Particle Technology Lab
Publications
Book Chapter
- W.S. Cheow and K. Hadinoto, "Antibiotic Polymeric Nanoparticles for Biofilm-Associated Infection Therapy". In G. Donelli (Ed.), Microbial Biofilms - Methods and Protocols, 2014. Humana Press. Link.
Journal papers
2018
- T.T. Tran,C. Vidaillac, H. Yu, V. Yong, D. Roizman, R. Chandrasekaran, A.Y.H. Lim, T.B. Low. G.L. Tan, J.A. Abisheganaden, M. Koh, J. Teo, S.H. Chotirmall, K. Hadinoto*, ”A new therapeutic avenue for bronchiectasis: Dry powder inhaler of ciprofloxacin nanoplex exhibits superior ex vivo mucus permeability and antibacterial efficacy to its native ciprofloxacin counterpart“, Int. J. Pharmaceutics , 547, 368-376,2018.
- L.M. Lim,T.T. Tran,J.J.L. Wong,D. Wang,W.S.Cheow, K. Hadinoto*, ”Amorphous ternary nanoparticle complex of curcumin-chitosan-hypromellose exhibiting built-in solubility enhancement and physical stability of curcumin“, Colloids Surf. B , 167, 483-491,2018.
- J.J.L. Wong, H. Yu, L.M. Lim, K. Hadinoto*, ”A trade-off between solubility enhancement and physical stability upon simultaneous amorphization and nanonisation of curcumin in comparison to amorphization alone“, Eur. J. Pharm. Sci. , 114, 356-363,2018.
- K.N. Khaqqi, J.J. Sikorski, K. Hadinoto*,M. Kraft, ”Incorporating seller/buyer reputation-based system in blockchain-enabled emission trading application“, Applied Energy ,209, 8-19, 2018.
- J.J.L. Wong, H. Yu, K. Hadinoto*, ”Examine practical feasibility of amorphous curcumin-chitosan nanoparticle complex as solubility enhancement strategy of curcumin: Scaled-up production, dry powder transformation, and long-term physical stability“, Colloids Surf. A ,537, 36-43, 2018.
- H. Yu, M.H. Nguyen, K. Hadinoto*, ”Effects of chitosan molecular weight on the physical and dissolution characteristics of amorphous curcumin-chitosan nanoparticle complex“, Drug Dev. Ind. Pharm. ,44, 82-88, 2018.
2017
- L.M. Lim, T.T. Tran, W.S. Cheow, K. Hadinoto*, ”Re-evaluating the presumed superiority of amorphous nanoparticles over amorphous microscale solid dispersion in solubility enhancement of poorly soluble drugs“, Eur. J. Pharm. Sci. , 109, 455-463, 2017.
- M.H. Nguyen, N.D. Pham, B.X. Dong, T.H.N. Nguyen, C.B. Bui, K. Hadinoto*, ”Radioprotection activités of curcumin-encapsulated liposomes against genotoxicity caused by Gamma-Cobalt-60 irradiation in human blood cells“, Int. J. Radiation Biol. , 93(11), 1267-1273, 2017.
- H. Yu, K. Hadinoto*, ”Impact of dextran sulphate’s chain length on the characteristics of its self-assembled colloidal complex formed with amphiphilic small-molecule drug“, Int. J. Bio. Macromolecules. , 103, 493-500, 2017.
- H. Yu, M.H. Nguyen, W.S. Cheow, K. Hadinoto*, ”A new bioavailability enhancement strategy of curcumin via self-assembly nano-complexation of curcumin and bovine serum albumin“, Mat. Sci. Engr. C, 75, 25-33, 2017.
- B.X. Dong, K. Hadinoto*, ”Amorphous nanoparticle complex of perphenazine and dextran sulphate as a new solubility enhancement strategy of antipsychotic perphenazine“, Drug Dev. Ind. Pharm. , 43(6), 996-1002, 2017.
- B.X. Dong, K. Hadinoto*, ”Direct comparison between millifluidics and bulk-mixing platform in the synthesis of amorphous drug-polysaccharide nanoparticle complex“, Int. J. Pharm. , 523, 42-51, 2017.
