ID   CLT1_MOUSE     STANDARD;      PRT;   352 AA.
AC   Q99JA4; Q9JJ71; Q9JK47;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4
DE   receptor) (LTD4 receptor).
GN   CYSLTR1 OR CYSLT1 OR CYSLT1R.
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORMS 1 AND 2).
RC   STRAIN=129/Sv;
RX   PubMed=11226226;
RA   Maekawa A., Kanaoka Y., Lam B.K., Austen K.F.;
RT   "Identification in mice of two isoforms of the cysteinyl leukotriene 1
RT   receptor that result from alternative splicing.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:2256-2261(2001).
RN   [2]
RP   SEQUENCE FROM N.A. (ISOFORM 1).
RC   STRAIN=C57BL/6; TISSUE=Trachea;
RX   MEDLINE=21562332; PubMed=11705452;
RA   Martin V., Sawyer N., Stocco R., Unett D., Lerner M.R., Abramovitz M.,
RA   Funk C.D.;
RT   "Molecular cloning and functional characterization of murine
RT   cysteinyl-leukotriene 1 (CysLT1) receptors.";
RL   Biochem. Pharmacol. 62:1193-1200(2001).
RN   [3]
RP   SEQUENCE FROM N.A. (ISOFORM 1).
RC   TISSUE=Blood;
RX   MEDLINE=21240338; PubMed=11342226;
RA   Mollerup J., Jorgensen S.T., Hougaard C., Hoffmann E.K.;
RT   "Identification of a murine cysteinyl leukotriene receptor by
RT   expression in Xenopus laevis oocytes.";
RL   Biochim. Biophys. Acta 1517:455-459(2001).
RN   [4]
RP   SEQUENCE FROM N.A. (ISOFORM 2).
RC   TISSUE=T-cell;
RA   Ogasawara H., Izumi T., Shimizu T.;
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for cysteinyl leukotrienes mediating
CC       constriction of the microvascular smooth muscle during an
CC       inflammatory response. This response is mediated via a G-protein
CC       that activates a phosphatidylinositol-calcium second messenger
CC       system. The rank order of affinities for the leukotrienes is LTD4
CC       >> LTE4 = LTC4 >> LTB4.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Long;
CC         IsoId=Q99JA4-1; Sequence=Displayed;
CC       Name=2; Synonyms=Short;
CC         IsoId=Q99JA4-2; Sequence=VSP_001921;
CC   -!- TISSUE SPECIFICITY: Widely expressed, with higher expression in
CC       the lung and skin, intermediate levels in the heart, kidney and
CC       stomach and lower levels in several other tissues. Isoform 1 is
CC       the most abundant form in all tested tissues.
CC   -!- MISCELLANEOUS: MK-571, a selective antagonist, was shown to
CC       inhibit eosinophilia, bronchial hyperreactivity and microvascular
CC       leakage. Zafirlukast (Accolate) and pranlukast (Onon) were also
CC       shown to be selective antagonists.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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CC   the European Bioinformatics Institute.  There are no  restrictions on  its
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CC   modified and this statement is not removed.  Usage  by  and for commercial
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DR   EMBL; AF329272; AAK16715.1; -.
DR   EMBL; AF329272; AAK16716.1; -.
DR   EMBL; AF205830; AAK15433.1; -.
DR   EMBL; AF263370; AAF73047.1; -.
DR   EMBL; AB044087; BAA96809.1; -.
DR   HSSP; P34996; 1DDD.
DR   MGD; MGI:1926218; Cysltr1.
DR   GO; GO:0005887; C:integral to plasma membrane; IDA.
DR   GO; GO:0004974; F:leukotriene receptor activity; IDA.
DR   InterPro; IPR004071; Cysleuk_receptor.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR01533; CYSLTRECPTR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Alternative splicing.
FT   DOMAIN        1     43       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     44     64       1 (POTENTIAL).
FT   DOMAIN       65     72       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     73     93       2 (POTENTIAL).
FT   DOMAIN       94    121       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    122    142       3 (POTENTIAL).
FT   DOMAIN      143    156       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    157    177       4 (POTENTIAL).
FT   DOMAIN      178    208       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    209    229       5 (POTENTIAL).
FT   DOMAIN      230    245       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    246    266       6 (POTENTIAL).
FT   DOMAIN      267    291       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    292    312       7 (POTENTIAL).
FT   DOMAIN      313    352       CYTOPLASMIC (POTENTIAL).
FT   DISULFID    111    188       BY SIMILARITY.
FT   CARBOHYD     15     15       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     19     19       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     26     26       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    184    184       N-LINKED (GLCNAC...) (POTENTIAL).
FT   VARSPLIC      1     13       Missing (in isoform 2).
FT                                /FTId=VSP_001921.
FT   CONFLICT    176    176       Y -> D (IN REF. 3).
SQ   SEQUENCE   352 AA;  40715 MW;  5BDC94B3F1CD0CAB CRC64;
     MYLQGTKQTF LENMNGTENL TTSLINNTCH DTIDEFRNQV YSTMYSVISV VGFFGNSFVL
     YVLIKTYHEK SAFQVYMINL AIADLLCVCT LPLRVVYYVH KGKWLFGDFL CRLTTYALYV
     NLYCSIFFMT AMSFFRCVAI VFPVQNINLV TQKKARFVCI GIWIFVILTS SPFLMYKSYQ
     DEKNNTKCFE PPQNNQAKKY VLILHYVSLF FGFIIPFVTI IVCYTMIILT LLKNTMKKNM
     PSRRKAIGMI IVVTAAFLVS FMPYHIQRTI HLHLLHSETR PCDSVLRMQK SVVITLSLAA
     SNCCFDPLLY FFSGGNFRRR LSTFRKHSLS SMTYVPKKKA SLPEKGEEIC NE
//