C.J. Huang Research Group @ NTU

Journal Publications

2024

B. Cao, Y. Yang, M. Liu† and C. Huang†, Linear strain gradient-regulated bifurcation of circular bilayer plates, Extreme Mechanics Letters, 72: 102250, 2024.
Y. Yang, B. Cao, Y. Tang and C. Huang†, One-pot fabrication of bio-inspired Shape-Morphing bilayer structures, Chemical Engineering Journal, 500: 156735, 2024.
S. Chin, Y. Chen, L. Zhao, X. Liu, C.-P. Chng, A. Soman, L. Nordenskiöld, C. Huang†, X. Shi†, K. Xue†, Investigating Different Dynamic pHP1α States in Their KCl-Mediated Liquid–Liquid Phase Separation (LLPS) Using Solid-State NMR (SSNMR) and Molecular Dynamic (MD) Simulations, The Journal of Physical Chemistry B, 128: 10451-10459, 2024.
G. Fang, B. Ho, H. Xu, C. Gong, Z. Qiao, Y. Liao, S. Zhu, H. Lu, N. Nie, T. Zhou, M. Kim, C. Huang, B. Soh and Y.-C. Chen, Compressible Hollow Microlasers in Organoids for High-Throughput and Real-Time Mechanical Screening, ACS Nano, 18: 26338-26349, 2024.
C.-P. Chng, L. Zhang, S. Gupta† and C. Huang†, Palmitoylation enhances short polar peptide permeation across stratum corneum lipid bilayer: A molecular dynamics study, Extreme Mechanics Letters, 71: 102213, 2024.
C.-P. Chng, S. Gupta† and C. Huang†, Protonation State of a Bioactive Compound Regulates Its Release from Lamellar Gel-Phase Bilayers, Journal of Physical Chemistry B, 128: 7180–7187, 2024.
Y. Song, Q. Hu, S. Liu, Y. Wang, L. Jia, X. Hu, C. Huang† and H. Zhang†, 3D printed biomimetic composite scaffolds with sequential releasing of copper ions and dexamethasone for cascade regulation of angiogenesis and osteogenesis, Chemical Engineering Journal, 496: 153662, 2024.
R. Zhou, C. Huang, N. Srikanth, L. Bai and M. Wu, Nanoindentation behavior in T-carbon thin films: A molecular dynamics study, Acta Mechanica Sinica, doi: 10.1007/s10409-024-24222-x, 2024.
R. Zhou, L. Bai, C. Huang, N. Srikanth and M. Wu, Strain hardening behavior in T-carbon: A molecular dynamics study, Materials & Design, 242: 113028, 2024.
B.T. Safa, C. Huang, A. Kabla and R. Yang, Active Viscoelastic Models for Cell and Tissue Mechanics, Royal Society Open Science, 11:231074, 2024.
Y. Yang, Y. Wang, M. Lin, M. Liu† and C. Huang†, Bio-inspired facile strategy for programmable osmosis-driven shape-morphing elastomer composite structures, Materials Horizons, 11: 2180-2190, 2024.
Q. Zhou, C.-P. Chng, Y. Zhao, H. Xu, Y. Huo and C. Huang†, Ethanol-induced gelation enables direct three-dimensional printing of sodium alginate hydrogel, Materials & Design, 239: 112746, 2024.
J. Kumar, C.-P. Chng and C. Huang†, Curvature-enhanced membrane asymmetry slows down protein diffusion, Extreme Mechanics Letters, 66: 102114, 2024.

2023

J. Kumar, C.-P. Chng and C. Huang†, Hydrophobic Matching Dictates over the Linear Rule of Mixtures in Binary Lipid Membranes, The Journal of Physical Chemistry B, 127: 7946-7954, 2023.
X. Jin, J. Rosenbohm, E. Kim, K. Seiffert-Sinha, M. Leiker, S.R. Baddam, G. Minnick, Y. Huo, B. Tajvidi Safa, H. Zhai, J.K. Wahl III, F. Meng, C. Huang, J. Lim, D.E. Conway, A.A. Sinha and R. Yang, Desmosome Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions, iScience, doi: 10.2139/ssrn.4557199, 2023.
P. Fattahi, Y.‐T. Yeh, T. Zhao, M. Younesi, C. Huang, M. Terrones, S. Zheng, J.L. Brown, D. Huh, S. Zhang and P.J. Butler, Endothelial Cell Selectivity to Nanoparticles Depends on Mechanical Phenotype, Advanced Materials Interfaces, 10: 2300137, 2023.
H. Xu, Y. Huo, Q. Zhou, A. Wang, P. Cai, B. Doss, C. Huang† and K.J. Hsia†, Geometry-mediated bridging drives non-adhesive stripe wound healing, Proceedings of the National Academy of Sciences of the United States of America, 120: e2221040120, 2023.
M. Wang, Q. Li, C. Shi, J. Lv, Y. Xu, J. Yang, S. Chua, L. Jia, H. Chen, Q. Liu, C. Huang, Y. Huang, J. Chen and M. Fang, Oligomer nanoparticle release from polylactic acid plastics catalysed by gut enzymes triggers acute inflammation, Nature Nanotechnology, 18: 403-411, 2023.