- T.T. Tran, K. Hadinoto*, ”A new solubility enhancement strategy of capsaicin in the form of high-payload submicron capsaicin-chitosan colloidal complex“, Colloids Surf. A, 520, 62-71, 2017.
- T.T. Tran, M.H. Nguyen, Y.Z. Tan, J.W. Chew, S.A. Khan, K. Hadinoto*, ”Millifluidic synthesis of amorphous drug-polysaccharide nanoparticle complex with tunable size intended for supersaturating drug delivery applications“, Eur. J. Pharm. Biopharm. , 112, 196-203, 2017.
- Q.L.Lei, K. Hadinoto*, R. Ni*, ”Complexation of polyelectrolytes with hydrophobic drug molecules in salt-free solution: Theory and Simulations“, Langmuir , 33(15), 3900-3909, 2017.
- Q.L.Lei, K. Hadinoto, R. Ni*, ”Role of local assembly in the hierarchical crystallisation of associating colloidal hard hemispheres“, Phys. Rev. Mat. , 1(5), 052601, 2017.
2016
- H. Yu, T.T. Tran, J. Teo, and K. Hadinoto*, "Dry powder aerosols of curcumin-chitosan nanoparticle complex prepared by spray freeze drying and their antimicrobial efficacy against common respiratory bacterial pathogens", Colloids Surf. A , 504, 34-42, 2016.
- M.H. Nguyen, H. Yu, B.X. Dong, and K. Hadinoto*, "A supersaturating delivery system of silibinin exhibiting high payload achieved by amorphous nano-complexation with chitosan", Eur. J. Pharm. Sci. , 89, 163-171, 2016. Link.
- M.H. Nguyen, T.T. Tran, and K. Hadinoto*, "Controlling the burst release of amorphous drug-polysaccharide nanoparticle complex via crosslinking of the polysaccharide chains", Eur. J. Pharm. Biopharm. , 104, 156-163, 2016 Link.
- H. Yu, J. Teo, J.W. Chew and K. Hadinoto*, "Dry powder inhaler formulation of high-payload antibiotic nanoparticle complex intended for bronchiectasis therapy: spray drying versus spray freeze drying preparation", Int. J. Pharmaceutics , 499, 38-46, 2016. Link.
- A. Anantharaman, A. Cahyadi, K. Hadinoto, J.W. Chew, "Impact of particle diameter, density, and sphericity on minimum pick-up velocity of binary mixtures in gas-solid pneumatic conveying", Powder Technol. , 297, 311-319, 2016. Link.
- W.S. Cheow, T.Y. Kiew and K. Hadinoto*, "Effect of adding resistant and waxy starches on cell density and survival of encapsulated biofilm of Lactobacillus rhamnosus GG probiotics", LWT Food Sci. and Technol. 69, 497-505, 2016. Link.
2015
- W.S. Cheow, T.Y. Kiew, and K. Hadinoto*, "Combining inkjet printing and amorphous nanonization to prepare personalized dosage forms of poorly-soluble drugs", Eur. J. Pharm. Biopharm. , 96, 314-321, 2015. Link.
- M.H. Nguyen, H. Yu, T.Y. Kiew, and K. Hadinoto*, "Cost-effective alternative to nano-encapsulation: Amorphous curcumin-chitosan nanoparticle complex exhibiting high payload and supersaturation generation", Eur. J. Pharm. Biopharm. , 96, 1-10, 2015. Link.
- A. Anantharaman, X. Wu, K. Hadinoto, J.W. Chew, "Impact of continuous particle size distribution width and particle sphericity on minimum pick-up velocity in gas-solid pneumatic conveying", Chem. Engr. Sci, 130 (7), 92-100, 2015. Link.
- H. Yu and K. Hadinoto*, "Mitigating the adverse effect of spray drying on the supersaturation generation capability of amorphous nanopharmaceutical powders", Powder Technol. , 277, 97-104, 2015. Link.
- M. Kutscher, W.S. Cheow, V. Werner, U. Lorentz, K. Ohlsen, L. Meinel, K. Hadinoto, O. Germershaus, "Influence of salt type and ionic strength on the self-asembling of polyelectrolyte-drug nanoplexes", Int. J. Pharmaceutics, 486, 21-29, 2015. Link.
