ID   C3X1_HUMAN     STANDARD;      PRT;   355 AA.
AC   P49238;
DT   01-FEB-1996 (Rel. 33, Created)
DT   01-FEB-1996 (Rel. 33, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Fractalkine
DE   receptor) (GPR13) (V28) (Beta chemokine receptor-like 1) (CMK-BRL-1)
DE   (CMKBLR1).
GN   CX3CR1 OR GPR13.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96011651; PubMed=7590284;
RA   Raport C.J., Schweickart V.L., Eddy R.L. Jr., Shows T.B., Gray P.W.;
RT   "The orphan G-protein-coupled receptor-encoding gene V28 is closely
RT   related to genes for chemokine receptors and is expressed in lymphoid
RT   and neural tissues.";
RL   Gene 163:295-299(1995).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=95374679; PubMed=7646814;
RA   Combadiere C., Ahuja S.K., Murphy P.M.;
RT   "Cloning, chromosomal localization, and RNA expression of a human
RT   beta chemokine receptor-like gene.";
RL   DNA Cell Biol. 14:673-680(1995).
RN   [3]
RP   CHARACTERIZATION.
RX   MEDLINE=98050927; PubMed=9390561;
RA   Imai T., Hieshima K., Haskell C., Baba M., Nagira M., Nishimura M.,
RA   Kakizaki M., Takagi S., Nomiyama H., Schall T.J., Yoshie O.;
RT   "Identification and molecular characterization of fractalkine receptor
RT   CX3CR1, which mediates both leukocyte migration and adhesion.";
RL   Cell 91:521-530(1997).
RN   [4]
RP   CHARACTERIZATION.
RX   MEDLINE=98395093; PubMed=9726990;
RA   Combadiere C., Salzwedel K., Smith E.D., Tiffany H.L., Berger E.A.,
RA   Murphy P.M.;
RT   "Identification of CX3CR1. A chemotactic receptor for the human CX3C
RT   chemokine fractalkine and a fusion coreceptor for HIV-1.";
RL   J. Biol. Chem. 273:23799-23804(1998).
RN   [5]
RP   VARIANTS ALA-57; ILE-122; ILE-249 AND MET-280.
RX   MEDLINE=20196025; PubMed=10731151;
RA   Faure S., Meyer L., Costagliola D., Vaneensberghe C., Genin E.,
RA   Autran B., Delfraissy J.-F., McDermott D.H., Murphy P.M., Debre P.,
RA   Theodorou I., Combadiere C.;
RT   "Rapid progression to AIDS in HIV+ individuals with a structural
RT   variant of the chemokine receptor CX3CR1.";
RL   Science 287:2274-2277(2000).
CC   -!- FUNCTION: RECEPTOR FOR THE CX3C CHEMOKINE FRACTALKINE AND MEDIATES
CC       BOTH ITS ADHESIVE AND MIGRATORY FUNCTIONS. ACTS AS CO-RECEPTOR
CC       WITH CD4 FOR HIV-1 VIRUS ENVELOPE PROTEIN (IN VITRO).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: EXPRESSED IN LYMPHOID AND NEURAL TISSUES.
CC   -!- DISEASE: INCREASED SUSCEPTIBILITY TO HIV INFECTION AND RAPID
CC       PROGRESSION TO AIDS ARE ASSOCIATED WITH THE I-249/M-280 HAPLOTYPE.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; U20350; AAA91783.1; -.
DR   EMBL; U28934; AAA87032.1; -.
DR   Genew; HGNC:2558; CX3CR1.
DR   MIM; 601470; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004950; F:chemokine receptor activity; TAS.
DR   GO; GO:0007155; P:cell adhesion; TAS.
DR   GO; GO:0006968; P:cellular defense response; TAS.
DR   GO; GO:0006935; P:chemotaxis; TAS.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS.
DR   InterPro; IPR005387; Fractalkiner.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR01562; FRACTALKINER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Polymorphism.
FT   DOMAIN        1     31       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     32     59       1 (POTENTIAL).
FT   DOMAIN       60     69       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     70     90       2 (POTENTIAL).
FT   DOMAIN       91    103       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    104    125       3 (POTENTIAL).
FT   DOMAIN      126    142       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    143    167       4 (POTENTIAL).
FT   DOMAIN      168    195       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    196    215       5 (POTENTIAL).
FT   DOMAIN      216    231       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    232    256       6 (POTENTIAL).
FT   DOMAIN      257    273       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    274    297       7 (POTENTIAL).
FT   DOMAIN      298    355       CYTOPLASMIC (POTENTIAL).
FT   DISULFID    102    175       BY SIMILARITY.
FT   VARIANT      57     57       T -> A.
FT                                /FTId=VAR_010041.
FT   VARIANT     122    122       V -> I.
FT                                /FTId=VAR_010042.
FT   VARIANT     249    249       V -> I (COMMON POLYMORPHISM IN CAUCASIAN
FT                                POPULATION).
FT                                /FTId=VAR_010043.
FT   VARIANT     280    280       T -> M (COMMON POLYMORPHISM IN CAUCASIAN
FT                                POPULATION).
FT                                /FTId=VAR_010044.
SQ   SEQUENCE   355 AA;  40396 MW;  C59DC5F4C4312F22 CRC64;
     MDQFPESVTE NFEYDDLAEA CYIGDIVVFG TVFLSIFYSV IFAIGLVGNL LVVFALTNSK
     KPKSVTDIYL LNLALSDLLF VATLPFWTHY LINEKGLHNA MCKFTTAFFF IGFFGSIFFI
     TVISIDRYLA IVLAANSMNN RTVQHGVTIS LGVWAAAILV AAPQFMFTKQ KENECLGDYP
     EVLQEIWPVL RNVETNFLGF LLPLLIMSYC YFRIIQTLFS CKNHKKAKAI KLILLVVIVF
     FLFWTPYNVM IFLETLKLYD FFPSCDMRKD LRLALSVTET VAFSHCCLNP LIYAFAGEKF
     RRYLYHLYGK CLAVLCGRSV HVDFSSSESQ RSRHGSVLSS NFTYHTSDGD ALLLL
//