ID   ET1R_BOVIN     STANDARD;      PRT;   427 AA.
AC   P21450;
DT   01-MAY-1991 (Rel. 18, Created)
DT   01-AUG-1991 (Rel. 19, Last sequence update)
DT   01-FEB-1996 (Rel. 33, Last annotation update)
DE   Endothelin-1 receptor precursor (ET-A).
GN   EDNRA.
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea;
OC   Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Lung;
RX   MEDLINE=91080923; PubMed=2175396;
RA   Arai H., Hori S., Aramori I., Ohkubo H., Nakanishi S.;
RT   "Cloning and expression of a cDNA encoding an endothelin receptor.";
RL   Nature 348:730-732(1990).
CC   -!- FUNCTION: RECEPTOR FOR ENDOTHELIN-1. MEDIATES ITS ACTION BY
CC       ASSOCIATION WITH G PROTEINS THAT ACTIVATE A PHOSPHATIDYLINOSITOL-
CC       CALCIUM SECOND MESSENGER SYSTEM. THE RANK ORDER OF BINDING
CC       AFFINITIES FOR ET-A IS: ET1 > ET2 >> ET3.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; X57765; CAA40917.1; -.
DR   PIR; S13424; S13424.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein; Signal.
FT   SIGNAL        1     17       POTENTIAL.
FT   CHAIN        18    427       ENDOTHELIN-1 RECEPTOR.
FT   DOMAIN       18     80       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     81    102       1 (POTENTIAL).
FT   DOMAIN      103    112       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    113    132       2 (POTENTIAL).
FT   DOMAIN      133    159       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    160    181       3 (POTENTIAL).
FT   DOMAIN      182    205       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    206    229       4 (POTENTIAL).
FT   DOMAIN      230    256       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    257    278       5 (POTENTIAL).
FT   DOMAIN      279    306       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    307    328       6 (POTENTIAL).
FT   DOMAIN      329    347       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    348    372       7 (POTENTIAL).
FT   DOMAIN      373    427       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     29     29       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     62     62       N-LINKED (GLCNAC...) (POTENTIAL).
FT   DISULFID    158    239       BY SIMILARITY.
SQ   SEQUENCE   427 AA;  48515 MW;  73CF44404CD9AC14 CRC64;
     METFWLRLSF WVALVGGVIS DNPESYSTNL SIHVDSVATF HGTELSFVVT THQPTNLALP
     SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA
     SLALGDLIYV VIDLPINVFK LLAGRWPFEQ NDFGVFLCKL FPFLQKSSVG ITVLNLCALS
     VDRYRAVASW SRVQGIGIPL VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGAQHRTCM
     LNATSKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
     RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDTNR CELLSFLLLM DYIGINLATM
     NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM NGTSIQWKNH EQNNHNTERS
     SHKDSIN
//