- T.Y. Kiew, W.S. Cheow, and K. Hadinoto*, "Preserving the supersaturation generation capability of amorphous drug-polysaccharide nanoparticle complex after freeze drying", Int. J. Pharmaceutics, 484, 115-123, 2015. Link.
- K.Y. Lim, R.Y. Chua, B. Ho, P.A. Tambyah, K. Hadinoto*, S.S.J. Leong, "Development of a catheter functionalized by a polyphodamine-peptide coating with antimicrobial and anti-biofilm properties", Acta Biomater.,15,127-138,2015. Link.
- W.S. Cheow, T.Y. Kiew, and K. Hadinoto*, "Amorphous nanodrugs prepared by complexation with polysaccharides: Carrageenan versus Dextran Sulfate", Carbohydr. Polym. 117, 549-558, 2015. Link.
2014
- K. Hadinoto* and Y. Yang, "Continuous and sustainable granulation of nanopharmaceuticals via spray coagulation encapsulation in alginate", Int. J. Pharmaceutics, 473 (1-2), 644-652, 2014. Link.
- T.Y. Kiew, W.S. Cheow, and K. Hadinoto*, "Importance of biofilm age and growth medium on the viability of probiotic capsules containing Lactobacillus rhamnosus biofilm", LWT Food Sci. and Technol. 59(2), 956-963, 2014. Link.
- W.S. Cheow, T.Y. Kiew, Y. Yang and K. Hadinoto*, "Amorphization strategy affects the stability and supersaturation profile of amorphous drug nanoparticles", Mol. Pharmaceut. 11(5), 1611-1620, 2014. Link.
- K. Hadinoto* and W.S. Cheow, "Nano-antibiotics in chronic lung infection therapy against Pseudomonas aeruginosa", Colloid Surface B. 116, 772-785, 2014. Link.
- W.S. Cheow, T.Y. Kiew and K. Hadinoto*, "Controlled release of Lactobacillus rhamnosus biofilm probiotics from alginate-locust bean gum microcapsules", Carbohydr. Polym, 103,587-595, 2014. Link.
2013
- W.S. Cheow and K. Hadinoto*, "Biofilm-Like Lactobacillus rhamnosus Probiotics Encapsulated in Alginate and Carrageenan Microcapsules Exhibiting Enhanced Thermotolerance and Freeze Drying Resistance", Biomacromolecules, 19,3214-3222, 2013. Link.
- K. Hadinoto*, A. Sundaresan, and W.S. Cheow, "Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review", Eur. J. Pharm. Biopharm, 85,427-443, 2013. Link.
- Y. Yang and K. Hadinoto*, "A Highly Sustainable and Versatile Granulation Method of Nanodrugs via Their Electrostatic Adsorption onto Chitosan Microparticles as the Granulation Substrates ", Int. J. Pharmaceutics, 452,402-411, 2013. Link.
- W.S. Cheow, R. Xu, and K. Hadinoto*, "Towards Sustainability: New Approaches to Nano-Drug Preparation", Curr. Pharm. Design, 19,6229-6245, 2013. Link.
- K. Kho and K. Hadinoto*, "Dry powder inhaler delivery of amorphous drug nanoparticles: Effects of the lactose carrier particle shape and size", Int. J. Pharmaceutics, 233, 303-311, 2013. Link.
2012
- Y. Yang, W.S. Cheow, K. Hadinoto*, "Dry powder formulation of lipid-polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles", Int. J. Pharmaceutics, 434, 49-58, 2012. Link.
- W.S. Cheow, K. Hadinoto*, "Green Amorphous Nanoplex as a New Supersaturating Drug Delivery System", Langmuir, 28, 6265-6275, 2012. Link.
- W.S. Cheow, K. Hadinoto*, "Self-Assembled Amorphous Drug-Polyelectrolyte Nanoparticle Complex with Enhanced Dissolution Rate and Saturation Solubility", J Colloids and Interface Science, 367, 518-526, 2012. Link.
