Qingqing Miao, Chen Xie, Xu Zhen, Yan Lyu, Hongwei Duan, Xiaogang Liu, Jesse V. Jokerst, Kanyi Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nature Biotechnology, 2017, 35, 1102–1110. [Highlighted by Nature Methods]

Qingqing Miao, Chen Xie, Xu Zhen, Yan Lyu, Hongwei Duan, Xiaogang Liu, Jesse V. Jokerst, Kanyi Pu. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nature Biotechnology, 2017, 35, 1102–1110.

Svetlana Chechetka, Yue Yu, Xu Zhen, Manojit Pramanik, Kanyi Pu, Eijiro Miyako. Light-driven liquid metal nanotransformers for biomedical theranostics. Nature Communications, 2017, 8, 15432.

Yan Lyu, Dong Cui, He Sun, Yansong Miao, Hongwei Duan, Kanyi Pu. Dendronized semiconducting polymer as photothermal nanocarrier for remote activation of gene expression. Angewandte Chemie International Edition, 2017, 56, 9155-9159.

Chen Xie, Xu Zhen, Yan Lyu, Kanyi Pu. Nanoparticle regrowth enhances photoacoustic signals of semiconducting macromolecular probe for in vivo imaging. Advanced Materials, 2017, 29, 1703693.

Xu Zhen, Ye Tao, Zhongfu An, Peng Chen, Chenjie Xu, Runfeng Chen, Wei Huang, Kanyi Pu. Ultralong phosphorescence of water-soluble organic nanoparticles for in vivo afterglow imaging. Advanced Materials, 2017, 29, 1606665.

Jianjian Zhang, Xu Zhen, Paul Kumar Upputuri, Manojit Pramanik, Peng Chen, Kanyi Pu. Activatable photoacoustic nanoprobes for in vivo ratiometric imaging of peroxynitrite. Advanced Materials, 2017, 29, 1604764. [Cover]

Yuyan Jiang, Paul Upputuri, Chen Xie, Yan Lyu, Lulu Zhang, Qihua Xiong, Manojit Pramanik, Kanyi Pu. Broadband absorbing semiconducting polymer nanoparticles for photoacoustic imaging in second near-infrared window. Nano Letters, 2017, 17, 4964–4969.

Houjuan Zhu, Yuan Fang, Qingqing Miao, Xiaoying Qi, Dan Ding, Peng Chen, Kanyi Pu. Regulating near-infrared photodynamic properties of semiconducting polymer nanotheranostics for optimized cancer therapy. ACS Nano, 2017, 11, 8998–9009.

Chao Yin, Xu Zhen, Quli Fan, Wei Huang, Kanyi Pu. Degradable semiconducting oligomer amphiphile for ratiometric photoacoustic imaging of hypochlorite. ACS Nano, 2017, 11, 4174–4182.

Yan Lyu, Xu Zhen, Yansong Miao, Kanyi Pu. Reactivity-based semiconducting polymer nanoprobes for photoacoustic imaging of protein sulfenic acids. ACS Nano, 2017, 11, 358–367.

Chao Yin, Houjuan Zhu, Chen Xie, Lei Zhang, Peng Chen, Quli Fan, Wei Huang, Kanyi Pu. Organic nanoprobe cocktails for multilocal and multicolor fluorescence imaging of reactive oxygen species. Advanced Functional Materials, 2017, 27, 1700493.

Chen Xie, Xu Zhen, Qunli Lei, Ran Ni, Kanyi Pu. Self-assembly of semiconducting polymer amphiphiles for in vivo photoacoustic imaging. Advanced Functional Materials, 2017, 27, 1605397. [Cover]

Yuyan Jiang, Dong Cui, Yuan Fang, Xu Zhen, Paul Kumar Upputuri, Manojit Pramanik, Dan Ding, Kanyi Pu. Amphiphilic semiconducting polymer as multifunctional nanocarrier for fluorescence/photoacoustic imaging guided chemo-photothermal therapy. Biomaterials, 2017, 145, 168–177.

Xu Zhen, Xiaohua Feng, Chen Xie, Yuanjin Zheng, Kanyi Pu. Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging. Biomaterials, 2017, 127, 97–106.

