ID   CCKR_HUMAN     STANDARD;      PRT;   428 AA.
AC   P32238;
DT   01-OCT-1993 (Rel. 27, Created)
DT   01-OCT-1993 (Rel. 27, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Cholecystokinin type A receptor (CCK-A receptor) (CCK-AR).
GN   CCKAR OR CCKRA.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Gall bladder;
RX   MEDLINE=93277552; PubMed=8503909;
RA   Ulrich C.D., Ferber I., Holicky E., Hadac E., Buell G.,
RA   Miller L.J.;
RT   "Molecular cloning and functional expression of the human gallbladder
RT   cholecystokinin A receptor.";
RL   Biochem. Biophys. Res. Commun. 193:204-211(1993).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=93343941; PubMed=8343165;
RA   Wank S.A., de Weerth A., Pisegna J.R., Huppi K.;
RT   "Molecular cloning, functional expression and chromosomal
RT   localization of the human cholecystokinin type A receptor.";
RL   Biochem. Biophys. Res. Commun. 194:811-818(1993).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96029343; PubMed=7557108;
RA   Miller L.J., Holicky E.L., Ulrich C.D., Wieben E.D.;
RT   "Abnormal processing of the human cholecystokinin receptor gene in
RT   association with gallstones and obesity.";
RL   Gastroenterology 109:1375-1380(1995).
RN   [4]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Peripheral blood leukocytes;
RX   MEDLINE=20145045; PubMed=10682840;
RA   Funakoshi A., Miyasaka K., Matsumoto H., Yamamori S., Takiguchi S.,
RA   Kataoka K., Takata Y., Matsusue K., Kono A., Shimokata H.;
RT   "Gene structure of human cholecystokinin (CCK) type-A receptor: body
RT   fat content is related to CCK type-A receptor gene promoter
RT   polymorphism.";
RL   FEBS Lett. 466:264-266(2000).
CC   -!- FUNCTION: RECEPTOR FOR CHOLECYSTOKININ. HAS A 1000 FOLD AFFINITY
CC       FOR CCK RATHER THAN FOR GASTRIN. IT MODULATES FEEDING AND
CC       DOPAMINE-INDUCED BEHAVIOR IN THE CENTRAL AND PERIPHERAL NERVOUS
CC       SYSTEM. THIS RECEPTOR MEDIATES ITS ACTION BY ASSOCIATION WITH G
CC       PROTEINS THAT ACTIVATE A PHOSPHATIDYLINOSITOL-CALCIUM SECOND
CC       MESSENGER SYSTEM.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; L13605; AAA35659.1; -.
DR   EMBL; L19315; AAA02819.1; -.
DR   EMBL; U23430; AAA91123.1; -.
DR   EMBL; U23427; AAA91123.1; JOINED.
DR   EMBL; U23428; AAA91123.1; JOINED.
DR   EMBL; U23429; AAA91123.1; JOINED.
DR   EMBL; D85606; BAA90879.1; -.
DR   PIR; JN0590; JN0590.
DR   PIR; JN0692; JN0692.
DR   HSSP; P02699; 1F88.
DR   Genew; HGNC:1570; CCKAR.
DR   MIM; 118444; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004951; F:cholecystokinin receptor activity; TAS.
DR   GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS.
DR   GO; GO:0007586; P:digestion; TAS.
DR   GO; GO:0007631; P:feeding behavior; TAS.
DR   GO; GO:0007584; P:nutritional response pathway; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Lipoprotein; Palmitate.
FT   DOMAIN        1     41       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     42     67       1 (POTENTIAL).
FT   DOMAIN       68     77       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     78    104       2 (POTENTIAL).
FT   DOMAIN      105    115       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    116    137       3 (POTENTIAL).
FT   DOMAIN      138    157       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    158    178       4 (POTENTIAL).
FT   DOMAIN      179    210       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    211    234       5 (POTENTIAL).
FT   DOMAIN      235    313       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    314    334       6 (POTENTIAL).
FT   DOMAIN      335    349       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    350    373       7 (POTENTIAL).
FT   DOMAIN      374    428       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     10     10       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     24     24       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    190    190       N-LINKED (GLCNAC...) (POTENTIAL).
FT   DISULFID    114    196       BY SIMILARITY.
FT   LIPID       387    387       PALMITATE (BY SIMILARITY).
SQ   SEQUENCE   428 AA;  47841 MW;  A6E8FABDA805E610 CRC64;
     MDVVDSLLVN GSNITPPCEL GLENETLFCL DQPRPSKEWQ PAVQILLYSL IFLLSVLGNT
     LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI PNLLKDFIFG SAVCKTTTYF
     MGTSVSVSTF NLVAISLERY GAICKPLQSR VWQTKSHALK VIAATWCLSF TIMTPYPIYS
     NLVPFTKNNN QTANMCRFLL PNDVMQQSWH TFLLLILFLI PGIVMMVAYG LISLELYQGI
     KFEASQKKSA KERKPSTTSS GKYEDSDGCY LQKTRPPRKL ELRQLSTGSS SRANRIRSNS
     SAANLMAKKR VIRMLIVIVV LFFLCWMPIF SANAWRAYDT ASAERRLSGT PISFILLLSY
     TSSCVNPIIY CFMNKRFRLG FMATFPCCPN PGPPGARGEV GEEEEGGTTG ASLSRFSYSH
     MSASVPPQ
//