ID   DADR_HUMAN     STANDARD;      PRT;   446 AA.
AC   P21728;
DT   01-MAY-1991 (Rel. 18, Created)
DT   01-MAY-1991 (Rel. 18, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   D(1A) dopamine receptor.
GN   DRD1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=90370093; PubMed=2144334;
RA   Dearry A., Gingrich J.A., Falardeau P., Fremeau R.T. Jr., Bates M.D.,
RA   Caron M.G.;
RT   "Molecular cloning and expression of the gene for a human D1 dopamine
RT   receptor.";
RL   Nature 347:72-76(1990).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=90370094; PubMed=2168520;
RA   Zhou Q.-Y., Grandy D.K., Thambi L., Kushner J.A., van Tol H.H.M.,
RA   Cone R., Pribnow D., Salon J., Bunzow J.R., Civelli O.;
RT   "Cloning and expression of human and rat D1 dopamine receptors.";
RL   Nature 347:76-80(1990).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=90370095; PubMed=1975640;
RA   Sunahara R.K., Niznik H.B., Weiner D.M., Stormann T.M., Brann M.R.,
RA   Kennedy J.L., Gelernter J.E., Rozmahel R., Yang Y., Israel Y.,
RA   Seeman P., O'Dowd B.F.;
RT   "Human dopamine D1 receptor encoded by an intronless gene on
RT   chromosome 5.";
RL   Nature 347:80-83(1990).
RN   [4]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain;
RX   MEDLINE=93228762; PubMed=8471124;
RA   Ohara K., Ulpian C., Seeman P., Sunahara R.K., van Tol H.H.M.,
RA   Niznik H.B.;
RT   "Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA
RT   polymorphisms.";
RL   Neuropsychopharmacology 8:131-135(1993).
RN   [5]
RP   SEQUENCE FROM N.A.
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain;
RA   Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   PALMITOYLATION OF CYS-347 AND CYS-351.
RX   MEDLINE=20086865; PubMed=10618483;
RA   Jin H., Xie Z., George S.R., O'Dowd B.F.;
RT   "Palmitoylation occurs at cysteine 347 and cysteine 351 of the
RT   dopamine D(1) receptor.";
RL   Eur. J. Pharmacol. 386:305-312(1999).
CC   -!- FUNCTION: THIS IS ONE OF THE FIVE TYPES (D1 TO D5) OF RECEPTORS
CC       FOR DOPAMINE. THE ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G
CC       PROTEINS WHICH ACTIVATE ADENYLYL CYCLASE.
CC   -!- SUBUNIT: Interacts with calcyon.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
DR   EMBL; X55758; CAA39284.1; -.
DR   EMBL; X55760; CAA39286.1; -.
DR   EMBL; X58987; CAA41734.1; -.
DR   EMBL; S58541; AAB26273.1; -.
DR   EMBL; AB065677; BAC05902.1; -.
DR   EMBL; AF498961; AAM18131.1; -.
DR   PIR; S11377; DYHUD1.
DR   Genew; HGNC:3020; DRD1.
DR   MIM; 126449; -.
DR   GO; GO:0005623; C:cell; TAS.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004952; F:dopamine receptor activity; TAS.
DR   GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS.
DR   GO; GO:0007212; P:dopamine receptor signaling pathway; TAS.
DR   GO; GO:0007191; P:dopamine receptor, adenylate cyclase activa...; TAS.
DR   GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS.
DR   GO; GO:0007268; P:synaptic transmission; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Multigene family; Lipoprotein; Palmitate; Polymorphism.
FT   DOMAIN        1     23       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     24     49       1 (POTENTIAL).
FT   DOMAIN       50     60       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     61     87       2 (POTENTIAL).
FT   DOMAIN       88     96       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     97    119       3 (POTENTIAL).
FT   DOMAIN      120    138       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    139    163       4 (POTENTIAL).
FT   DOMAIN      164    192       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    193    218       5 (POTENTIAL).
FT   DOMAIN      219    272       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    273    299       6 (POTENTIAL).
FT   DOMAIN      300    312       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    313    337       7 (POTENTIAL).
FT   DOMAIN      338    446       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      5      5       N-LINKED (GLCNAC...) (POTENTIAL).
FT   DISULFID     96    186       BY SIMILARITY.
FT   LIPID       347    347       PALMITATE.
FT   LIPID       351    351       PALMITATE.
FT   VARIANT      37     37       T -> P (IN dbSNP:5327).
FT                                /FTId=VAR_014670.
FT   VARIANT      37     37       T -> R (IN dbSNP:5328).
FT                                /FTId=VAR_014671.
FT   VARIANT      50     50       R -> S (IN dbSNP:5330).
FT                                /FTId=VAR_014672.
FT   VARIANT     199    199       S -> A (IN dbSNP:5331).
FT                                /FTId=VAR_014673.
FT   CONFLICT    438    438       I -> M (IN REF. 2).
SQ   SEQUENCE   446 AA;  49293 MW;  64E062D765D0DBA7 CRC64;
     MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR FRHLRSKVTN
     FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV AFDIMCSTAS ILNLCVISVD
     RYWAISSPFR YERKMTPKAA FILISVAWTL SVLISFIPVQ LSWHKAKPTS PSDGNATSLA
     ETIDNCDSSL SRTYAISSSV ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN
     CQTTTGNGKP VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS
     GETQPFCIDS NTFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL CPATNNAIET
     VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED LKKEEAAGIA RPLEKLSPAL
     SVILDYDTDV SLEKIQPITQ NGQHPT
//