Chen Xie, Paul Kumar Upputuri, Xu Zhen, Manojit Pramanik, Kanyi Pu. Self-quenched semiconducting polymer nanoparticles for amplified in vivo photoacoustic imaging. Biomaterials, 2017, 119, 1–8

Yuyan Jiang, Kanyi Pu. Advanced photoacoustic imaging applications of near-infrared absorbing organic nanoparticles. Small, 2017, 13, 1700710. [Review]

Jingqi Tian, Houjuan Zhu, Jie Chen, Xinting Zheng, Hongwei Duan, Kanyi Pu, Peng Chen. Cobalt phosphide double-shelled nanocages: broadband light-harvesting nanostructures for efficient photothermal therapy and self-powered photoelectrochemical biosensing. Small, 2017, 13, 1700798.

Houjuan Zhu, Zhuangchai Lai, Yuan Fang, Xu Zhen, Chaoliang Tan, Xiaoying Qi, Dan Ding, Peng Chen, Hua Zhang, Kanyi Pu. Ternary chalcogenide nanosheets with ultrahigh photothermal conversion efficiency for photoacoustic theranostics. Small, 2017, 13, 1604139.

Chao Yin, Xu Zhen, Hui Zhao, Yufu Tang, Yu Ji, Yan Lyu, Quli Fan, Wei Huang, Kanyi Pu. Amphiphilic semiconducting oligomer for near-infrared photoacoustic and fluorescence imaging. ACS Applied Materials & Interfaces, 2017, 9, 12332–12339.

Yan Lyu, Kanyi Pu. Recent advances of activatable molecular probes based on semiconducting polymer nanoparticles in sensing and imaging. Advanced Science, 2017, 1600481. [Review]

Dong Cui, Chen Xie, Kanyi Pu. Development of semiconducting polymer nanoparticles for photoacoustic imaging. Macromolecular Rapid Communications, 2017, 38, 1700125. (Invited Feature Article)

Dong Cui, Chen Xie, Yan Lyu, Zhen Xu, Kanyi Pu. Near-infrared absorbing amphiphilic semiconducting polymers for photoacoustic imaging. Journal of Materials Chemistry B, 2017, 5, 4406–4409. (Invited, Emerging Investigators Issue)

Kenath Priyanka Prasad, Aung Than, Nan Li, Mahasin Alam SK, Hongwei Duan, Kanyi Pu, Xinting Zheng, Peng Chen. Thiophene-derived polymer dots for imaging endocytic compartments in live cells and broad-spectrum bacterial killing. Materials Chemistry Frontiers, 2017, 1, 152–157.

Yan Lyu, Chen Xie, Svetlana A. Chechetka, Eijiro Miyako, Kanyi Pu. Semiconducting polymer nanobioconjugates for targeted photothermal activation of neurons. Journal of the American Chemical Society, 2016, 138, 9049–9052.

Qingqing Miao, Yan Lyu, Dan Ding, Kanyi Pu. Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH. Advanced Materials, 2016, 28, 3662–3668.

Nan Li, Aung Than, Chencheng Sun, Jingqi Tian, Jie Chen, Kanyi Pu, Xiaochen Dong, Peng Chen. Monitoring dynamic cellular redox homeostasis using fluorescence-switchable graphene quantum dots. ACS Nano, 2016, 10, 11475–11482.

Xu Zhen, Chengwu Zhang, Chen Xie, Qingqing Miao, Kah-Leong Lim, Kanyi Pu. Intraparticle energy level alignment of semiconducting polymer nanoparticles to amplify chemiluminescence for ultrasensitive in vivo imaging of reactive oxygen species. ACS Nano, 2016, 10, 6400–6409.

Yan Lyu, Yuan Fang, Qingqing Miao, Xu Zhen, Dan Ding, Kanyi Pu. Intraparticle molecular orbital engineering of semiconducting polymer nanoparticles as amplified theranostics for in vivo photoacoustic imaging and photothermal therapy. ACS Nano, 2016, 10, 4472–4481.

