ID   ET1R_HUMAN     STANDARD;      PRT;   427 AA.
AC   P25101; Q8TBH2;
DT   01-MAY-1992 (Rel. 22, Created)
DT   01-MAY-1992 (Rel. 22, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   Endothelin-1 receptor precursor (ET-A).
GN   EDNRA OR ETRA OR ETA.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Placenta;
RX   MEDLINE=92062153; PubMed=1719979;
RA   Adachi M., Yang Y.Y., Furuichi Y., Miyamoto C.;
RT   "Cloning and characterization of cDNA encoding human A-type
RT   endothelin receptor.";
RL   Biochem. Biophys. Res. Commun. 180:1265-1272(1991).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Placenta;
RX   MEDLINE=92068188; PubMed=1659806;
RA   Cyr C., Huebner K., Druck T., Kris R.;
RT   "Cloning and chromosomal localization of a human endothelin ETA
RT   receptor.";
RL   Biochem. Biophys. Res. Commun. 181:184-190(1991).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=91348221; PubMed=1652463;
RA   Hosoda K., Nakao K., Arai H., Suga S., Ogawa Y., Mukoyama M.,
RA   Shirakami G., Saito Y., Nakanishi S., Imura H.;
RT   "Cloning and expression of human endothelin-1 receptor cDNA.";
RL   FEBS Lett. 287:23-26(1991).
RN   [4]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=93180293; PubMed=1291713;
RA   Arai H., Nakao K., Hosoda K., Ogawa Y., Nakagawa O., Komatsu Y.,
RA   Imura H.;
RT   "Molecular cloning of human endothelin receptors and their expression
RT   in vascular endothelial cells and smooth muscle cells.";
RL   Jpn. Circ. J. 56:1303-1307(1992).
RN   [5]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=93179382; PubMed=8440682;
RA   Elshourbagy N.A., Korman D.R., Wu H.L., Sylvester D.R., Lee J.A.,
RA   Nuthalaganti P., Bergsma D.J., Kumar C.S., Nambi P.;
RT   "Molecular characterization and regulation of the human endothelin
RT   receptors.";
RL   J. Biol. Chem. 268:3873-3879(1993).
RN   [6]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=92406798; PubMed=1326535;
RA   Hosoda K., Nakao K., Tamura N., Arai H., Ogawa Y., Suga S.,
RA   Nakanishi S., Imura H.;
RT   "Organization, structure, chromosomal assignment, and expression of
RT   the gene encoding the human endothelin-A receptor.";
RL   J. Biol. Chem. 267:18797-18804(1992).
RN   [7]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Placenta;
RX   MEDLINE=93035452; PubMed=1415318;
RA   Hayzer D.J., Rose P.M., Lynch J.S., Webb M.L., Kienzle B.K., Liu E.C.,
RA   Bogosian E.A., Brinson E., Runge M.S.;
RT   "Cloning and expression of a human endothelin receptor: subtype A.";
RL   Am. J. Med. Sci. 304:231-238(1992).
RN   [8]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Lung;
RX   MEDLINE=96190719; PubMed=8611157;
RA   Miyamoto Y., Yoshimasa T., Arai H., Takaya K., Ogawa Y., Itoh H.,
RA   Nakao K.;
RT   "Alternative RNA splicing of the human endothelin-A receptor
RT   generates multiple transcripts.";
RL   Biochem. J. 313:795-801(1996).
RN   [9]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain;
RX   MEDLINE=22388257; PubMed=12477932;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length
RT   human and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [10]
RP   SEQUENCE OF 1-140 FROM N.A.
RX   MEDLINE=93151811; PubMed=8427579;
RA   Yang H., Tabuchi H., Furuichi Y., Miyamoto C.;
RT   "Molecular characterization of the 5'-flanking region of human
RT   genomic ETA gene.";
RL   Biochem. Biophys. Res. Commun. 190:332-339(1993).
CC   -!- FUNCTION: RECEPTOR FOR ENDOTHELIN-1. MEDIATES ITS ACTION BY
CC       ASSOCIATION WITH G PROTEINS THAT ACTIVATE A PHOSPHATIDYLINOSITOL-
CC       CALCIUM SECOND MESSENGER SYSTEM. THE RANK ORDER OF BINDING
CC       AFFINITIES FOR ET-A IS: ET1 > ET2 >> ET3.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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DR   EMBL; D90348; BAA14359.1; -.
