SAANEWVFGN AMCKLFTGLY
     HIGYFGGIFF IILLTIDRYL AIVHAVFALK ARTVTFGVVT SVITWLVAVF ASVPGIIFTK
     CQKEDSVYVC GPYFPRGWNN FHTIMRNILG LVLPLLIMVI CYSGILKTLL RCRNEKKRHR
     AVRVIFTIMI VYFLFWTPYN IVILLNTFQE FFGLSNCEST SQLDQATQVT ETLGMTHCCI
     NPIIYAFVGE KFRSLFHIAL GCRIAPLQKP VCGGPGVRPG KNVKVTTQGL LDGRGKGKSI
     GRAPEASLQD KEGA
//