Houjuan Zhu, Yuan Fang, Xu Zhen, Na Wei, Yu Gao, Kathy Qian Luo, Chenjie Xu, Hongwei Duan, Dan Ding, Peng Chen, Kanyi Pu. Multilayered semiconducting polymer nanoparticles with enhanced NIR fluorescence for molecular imaging in cells, zebrafish and mice. Chemical Science, 2016, 7, 5118–5125.

Kanyi Pu, Niladri Chattopadhyay, Jianghong Rao. Recent advance of semiconducting polymer nanoparticles in in vivo molecular imaging. Journal of Controlled Release, 2016, 240, 312–322

Qingqing Miao, Kanyi Pu. Emerging designs of activatable photoacoustic probes for molecular imaging. Bioconjugate Chemistry, 2016, 27, 2808–2823. [Review]

Praveen D. Chowdary, Daphne L. Che, Luke Kaplan, Ou Chen, Kanyi Pu, Moungi Bawendi, Bianxiao Cui, Nanoparticle-assisted optical tethering of endosomes reveals the cooperative function of dyneins in retrograde axonal transport, Sci Rep. 2015; 5: 18059.

Pu K, Mei J, Jokerst JV, Hong G, Antaris AL, Chattopadhyay N, Shuhendler AJ, Kurosawa T, Zhou Y, Gambhir SS, Z Bao, J Rao, Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for In vivo photoacoustic imaging. Adv. Mater. 2015, 27, 5184–5190.

Palner M, Pu K, Shao S, Jeon J, Rao J. Semiconducting polymer nanoparticles with persistent near-Infrared luminescence show potential for In vivo optical imaging. Angew. Chem. Int. Ed. 2015, 127, 11639–11642.

Wang TZ, Choe JW, Pu K, Devulapally R, Bachawal S, Machtaler S, Chowdhury SM, Luong R, Tian L, Khuri- Yakub B, Rao J, Paulmurugan R, Willmann JK. Image-guided ultrasound and microbubble facilitated delivery of therapeutic carriers into tumors: effects of acoustic and microbubble parameters. J. Control. Release, 2015, 203, 99.

Shuhendler AJ, Pu K (equal contribution), Cui L, Uetrecth JP, Rao J, Real-Time imaging of oxidative and nitrosative stress with in the liver of live animals for drug-toxicity testing. Nature Biotechnology, 2014, 32, 373–380. [Highlighted by Chemistry & Biology from Cell Press; Chemistryword from RSC; SciBX from the makers of BioCentury and Nature; CORANTE]

Pu K, Shuhendler AJ, Jokerst JV, Mei J, Gambhir SS, Bao Z, Rao J. Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice. Nature Nanotechnology, 2014, 9, 233–239. [Highlighted by CEN UCSD; NanotechWeb; Greenfluorescentblog; Phys.org; USA News]

Pu K, Shuhendler AJ, Valta MP, Cui L, Saar M, Peehl DM, Rao J. Phosphorylcholine-coated semiconducting polymer nanoparticles as rapid and efficient labeling agents for in vivo cell tracking. Adv. Healthcare Mater. 2014, 3, 1292.

Pu K, Shuhendler AJ, Rao J. Semiconducting polymer nanoprobe for real-time in vivo imaging of reactive oxygen and nitrogen species. Angew. Chem. Int. Ed. 2013, 52, 10325–10329.

Zhang M, Gao B, Pu K, Yao Y, Inyang M. Graphene-mediated self-assembly of zeolite-based microcapsules. Chem. Eng. J. 2013, 223, 556–562.

Ding D, Wang G, Liu JZ, Li K, Pu K, Hu Y, Ng JCY, Tang BZ, Liu B. Hyperbranched conjugated polyelectrolyte for dual-modality fluorescence and magnetic resonance cancer imaging. Small 2012,8,3523-3530.

Li k, Ding D, Huo D, Pu K, Thao NNP, Hu Y, Li Z, Liu B. Conjugated polymer based nanoparticle as a dual-modal probe for targeted in-vivo fluorescence and magnetic resonance imaging. Adv. Funct. Mater. 2012, 22, 3107–3115.