DR   EMBL; L06622; AAA58447.1; -.
DR   EMBL; X61950; CAA43953.1; -.
DR   EMBL; S67127; AAB20407.1; -.
DR   EMBL; S63938; AAB20278.1; -.
DR   EMBL; S57498; AAB25530.2; -.
DR   EMBL; D11151; BAA01920.1; -.
DR   EMBL; D11145; BAA01920.1; JOINED.
DR   EMBL; D11146; BAA01920.1; JOINED.
DR   EMBL; D11147; BAA01920.1; JOINED.
DR   EMBL; D11148; BAA01920.1; JOINED.
DR   EMBL; D11149; BAA01920.1; JOINED.
DR   EMBL; D11150; BAA01920.1; JOINED.
DR   EMBL; S45956; AAB23644.1; -.
DR   EMBL; S81539; AAB36325.1; -.
DR   EMBL; BC022511; AAH22511.1; -.
DR   EMBL; S55772; AAB25212.1; -.
DR   PIR; JS0607; JS0607.
DR   PIR; JT0972; JT0972.
DR   PIR; S16980; S16980.
DR   PIR; A44158; A44158.
DR   PIR; A45481; A45481.
DR   Genew; HGNC:3179; EDNRA.
DR   MIM; 131243; -.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS.
DR   GO; GO:0004962; F:endothelin receptor activity; TAS.
DR   GO; GO:0007190; P:adenylate cyclase activation; TAS.
DR   GO; GO:0008283; P:cell proliferation; TAS.
DR   GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS.
DR   GO; GO:0007203; P:phosphatidylinositol-4,5-bisphosphate hydro...; TAS.
DR   GO; GO:0007202; P:phospholipase C activation; TAS.
DR   GO; GO:0007165; P:signal transduction; TAS.
DR   GO; GO:0006939; P:smooth muscle contraction; TAS.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein; Signal.
FT   SIGNAL        1     17       POTENTIAL.
FT   CHAIN        18    427       ENDOTHELIN-1 RECEPTOR.
FT   DOMAIN       18     80       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     81    102       1 (POTENTIAL).
FT   DOMAIN      103    112       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    113    132       2 (POTENTIAL).
FT   DOMAIN      133    159       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    160    181       3 (POTENTIAL).
FT   DOMAIN      182    205       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    206    229       4 (POTENTIAL).
FT   DOMAIN      230    256       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    257    278       5 (POTENTIAL).
FT   DOMAIN      279    306       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    307    328       6 (POTENTIAL).
FT   DOMAIN      329    347       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    348    372       7 (POTENTIAL).
FT   DOMAIN      373    427       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     29     29       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     62     62       N-LINKED (GLCNAC...) (POTENTIAL).
FT   DISULFID    158    239       BY SIMILARITY.
FT   CONFLICT    110    110       C -> Y (IN REF. 7).
FT   CONFLICT    115    115       P -> H (IN REF. 9).
FT   CONFLICT    207    207       V -> A (IN REF. 5).
FT   CONFLICT    234    234       E -> G (IN REF. 5).
FT   CONFLICT    280    280       C -> G (IN REF. 5).
FT   CONFLICT    322    322       L -> V (IN REF. 9).
FT   CONFLICT    409    409       N -> D (IN REF. 9).
SQ   SEQUENCE   427 AA;  48722 MW;  207272D4A231404F CRC64;
     METLCLRASF WLALVGCVIS DNPERYSTNL SNHVDDFTTF RGTELSFLVT THQPTNLVLP
     SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA
     SLALGDLIYV VIDLPINVFK LLAGRWPFDH NDFGVFLCKL FPFLQKSSVG ITVLNLCALS
     VDRYRAVASW SRVQGIGIPL VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YRGEQHKTCM
     LNATSKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
     RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYNEMDKNR CELLSFLLLM DYIGINLATM
     NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM NGTSIQWKNH DQNNHNTDRS
     SHKDSMN
//