ID   CXC1_HUMAN     STANDARD;      PRT;   333 AA.
AC   P46094;
DT   01-NOV-1995 (Rel. 32, Created)
DT   01-NOV-1995 (Rel. 32, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   Chemokine XC receptor 1 (XC chemokine receptor 1) (Lymphotactin
DE   receptor) (G protein-coupled receptor GPR5).
GN   XCR1 OR CCXCR1 OR GPR5.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=95134353; PubMed=7832990;
RA   Heiber M., Docherty J.M., Shah G., Nguyen T., Cheng R.,
RA   Heng H.H.Q., Marchese A., Tsui L.-C., Shi X., George S.R.,
RA   O'Dowd B.F.;
RT   "Isolation of three novel human genes encoding G protein-coupled
RT   receptors.";
RL   DNA Cell Biol. 14:25-35(1995).
RN   [2]
RP   CHARACTERIZATION.
RX   MEDLINE=98298178; PubMed=9632725;
RA   Yoshida T., Imai T., Kakizaki M., Nishimura M., Takagi S., Yoshie O.;
RT   "Identification of single C motif-1/lymphotactin receptor XCR1.";
RL   J. Biol. Chem. 273:16551-16554(1998).
CC   -!- FUNCTION: RECEPTOR FOR CHEMOKINES SCYC1 AND SCYC2. SUBSEQUENTLY
CC       TRANSDUCES A SIGNAL BY INCREASING THE INTRACELLULAR CALCIUM IONS
CC       LEVEL.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; L36149; AAA62837.1; -.
DR   Genew; HGNC:1625; XCR1.
DR   MIM; 600552; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004950; F:chemokine receptor activity; TAS.
DR   GO; GO:0006960; P:antimicrobial humoral response (sensu Inver...; TAS.
DR   GO; GO:0006935; P:chemotaxis; TAS.
DR   GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS.
DR   GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS.
DR   GO; GO:0006954; P:inflammatory response; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR005393; Lymphotactinr.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01568; LYMPHOTACTNR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane.
FT   DOMAIN        1     31       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     32     59       1 (POTENTIAL).
FT   DOMAIN       60     69       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     70     89       2 (POTENTIAL).
FT   DOMAIN       90    103       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    104    125       3 (POTENTIAL).
FT   DOMAIN      126    142       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    143    167       4 (POTENTIAL).
FT   DOMAIN      168    190       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    191    209       5 (POTENTIAL).
FT   DOMAIN      210    225       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    226    250       6 (POTENTIAL).
FT   DOMAIN      251    267       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    268    291       7 (POTENTIAL).
FT   DOMAIN      292    333       CYTOPLASMIC (POTENTIAL).
FT   DISULFID    102    175       BY SIMILARITY.
SQ   SEQUENCE   333 AA;  38507 MW;  C84E7A3EF919CFA5 CRC64;
     MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS LVLWVLVKYE
     SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF LCKLLNMIFS ISLYSSIFFL
     TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT MAVWVASILS SILDTIFHKV LSSGCDYSEL
     TWYLTSVYQH NLFFLLSLGI ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP
     YNFTLFLQTL FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH
     VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY
//