Geng JL, Li Kai, Pu K, Ding D, Liu B. Conjugated polymer and gold nanoparticle co-loaded PLGA nanocomposites with eccentric internal nanostructure for dual-modal targeted cellular imaging. Small 2012, 8, 2421–2409

Wang G, Zhang XH, Geng JL, Li K, Ding D, Pu K, Lai YH, Liu B. Glycosylated star-shaped conjugated oligomer for targeted two-photon fluorescence imaging. Chem. Eur. J. 2012, 18, 9705–9713

Wang LH, Pu K (equal contribution), Jing L, Qi XY, Li H, Zhang H, Fan CH, B. Liu, A graphene/conjugated oligomer hybrid sensor for light-up sensing of lectins and bacteria. Adv. Mater. 2011,23, 4386–4391

Pu K, Liu B. Florescent conjugated polyelectrolytes for bioimaging. Adv. Funct. Mater. 2011, 21,3408–3423.[Feature Article, Frontispiece]

Duarte A, Pu K (equal contribution) Liu B, Bazan GC. Recent advance in conjugated polyelectrolytes for emerging optoelectronic applications. Chem. Mater. 2011, 23, 6736–6741. [Review] [Most read articles in September 2010]

Pu K, Shi JB, Cai LP, Li K, Liu B. Affibody-attached hyperbranched conjugated polyelectrolyte for targeted fluorescence imaging of HER2-positive cancer cell. Biomacromolecules 2011, 12, 2966–2974. [Highlighted by ACS as Noteworthy Chemistry, Sept. 12, 2011]

Pu K, Luo ZT, Li K, Xie JP, Liu B. Energy transfer between gold nanocluster and conjugated oligoelectrolyte substituted POSS for multicolor intracellular detection of mercury ion. J. Phys. Chem. C 2011, 115, 13069–13075.

Wang YF, Zhan RY, Li TH, Pu K, Wang YY, Tan YC, Liu B. Visual detection of single nucleotide polymorphism using cationic conjugated polyelectrolyte and rolling circle amplification. Langmuir 2011, 28, 889–895.

Wang G, Pu K, Li, K, Zhang XH, Cai LP, Ding D, Lai YH, Liu B. Star-shaped glycosylated conjugated oligomer for live cell two-photon imaging. Chem. Mater. 2011, 23, 4428–4434.

Cai LP, Zhan RY, Pu K, Qi XY, Zhang H, Liu B. Star-shaped conjugated oligoelectrolyte with graphene oxide for light-up Visual detection of heparin. Anal. Chem. 2011, 83, 7849–7855.

Mi Y, Li K, Liu YT, Pu K, Liu B, Feng SS. POSS-containing conjugated oligomers formulated in silica nanoparticles of iron oxides shell and herceptin surface functionalization for circulating tumor cells sorting and detection. Biomaterials 2011, 32, 8226–8233.

Ding D, Pu K, Li K, Liu B. Conjugated oligoelectrolyte-polyhedral oligomeric silsesquioxane loaded pH-responsive nanoparticles for targeted fluorescence imaging of cancer cell nucleus. Chem. Commun. 2011, 47, 9837–9839.

Li K, Pu K, Cai LP, Liu B. Phalloidin-functionalized hyperbranched conjugated polyelectrolyte for filamentous actin imaging in living Hela cells. Chem. Mater. 2011, 23, 2113–2119.

Ding D, Li K, Zhu ZS, Pu K, Hu Y, Jiang XQ, Liu, B. Conjugated polyelectrolyte-cisplatin complex nanoparticles for simultaneous in-vivo imaging and drug tracking. Nanoscale 2011, 3, 1997–2002. [Cover]

Pu K, Li K, Zhang XH, Liu B. Conjugated oligoelectrolyte harnessed POSS as light-up hybrid unimolecular nanodots for two-photon fluorescence imaging of cellular nucleus. Adv. Mater. 2010, 22, 4186–4189. [Cover] [Highlighted by Phys.Org, Feb. 24, 2011]

Pu K, Li K, Liu B. Cationic oligofluorene substituted POSS as light-harvesting unimolecular nanoparticle for fluorescence amplification in cellular imaging. Adv. Mater. 2010, 22, 643–646.