2022

C. Chng, K.J. Hsia† and C. Huang†, Modulation of lipid vesicle-membrane interaction by cholesterol, Soft Matter, 18: 7752-7761, 2022.
C. Gong, F. Sun, G. Yang, C. Wang, C. Huang and Y.‐C. Chen, Multifunctional Laser Imaging of Cancer Cell Secretion with Hybrid Liquid Crystal Resonators, Laser & Photonics Reviews, 16: 2100734, 2022.
K. Guo, C. Huang, Y. Miao, D. J. Cosgrove† and K.J. Hsia†, Leaf morphogenesis: the multifaceted roles of mechanics, Molecular Plant, 15(7): 1098-1119, 2022.
C. Chng, K. Wang, W. Ma, K.J. Hsia and C. Huang†, Chloroplast membrane lipid remodeling protects against dehydration by limiting membrane fusion and distortion, Plant Physiology, kiab512, 2022.
T. M. Tran, C. Chng, X. Pu, Z. Ma, X. Han, X. Liu, L. Yang, C.Huang† and Y. Miao†, Potentiation of plant defense by bacterial outer membrane vesicles is mediated by membrane nanodomain, The Plant Cell, koab276, 2022.
Z. Qiao, H. Xu, N. Zhang, X. Gong, C. Gong, G. Yang, S. Chew, C.Huang† and Y.-C. Chen†, Cellular Features Revealed by Transverse Laser Modes in Frequency Domain, Advanced Science, 2103550, 2022.
C. Huang†, H. Li, J. Powell, Y. Ouyang, S.G. Wendell, S. Suresh, K.J. Hsia†, Y. Sadovsky† and D. Quinn†, Assessing hypoxic damage to placental trophoblasts by measuring membrane viscosity of extracellular vesicles, Placenta, 121： 14-22，2022.
H. Xu, H. Tae, N-J. Cho†, C. Huang† and K.J. Hsia†, Thermodynamic Modeling of Solvent-Assisted Lipid Bilayer Formation Process, Micromachines, 13(1): 134, 2022.
K. Kajiwara, O. Beharier, C.-P. Chng, J. P. Goff, Y. OUYANG, C. M. St Croix, C. Huang, V. E. E Kagan, K. J. Hsia, and Y. Sadovsky, Ferroptosis Induces Membrane Blebbing in Placental Trophoblasts, Journal of Cell Science, jcs.255737 doi: 10.1242/jcs.255737, 2022.

2021

C. Chng, N-J. Cho, K.J. Hsia† and C. Huang†, Role of Membrane Stretch in Adsorption of Antiviral Peptides onto Lipid Membranes and Membrane Pore Formation, Langmuir, DOI: 10.1021/acs.langmuir.1c02067, 2021.
Z. Zhao, J. Kumar, Y. Hwang, J. Deng, M.S. Ibrahim, C. Huang, S. Suresh, and N-J. Cho, Digital Printing of Shape-Morphing Natural Materials, Proceedings of the National Academy of Sciences of the United States of America, 118 (43): e2113715118, 2021.
A. M. Esfahani, J. Rosenbohm, B. T. Safa, N. V. Lavrik†, G. Minnick, Q. Zhou, F. Kong, X. Jin, E. Kim, Y. Liu, Y. Lu, J. Y. Lim, J. K. Wahl III, M. Dao†, C. Huang†, and R. Yang†, Characterization of the Strain Rate-Dependent Mechanical Response of Single Cell-Cell Junctions, Proceedings of the National Academy of Sciences of the United States of America, 118 (7): e2019347118, 2021.
C. Chng, Y. Sadovsky, K.J. Hsia† and C. Huang†, Curvature-regulated lipid membrane softening of nano-vesicles, Extreme Mechanics Letters, 43: 101174, 2021.
C. Chng, Y. Sadovsky, K.J. Hsia† and C. Huang†, Site-specific peroxidation modulates lipid bilayer mechanics, Extreme Mechanics Letters, 42: 101148, 2021.

2020

X. Gong, Z. Qiao, P. Guan, S. Feng, Z. Yuan, C. Huang, G. Chang and Y.-C. Chen, Hydrogel Microlasers for Versatile Biomolecular Analysis Based on a Lasing Microarray, Advanced Photonics Research, 1: 2000041, 2020.
Q. Wei, X. Shi, T. Zhao, P. Cai, T. Chen, Y. Zhang, C. Huang, J. Yang, X. Chen, and S. Zhang, Actin-ring segment switching drives nonadhesive gap closure, Proceedings of the National Academy of Sciences of the United States of America, 117: 33263-33271, 2020.

2019

A. Kalmykov, C. Huang, J. Bliley, D. Shiwarski, J. Tashman, A. Abdullah, S. Rastogi, E. Mataev, A. W. Feinberg, K. J. Hsia and T. Cohen-Karni, Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids, Science Advances, 5: eaax0729, 2019.
Y. Zhang, X. Shi, T. Zhao, C. Huang, Q. Wei, X. Tang, L.C. Santy, M.T.A Saif and S. Zhang, A traction force threshold signifies metastatic phenotypic change in multicellular epithelia, Soft Matter, 15: 7203-7210, 2019.

