Particle Technology Lab

Publications

Book Chapter

  1. W.S. Cheow and K. Hadinoto, "Antibiotic Polymeric Nanoparticles for Biofilm-Associated Infection Therapy". In G. Donelli (Ed.), Microbial Biofilms - Methods and Protocols, 2014. Humana Press. Link.

Journal papers

2018

  1. T.T. Tran,C. Vidaillac, H. Yu, V. Yong, D. Roizman, R. Chandrasekaran, A.Y.H. Lim, T.B. Low. G.L. Tan, J.A. Abisheganaden, M. Koh, J. Teo, S.H. Chotirmall, K. Hadinoto*, ”A new therapeutic avenue for bronchiectasis: Dry powder inhaler of ciprofloxacin nanoplex exhibits superior ex vivo mucus permeability and antibacterial efficacy to its native ciprofloxacin counterpart“, Int. J. Pharmaceutics , 547, 368-376,2018.
  2. L.M. Lim,T.T. Tran,J.J.L. Wong,D. Wang,W.S.Cheow, K. Hadinoto*, ”Amorphous ternary nanoparticle complex of curcumin-chitosan-hypromellose exhibiting built-in solubility enhancement and physical stability of curcumin“, Colloids Surf. B , 167, 483-491,2018.
  3. J.J.L. Wong, H. Yu, L.M. Lim, K. Hadinoto*, ”A trade-off between solubility enhancement and physical stability upon simultaneous amorphization and nanonisation of curcumin in comparison to amorphization alone“, Eur. J. Pharm. Sci. , 114, 356-363,2018.
  4. K.N. Khaqqi, J.J. Sikorski, K. Hadinoto*,M. Kraft, ”Incorporating seller/buyer reputation-based system in blockchain-enabled emission trading application“, Applied Energy ,209, 8-19, 2018.
  5. J.J.L. Wong, H. Yu, K. Hadinoto*, ”Examine practical feasibility of amorphous curcumin-chitosan nanoparticle complex as solubility enhancement strategy of curcumin: Scaled-up production, dry powder transformation, and long-term physical stability“, Colloids Surf. A ,537, 36-43, 2018.
  6. H. Yu, M.H. Nguyen, K. Hadinoto*, ”Effects of chitosan molecular weight on the physical and dissolution characteristics of amorphous curcumin-chitosan nanoparticle complex“, Drug Dev. Ind. Pharm. ,44, 82-88, 2018.

2017

  1. L.M. Lim, T.T. Tran, W.S. Cheow, K. Hadinoto*, ”Re-evaluating the presumed superiority of amorphous nanoparticles over amorphous microscale solid dispersion in solubility enhancement of poorly soluble drugs“, Eur. J. Pharm. Sci. , 109, 455-463, 2017.
  2. M.H. Nguyen, N.D. Pham, B.X. Dong, T.H.N. Nguyen, C.B. Bui, K. Hadinoto*, ”Radioprotection activités of curcumin-encapsulated liposomes against genotoxicity caused by Gamma-Cobalt-60 irradiation in human blood cells“, Int. J. Radiation Biol. , 93(11), 1267-1273, 2017.
  3. H. Yu, K. Hadinoto*, ”Impact of dextran sulphate’s chain length on the characteristics of its self-assembled colloidal complex formed with amphiphilic small-molecule drug“, Int. J. Bio. Macromolecules. , 103, 493-500, 2017.
  4. H. Yu, M.H. Nguyen, W.S. Cheow, K. Hadinoto*, ”A new bioavailability enhancement strategy of curcumin via self-assembly nano-complexation of curcumin and bovine serum albumin“, Mat. Sci. Engr. C, 75, 25-33, 2017.
  5. B.X. Dong, K. Hadinoto*, ”Amorphous nanoparticle complex of perphenazine and dextran sulphate as a new solubility enhancement strategy of antipsychotic perphenazine“, Drug Dev. Ind. Pharm. , 43(6), 996-1002, 2017.
  6. B.X. Dong, K. Hadinoto*, ”Direct comparison between millifluidics and bulk-mixing platform in the synthesis of amorphous drug-polysaccharide nanoparticle complex“, Int. J. Pharm. , 523, 42-51, 2017.
  7. T.T. Tran, K. Hadinoto*, ”A new solubility enhancement strategy of capsaicin in the form of high-payload submicron capsaicin-chitosan colloidal complex“, Colloids Surf. A, 520, 62-71, 2017.
  8. T.T. Tran, M.H. Nguyen, Y.Z. Tan, J.W. Chew, S.A. Khan, K. Hadinoto*, ”Millifluidic synthesis of amorphous drug-polysaccharide nanoparticle complex with tunable size intended for supersaturating drug delivery applications“, Eur. J. Pharm. Biopharm. , 112, 196-203, 2017.
  9. Q.L.Lei, K. Hadinoto*, R. Ni*, ”Complexation of polyelectrolytes with hydrophobic drug molecules in salt-free solution: Theory and Simulations“, Langmuir , 33(15), 3900-3909, 2017.
  10. Q.L.Lei, K. Hadinoto, R. Ni*, ”Role of local assembly in the hierarchical crystallisation of associating colloidal hard hemispheres“, Phys. Rev. Mat. , 1(5), 052601, 2017.