Pu K, Li K, Liu B. A molecular brush approach to enhance quantum yield and suppress nonspecific interactions of conjugated polyelectrolyte for far-red/near-infrared fluorescence targeted cell imaging. Adv. Funct. Mater. 2010, 20, 2770–2777. [Frontispiece]

Pu K, Zhan RY, Liu B. Conjugated polyelectrolyte blend as perturbable energy donor-acceptor assembly for multicolor fluorescence responses to proteins. Chem. Commun. 2010, 46, 1470–1472.

Pu K, Shi JB, Wang LH, Cai LP, Wang G, Liu B. Mannose-substituted conjugated polyelectrolyte and oligomer as an intelligent energy transfer pair for visual detection of concanavalin A. Macromolecules 2010, 43, 9690–9697.

Pu K, Liu B. Fluorescence turn-on responses of anionic and cationic conjugated polymers toward proteins: effect of electrostatic and hydrophobic interactions. J. Phys. Chem. B 2010, 114, 3077–3084. [Cover]

Qi XY, Pu K (equal contribution), Li H, Zhou XZ, Wu SX, Fan QL, Liu B, Huang W, Zhang H. Amphiphilic graphene composites. Angew. Chem. Int. Ed. 2010, 49, 9426–9429. [Highlighted by John Wiley as Carbon]

Li K, Liu Y, Pu K, Feng SS, Zhan R, Liu B. Polyhedral oligomeric silsesquioxanes-containing conjugated polymer loaded PLGA nanoparticles with trastuzumab (herceptin) functionalization for HER2-positive cancer cell detection. Adv. Funct. Mater. 2010, 21, 287–294. [Cover]

Wang C, Zhan R, Pu K, Liu B. Conjugated polymer amplified bead array for DNA detection with zeptomole sensitivity and single nucleotide polymorphism selectivity. Adv. Funct. Mater. 2010, 20, 2597–2604.

Qi XY, Pu K, Zhou XZ, Li H, Liu B, Boey F, Huang W, Zhang H. Conjugated polyelectrolyte functionalized reduced graphene oxide with excellent solubility and stability in polar solvents. Small 2010, 6, 663–669.

Shi JB, Cai LP, Pu K, Liu B. Synthesis and characterization of water-soluble conjugated glycopolymer for fluorescent sensing of concanavalin A. Chem. Asian. J. 2010, 5, 301–308.

Wang YY, Pu K, Liu B. Anionic conjugated polymer with aptamer-functionalized silica nanoparticle for label-free naked-eye detection of lysozyme in mixed sample. Langmuir 2010, 26, 10025–10030.

Pu K, Liu B. Intercalating dye harnessed cationic conjugated polymer for real-time naked-eye recognition of double-stranded DNA in serum. Adv. Funct. Mater. 2009, 19, 1371–1378. [Cover]

Pu K, Liu B. Conjugated polyelectrolytes as light-up macromolecular probes for heparin sensing. Adv. Funct. Mater. 2009, 19, 277–284. [Highlighted by ACS as Noteworthy Chemistry, March 2, 2009]

Pu K, Li K, Shi, JB, Liu B. Fluorescent single-molecular core-shell nanospheres of hyperbranched conjugated polyelectrolyte for live-cell imaging. Chem. Mater. 2009, 21, 3816–3822.

Pu K, Liu B. Optimizing the cationic conjugated polymer-sensitized fluorescent signal of dye labeled oligonucleotide for biosensor applications. Biosens. Bioelectron. 2009, 24, 1067–1073. [Review]

Pu K, Cai LP, Liu B. Design and synthesis of charge-transfer-based conjugated polyelectrolytes as multicolor light up probes, Macromolecules 2009,42, 5933–5940.

Pu K, Zhan R, Liu B. Surfactant effect on energy transfer between cationic conjugated polymer and dye-labeled oligonucleotide. Macromol. Symp. 2009,279, 48–51.

