ID   COXD_BOVIN     STANDARD;      PRT;    97 AA.
AC   P07471;
DT   01-APR-1988 (Rel. 07, Created)
DT   01-MAY-1992 (Rel. 22, Last sequence update)
DT   15-JUN-2002 (Rel. 41, Last annotation update)
DE   Cytochrome c oxidase polypeptide VIa-heart, mitochondrial precursor
DE   (EC 1.9.3.1) (COXVIAH) (Polypeptide VIb).
GN   COX6A2 OR COX6A.
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea;
OC   Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Heart;
RX   MEDLINE=91274363; PubMed=1647214;
RA   Smith E.O., Bement D.M., Grossman L.I., Lomax M.I.;
RT   "The cDNA for the heart/muscle isoform of bovine cytochrome c oxidase
RT   subunit VIa encodes a presequence.";
RL   Biochim. Biophys. Acta 1089:266-268(1991).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=93326637; PubMed=7687470;
RA   Smith E.O., Lomax M.I.;
RT   "Structural organization of the bovine gene for the heart/muscle
RT   isoform of cytochrome c oxidase subunit VIa.";
RL   Biochim. Biophys. Acta 1174:63-71(1993).
RN   [3]
RP   SEQUENCE OF 13-96.
RC   TISSUE=Heart;
RX   MEDLINE=86000134; PubMed=2994692;
RA   Meinecke L., Buse G.;
RT   "Studies on cytochrome c oxidase, XII. Isolation and primary
RT   structure of polypeptide VIb from bovine heart.";
RL   Biol. Chem. Hoppe-Seyler 366:687-694(1985).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
RX   MEDLINE=96216288; PubMed=8638158;
RA   Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H.,
RA   Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.;
RT   "The whole structure of the 13-subunit oxidized cytochrome c oxidase
RT   at 2.8 A.";
RL   Science 272:1136-1144(1996).
RN   [5]
RP   X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
RC   TISSUE=Heart;
RX   MEDLINE=99190827; PubMed=10089392;
RA   Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T.,
RA   Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.;
RT   "Structure analysis of bovine heart cytochrome c oxidase at 2.8 A
RT   resolution.";
RL   Acta Crystallogr. D 55:31-45(1999).
RN   [6]
RP   X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
RC   TISSUE=Heart;
RX   MEDLINE=20235645; PubMed=10771420;
RA   Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T.,
RA   Shinzawa-Itoh K., Nakashima R., Yoshikawa S.;
RT   "X-ray structure of azide-bound fully oxidized cytochrome c oxidase
RT   from bovine heart at 2.9 A resolution.";
RL   Acta Crystallogr. D 56:529-535(2000).
CC   -!- FUNCTION: THIS PROTEIN IS ONE OF THE NUCLEAR-CODED POLYPEPTIDE
CC       CHAINS OF CYTOCHROME C OXIDASE, THE TERMINAL OXIDASE IN
CC       MITOCHONDRIAL ELECTRON TRANSPORT.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) = 4 ferricytochrome
CC       c + 2 H(2)O.
CC   -!- SUBCELLULAR LOCATION: Mitochondrial inner membrane.
CC   -!- TISSUE SPECIFICITY: HEART/MUSCLE SPECIFIC ISOFORM.
CC   -!- SIMILARITY: BELONGS TO THE CYTOCHROME C OXIDASE VIA FAMILY.
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DR   EMBL; S64127; AAB27605.1; -.
DR   EMBL; X56857; CAA40183.1; -.
DR   PIR; A24659; A24659.
DR   PIR; S16242; S16242.
DR   PIR; S35702; S35702.
DR   PDB; 1OCC; 07-DEC-96.
DR   PDB; 2OCC; 13-JAN-99.
DR   PDB; 1OCR; 29-JUL-99.
DR   PDB; 1OCO; 22-JUL-99.
DR   PDB; 1OCZ; 22-JUL-99.
DR   InterPro; IPR001349; COX6A.
DR   Pfam; PF02046; COX6A; 1.
DR   ProDom; PD006036; COX6A; 1.
DR   PROSITE; PS01329; COX6A; 1.
KW   Oxidoreductase; Inner membrane; Mitochondrion; Transit peptide;
KW   3D-structure; Transmembrane.
FT   TRANSIT       1     12       MITOCHONDRION.
FT   CHAIN        13     97       CYTOCHROME C OXIDASE POLYPEPTIDE VIA-
FT                                HEART.
FT   DOMAIN       13     24       MITOCHONDRIAL MATRIX.
FT   TRANSMEM     25     49
FT   DOMAIN       50     97       MITOCHONDRIAL INTERMEMBRANE.
SQ   SEQUENCE   97 AA;  10800 MW;  59B408A1B9B6AF4F CRC64;
     MALPLKSLSR GLASAAKGDH GGTGARTWRF LTFGLALPSV ALCTLNSWLH SGHRERPAFI
     PYHHLRIRTK PFSWGDGNHT FFHNPRVNPL PTGYEKP
//