2010-2018 (Prior NTU)

C. Huang, Z. Wang, D. Quinn, S. Suresh and K. J. Hsia, Differential Growth and Shape Formation in Plant Organs, Proceedings of the National Academy of Sciences of the United States of America 114: 12359-12364, 2018.
A. M. Esfahani, W. Zhao, J. Y. Chen, C. Huang, N. Xi, J. Xi and R. Yang, On the Measurement of Energy Dissipation of Adherent Cells with the Quartz Microbalance with Dissipation Monitoring, Analytical Chemistry 90: 10340-10349, 2018.
Q. Wei, C. Huang, Y. Zhang, T. Zhao, P. Zhao, P. J. Butler and S. Zhang, Mechanotargeting: Mechanics-Dependent Cellular Uptake of Nanoparticles, Advanced Materials 30: 1707464, 2018.
C. Huang, D. Quinn, S. Suresh and K. J. Hsia, Controlled molecular self-assembly of complex three-dimensional structures in soft materials, Proceedings of the National Academy of Sciences of the United States of America 115: 70-74, 2018.
R. Yang, V. Lemaitre, C. Huang, A. Haddadi, R. McNaughton and H. D. Espinosa, Monoclonal cell line generation via high throughput single cell electroporation, Small 14: 1702495, 2018.
C. Huang, D. Quinn, Y. Sadovsky, S. Suresh and K. J. Hsia, Formation and size analysis of self-assembled vesicles, Proceedings of the National Academy of Sciences of the United States of America 114: 2910-2915, 2017.
J. A. Broussard, R. Yang, C. Huang, S. S. P. Nathamgari, A. M. Beese, L. M. Godsel, M. H. Hegazy, S. Lee, F. Zhou, N. J. Sniadecki, K. J. Green and H. D. Espinosa, The desmoplakin-intermediate filament linkage regulates cell mechanics, Molecular Biology of the Cell 28: 3156-3164, 2017.
H. Hu, C. Huang, X.H. Liu and K.J. Hsia, Thin film wrinkling by strain mismatch on 3D surfaces, Extreme Mechanics Letters 8: 107-113, 2016.
M. Dearnley, C. Trang, Y. Zhang, O. Looker, C. Huang, N. Klonis, J. Yeoman, S. Kenny, M. Arora, J. M. Osborne, R. Chandramohanadas, S. Zhang, M. W. Dixon, and L. Tilly, Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages, Proceedings of the National Academy of Sciences of the United States of America 113: 4800-4805, 2016.
C. Huang*, T. Ozdemir*, L. Xu, P. J. Butler, C. Siedlecki, J. Brown and S. Zhang, The role of substrate topography on the cellular uptake of nanoparticles, Journal of Biomedical Materials Research: Part B – Applied Biomaterials 104B: 488-495, 2016 (*equal contribution).
Y. Zhang, C. Huang, S. Kim, M. Golkaram, M. W. Dixon, L. Tilly, J. Li, S. Zhang and S. Suresh, Multiple stiffening effects of nano-scale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite, Proceedings of the National Academy of Sciences of the United States of America 112: 6068-6073, 2015.
H. Zhang, Q. Ji, C. Huang, S. Zhang, B. Yuan, K. Yang and Y. Ma, Cooperative Transmembrane Penetration of Nanoparticles, Scientific Reports 5: 10525, 2015.
C. Huang, Y. Zhang, H. Yuan, H. Gao and S. Zhang, Role of Nanoparticle Geometry in Endocytosis: Laying Down to Stand Up, Nano Letters 13: 4546-4550, 2013.
C. Huang, P. J. Butler, S. Tong, H. S. Muddana, G. Bao and S. Zhang, Substrate Stiffness Regulates Cellular Uptake of Nanoparticles, Nano Letters 13: 1611-1615, 2013.
H. Yuan, C. Huang, and S. Zhang, Membrane-Mediated Inter-Domain Interactions, BioNanoScience 1: 97-102, 2011.
C. Huang, H. Yuan, and S. Zhang, Coupled Vesicle Morphogenesis and Domain Organization, Applied Physics Letters 98: 043702, 2011.
H. Yuan, C. Huang, and S. Zhang, Virus-Inspired Design Principles of Nanoparticle-Based Bioagents, PLoS ONE 5: e13495, 2010.
H. Yuan, C. Huang, and S. Zhang, Dynamic shape transformations of fluid vesicles, Soft Matter 6: 4571-4579, 2010.
H. Yuan, ,C. Huang, J. Li, G. Lykotrafitis, and S. Zhang, One-particle-thick solvent-free coarse-grained model for biological and biomimetic fluid membranes, Physical Review E 82: 011905, 2010.

C.J. Huang Research Group

Biomechanics & Bio-inspired Engineering

Journal Publications

2024

2023

2022

2021

2020

2019

2010-2018 (Prior NTU)