- W.S. Cheow, K. Hadinoto*, "Green preparation of antibiotic nanoparticle complex as potential anti-biofilm therapeutics via self-assembly amphiphile-polyelectrolyte complexation with dextran sulfate", Colloids and Surfaces B: Biointerfaces, 92, 55-63, 2012. Link.
- Y. Wang, K. Kho, W.S. Cheow, K. Hadinoto*, "A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid–polymer hybrid nanoparticles", Int. J. Pharmaceutics, 424, 98-106, 2012. Link.
- W.S. Cheow, K. Hadinoto*, "Lipid−Polymer Hybrid Nanoparticles with Rhamnolipid−Triggered Release Capability as Anti−Biofilm Drug Delivery Vehicles", Particuology, 10, 327-333, 2012. Link.
- J.Y.T. Tay, J.W. Chew, K. Hadinoto*, "Analyzing Minimum Entrainment Velocity of Ternary Particle Mixtures in Horizontal Pneumatic Transport", Ind. Eng. Chem. Res., 51, 5626-5632, 2012. Link
2011
- W.S. Cheow, K. Hadinoto*, "Factors Affecting Drug Encapsulation and Stability of Lipid-Polymer Hybrid Nanoparticles", Colloids and Surfaces B: Biointerfaces, 85, 214-220, 2011. Link
- W.S. Cheow, M.W. Chang, K. Hadinoto*, "The Roles of Lipid in Anti−Biofilm Efficacy of Lipid−Polymer Hybrid Nanoparticles Encapsulating Antibiotics", Colloids and Surfaces A: Physicochemical and Engineering Aspects, 389, 158-165, 2011. Link.
- W.S. Cheow, M.L.L. Ng, K. Kho, K. Hadinoto*, "Spray-Freeze-Drying Production of Thermally Sensitive Polymeric Nanoparticles Aggregates for Inhaled Drug Delivery: Effect of Freeze Drying Adjuvants", Int. J. Pharmaceutics, 404, 283-300, 2011. Link
- K. Kho, K. Hadinoto*, "Optimizing Aerosolization Efficiency of Dry-Powder Aggregates of Thermally-Sensitive Polymeric Nanoparticles Produced by Spray-Freeze-Drying", Powder Technol., 214, 169-176, 2011. Link
- S.P. Goy, J.W. Chew, K. Hadinoto*, "Effects of Binary Particle Size Distribution on Minimum Pick-Up Velocity in Pneumatic Conveying", Powder Technol., 208, 166-174, 2011. Link
- T. Chen*, K. Hadinoto, W. Yan, Y. Ma, "Efficient Meta Modeling of Complex Process Simulation with Time-Space Dependent Outputs", Comput. Chem. Eng., 35, 502-509, 2011. Link
2010
- W.S. Cheow, M.W. Chang, K. Hadinoto*, "Antibacterial Efficacy of Inhalable Levofloxacin-Loaded Polymeric Nanoparticles against E. Coli Biofilm Cells: The Effect of Antibiotic Release Profile", Pharm. Research, 27 (8), 1597-1609, 2010. Link
- W.S. Cheow, K. Hadinoto*, "Enhancing Encapsulation Efficiency of Highly Water-Soluble Antibiotic in Poly(lactic-co-glycolic acid) Nanoparticles: Modifications of Standard Nanoparticle Preparation Methods", Colloid Surface A: Physicochemical and Engineering Aspects, 370, 79-86, 2010. Link
- K. Kho, K. Hadinoto*, "Effect of Excipient Formulation on the Morphology and Aqueous Re-Dispersibility of Dry Powder Silica Nano-Aggregates", Colloid Surface A: Physicochemical and Engineering Aspects, 359, 71-81, 2010. Link
- K. Kho, W.S. Cheow, R.H. Lie, K. Hadinoto*, "Aqueous Re-Dispersibility of Spray-Dried Antibiotic-loaded Polycaprolactone Nanoparticle Aggregates for Inhaled Anti-Biofilm Therapy", Powder Technol., 203, 432-439, 2010. Link