Li K, Pan J, Feng SS, Wu AW, Pu K, Liu YT, Liu B. Generic strategy of preparing fluorescent conjugated-polymer-loaded poly(DL-lactide-co-glycolide) nanoparticles for targeted cell imaging. Adv. Funct. Mater. 2009, 19, 3535–3542. [Frontispiece]

Dishair SK, Pu K, Liu B. Combinatorial energy transfer between an end-capped conjugated polyelectrolyte and chromophore-labeled PNA for strand-specific DNA detection.Macromol. Rapid Commun. 2009, 30, 1645–1650. [Cover]

Shi JB, Pu K, Zhan RY, Liu B. Cationic conjugated polymer/heparin interpolyelectrolyte complexes for heparin quantification. Macromol. Chem. Phys. 2009, 210, 1195–1200.

Chen Y, Pu K, Fan QL, Qi XY, Huang YQ, Lu XM, Huang W. Water-soluble anionic conjugated polymers for metal ion sensing: effect of interchain aggregation. J. Polym. Sci. Polym. Chem. 2009, 47, 3776–3787.

Wang HY, Pu K, Shu H, Feng L, Bo P, Wei W. Alternating copolymers based on perylene bisimide and OPE units: synthesis, characterization, and photoinduced energy and electron transfer processes of a new class of donor–acceptor systems, React. Funct. Polym. 2009, 69, 117–123.

Pu K, Fang Z, Liu B. Effect of charge density on energy-transfer properties of cationic conjugated polymers. Adv. Funct. Mater. 2008, 18, 1321–1328. [VIP article] [Highlighted by Materials View in John Wiley and Noteworthy Chemistry in ACS]

Pu K, Liu B. A multicolor cationic conjugated polymer for naked-eye detection and quantification of heparin. Macromolecules 2008, 41, 6636–6640.

Pu K, Pan SYH, Liu B. Optimization of interactions between a cationic conjugated polymer and chromophore-labeled DNA for optical amplification of fluorescent sensors. J. Phys. Chem. B 2008, 112, 9295–9300.

Fang Z, Pu K, Liu B. Asymmetric fluorescence quenching of dual-emissive porphyrin-containing conjugated polyelectrolytes for naked-eye mercury ion detection. Macromolecules 2008, 41, 8380–8387.

Pu K, Qi XY, Lu XM, Yang LL, Li TC, Fan QL, Liu B, Chan HSO, Wang C, Huang W. Supramolecular regulated photophysical properties of oligo(p-phenyleneethynylene)-base rod-coil block copolymers: effect of molecular architecture. Chem. Eur. J. 2008, 14, 1205–1215.

Pu K, Qi XY, Lu XM, Fan QL, Huang W. ATRP synthesis of grafted poly(p-phenyleneethynylene) with energy donor-acceptor architecture via atom transfer radical polymerization: toward nonaggregating and hole-facilitating light-emitting materials. J. Polym. Sci. Polym. Chem. 2007, 45, 3776–3787.

Deng Y, Liu SJ, Fan QL, Fang C, Zhu R, Pu K, Yuwen LH, Huang W. Synthesis and characterization of polymers containing charged iridium complexes andcabarzole units. Synth. Met. 2007, 157, 813–822.

Qi XY, Pu K, Fang C, Wen GA, Zhang H, Boey FYC, Fan QL, Wang LH, Huang W. Semiconductor nanocomposites of emissive flexible random copolymers and CdTe nanocrystals: preparation, characterization, and optoelectronic properties. Macromol. Chem. Phys. 2007, 208, 2007–2017.

Pu K, Zhang B, Ma Z, Wang P, Qi XY, Chen RF, Wang LH, Fan QL, Huang W. Synthesis, morphology and photophysics of novel hybrid organic-inorganic polyhedral oligomeric silsesquioxane-tethered poly(fluorenyleneethynylene)s. Polymer 2006, 47, 1970–1978.

Pu K, Fan QL, Wang LH, Huang W. Advances in POSS-containing polymers. Prog. Chem. 2006, 18, 609–615. [Review]

Chen RF, Fan QL, Liu SJ, Zhu R, Pu K, Huang W. Fluorene and silafluorene conjugated copolymer: A new blue light-emitting polymer. Synth. Met. 2006, 156, 1161–1167.