ID   CLT1_HUMAN     STANDARD;      PRT;   337 AA.
AC   Q9Y271;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4
DE   receptor) (LTD4 receptor) (HG55) (HMTMF81).
GN   CYSLTR1 OR CYSLT1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Tonsil;
RX   MEDLINE=99318129; PubMed=10391245;
RA   Lynch K.R., O'Neill G.P., Liu Q., Im D.-S., Sawyer N., Metters K.M.,
RA   Coulombe N., Abramovitz M., Figueroa D.J., Zeng Z., Connolly B.M.,
RA   Bai C., Austin C.P., Chateauneuf A., Stocco R., Greig G.M.,
RA   Kargman S., Hooks S.B., Hosfield E., Williams D.L. Jr.,
RA   Ford-Hutchinson A.W., Caskey C.T., Evans J.F.;
RT   "Characterization of the human cysteinyl leukotriene CysLT1
RT   receptor.";
RL   Nature 399:789-793(1999).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Leukocyte, Peripheral blood monocytes, and Spleen;
RX   MEDLINE=99393629; PubMed=10462554;
RA   Sarau H.M., Ames R.S., Chambers J., Ellis C., Elshourbagy N.,
RA   Foley J.J., Schmidt D.B., Muccitelli R.M., Jenkins O., Murdock P.R.,
RA   Herrity N.C., Halsey W., Sathe G., Muir A.I., Nuthulaganti P.,
RA   Dytko G.M., Buckley P.T., Wilson S., Bergsma D.J., Hay D.W.P.;
RT   "Identification, molecular cloning, expression, and characterization
RT   of a cysteinyl leukotriene receptor.";
RL   Mol. Pharmacol. 56:657-663(1999).
CC   -!- FUNCTION: Receptor for cysteinyl leukotrienes mediating
CC       bronchoconstriction of individuals with and without asthma.
CC       Stimulation by LTD4 results in the contraction and proliferation
CC       of smooth muscle, edema, eosinophil migration and damage to the
CC       mucus layer in the lung. This response is mediated via a G-protein
CC       that activates a phosphatidylinositol-calcium second messenger
CC       system. The rank order of affinities for the leukotrienes is LTD4
CC       >> LTE4 = LTC4 >> LTB4.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in
CC       spleen and peripheral blood leukocytes. Lower expression in
CC       several tissues, such as lung (mostly in smooth muscle bundles
CC       and alveolar macrophages), placenta, small intestine, pancreas,
CC       colon and heart.
CC   -!- MISCELLANEOUS: Selective antagonists, such as montelukast
CC       (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are
CC       used in the treatment of the asthma crisis.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
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CC   the European Bioinformatics Institute.  There are no  restrictions on  its
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CC   modified and this statement is not removed.  Usage  by  and for commercial
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DR   EMBL; AF119711; AAD42285.1; -.
DR   EMBL; AF133266; AAD42778.1; -.
DR   HSSP; P34996; 1DDD.
DR   Genew; HGNC:17451; CYSLTR1.
DR   MIM; 300201; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0005624; C:membrane fraction; TAS.
DR   GO; GO:0004974; F:leukotriene receptor activity; TAS.
DR   GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS.
DR   GO; GO:0006952; P:defense response; TAS.
DR   GO; GO:0007585; P:respiratory gaseous exchange; TAS.
DR   InterPro; IPR004071; Cysleuk_receptor.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR01533; CYSLTRECPTR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein.
FT   DOMAIN        1     28       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     29     49       1 (POTENTIAL).
FT   DOMAIN       50     57       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     58     78       2 (POTENTIAL).
FT   DOMAIN       79    106       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    107    127       3 (POTENTIAL).
FT   DOMAIN      128    141       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    142    162       4 (POTENTIAL).
FT   DOMAIN      163    193       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    194    214       5 (POTENTIAL).
FT   DOMAIN      215    230       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    231    251       6 (POTENTIAL).
FT   DOMAIN      252    276       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    277    297       7 (POTENTIAL).
FT   DOMAIN      298    337       CYTOPLASMIC (POTENTIAL).
FT   DISULFID     96    173       BY SIMILARITY.
FT   CARBOHYD      6      6       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    169    169       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    180    180       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    262    262       N-LINKED (GLCNAC...) (POTENTIAL).
SQ   SEQUENCE   337 AA;  38541 MW;  B9B53940F895F245 CRC64;
     MDETGNLTVS SATCHDTIDD FRNQVYSTLY SMISVVGFFG NGFVLYVLIK TYHKKSAFQV
     YMINLAVADL LCVCTLPLRV VYYVHKGIWL FGDFLCRLST YALYVNLYCS IFFMTAMSFF
     RCIAIVFPVQ NINLVTQKKA RFVCVGIWIF VILTSSPFLM AKPQKDEKNN TKCFEPPQDN
     QTKNHVLVLH YVSLFVGFII PFVIIIVCYT MIILTLLKKS MKKNLSSHKK AIGMIMVVTA
     AFLVSFMPYH IQRTIHLHFL HNETKPCDSV LRMQKSVVIT LSLAASNCCF DPLLYFFSGG
     NFRKRLSTFR KHSLSSVTYV PRKKASLPEK GEEICKV
//