- K. Kho, K. Hadinoto*, "Aqueous Re-Dispersibility Characterization of Spray-Dried Hollow Spherical Silica Nano-Aggregates", Powder Technol., 198, 354-363, 2010. Link
- W.S. Cheow, M.W. Chang, K. Hadinoto*, "Antibacterial Efficacy of Inhalable Antibiotic-Encapsulated Biodegradable Polymeric Nanoparticles against E. coli Biofilm Cells", J. Biomed. Nanotechnol., 6, 391-403, 2010. Link
- W.S. Cheow, S. Li, K. Hadinoto*, "Spray Drying Formulation of Hollow Spherical Aggregates of Silica Nanoparticles by Experimental Design", Chem. E. Res. Design, 88, 673-685, 2010. Link
- K. Hadinoto*, "Predicting Turbulence Modulations at Different Reynolds Numbers in Dilute-Phase Turbulent Liquid-Particle Flow Simulation", Chem. Eng. Sci., 65, 5297-5308, 2010. Link
- K. Hadinoto*, J.W. Chew, "Modeling Fluid-Particle Interaction in Dilute-Phase Turbulent Liquid-Particle Flow Simulation", Particuology, 8, 150-160, 2010. Link
2009 and older
- K. Hadinoto*, "Mechanical Stability of Hollow Spherical Nano-Aggregates as Ultrasound Contrast Agent", Int. J. Pharmaceutics, 374, 153-161, 2009. Link
- K. Hadinoto*, W.S. Cheow, "Hollow Spherical Nanoparticulate Aggregates as Potential Ultrasound Contrast Agent: Shell Thickness Characterization", Drug Dev. Ind. Pharmacy, 35(10), 1167-1179, 2009. Link
- K. Hadinoto*, K.W. Zhu, R.B.H. Tan, "Drug Release Study of Large Hollow Nanoparticulate Aggregates Carrier Particles for Pulmonary Delivery", Int. J. Pharmaceutics, 341, 195-206, 2007. Link
- K. Hadinoto*, P. Phanapavudhikul, K.W. Zhu, R.B.H. Tan, "Dry Powder Aerosol Delivery of Large Hollow Nanoparticulate Aggregates as Prospective Carriers of Nanoparticulate Drugs: Effects of Phospholipids", Int. J. Pharmaceutics,333 (1-2), 187-198, 2007. Link
- K.W. Zhu, R.B.H. Tan, F.X. Chen, K. Hadinoto, P.W.S. Heng, "Influence of Particle Wall Adhesion on Particle Electrification in Mixers", Int. J. Pharmaceutics, 328 (1), 22-34, 2007. Link
- K. Hadinoto*, P. Phanapavudhikul, K.W. Zhu, R.B.H. Tan, "Novel Formulation of Large Hollow Nanoparticles Aggregates as Potential Carriers in Inhaled Delivery of Nanoparticulate Drugs", Ind. E. Chem. Research, 45, 3697-3706, 2006. Link
- K. Hadinoto*, J.S. Curtis, "Numerical Simulation of Reynolds Number Effect on Gas-Phase Turbulent Modulation", Int. J. Multiphase Flow, 35(2), 129-141, 2009. Link
- K. Hadinoto*, J.S. Curtis, "Numerical Simulation of Turbulent Particle-Laden Flows with Significant Fluid to Particle Inertia Ratio", Ind. E. Chem. Research, 48(12), 5874-5884, 2009. Link
- K. Hadinoto*, J.S. Curtis, "Reynolds Number Dependence of Gas-Phase Turbulence in Particle-Laden Flows: Effect of Particle Inertia and Particle Loading", Powder Technol., 195(2), 119-127, 2009. Link
- K. Hadinoto*, E.N. Jones, C. Yurteri, J.S. Curtis, "Reynolds Number Dependence of Gas-Particle Turbulence in Gas-Particle Flows", Int. J. Multiphase Flow, 31, 416-434, 2005. Link
- K. Hadinoto, J.S. Curtis, "Effect of Interstitial Fluid on Particle-Particle Interactions in Kinetic Theory Approach of Dilute Turbulent Fluid-Particle Flow", Ind. E. Chem. Research, 43, 3604-3615, 2004. Link