2016

  1. H. Yu, T.T. Tran, J. Teo, and K. Hadinoto*, "Dry powder aerosols of curcumin-chitosan nanoparticle complex prepared by spray freeze drying and their antimicrobial efficacy against common respiratory bacterial pathogens", Colloids Surf. A , 504, 34-42, 2016.
  2. M.H. Nguyen, H. Yu, B.X. Dong, and K. Hadinoto*, "A supersaturating delivery system of silibinin exhibiting high payload achieved by amorphous nano-complexation with chitosan", Eur. J. Pharm. Sci. , 89, 163-171, 2016. Link.
  3. M.H. Nguyen, T.T. Tran, and K. Hadinoto*, "Controlling the burst release of amorphous drug-polysaccharide nanoparticle complex via crosslinking of the polysaccharide chains", Eur. J. Pharm. Biopharm. , 104, 156-163, 2016 Link.
  4. H. Yu, J. Teo, J.W. Chew and K. Hadinoto*, "Dry powder inhaler formulation of high-payload antibiotic nanoparticle complex intended for bronchiectasis therapy: spray drying versus spray freeze drying preparation", Int. J. Pharmaceutics , 499, 38-46, 2016. Link.
  5. A. Anantharaman, A. Cahyadi, K. Hadinoto, J.W. Chew, "Impact of particle diameter, density, and sphericity on minimum pick-up velocity of binary mixtures in gas-solid pneumatic conveying", Powder Technol. , 297, 311-319, 2016. Link.
  6. W.S. Cheow, T.Y. Kiew and K. Hadinoto*, "Effect of adding resistant and waxy starches on cell density and survival of encapsulated biofilm of Lactobacillus rhamnosus GG probiotics", LWT Food Sci. and Technol. 69, 497-505, 2016. Link.

2015

  1. W.S. Cheow, T.Y. Kiew, and K. Hadinoto*, "Combining inkjet printing and amorphous nanonization to prepare personalized dosage forms of poorly-soluble drugs", Eur. J. Pharm. Biopharm. , 96, 314-321, 2015. Link.
  2. M.H. Nguyen, H. Yu, T.Y. Kiew, and K. Hadinoto*, "Cost-effective alternative to nano-encapsulation: Amorphous curcumin-chitosan nanoparticle complex exhibiting high payload and supersaturation generation", Eur. J. Pharm. Biopharm. , 96, 1-10, 2015. Link.
  3. A. Anantharaman, X. Wu, K. Hadinoto, J.W. Chew, "Impact of continuous particle size distribution width and particle sphericity on minimum pick-up velocity in gas-solid pneumatic conveying", Chem. Engr. Sci, 130 (7), 92-100, 2015. Link.
  4. H. Yu and K. Hadinoto*, "Mitigating the adverse effect of spray drying on the supersaturation generation capability of amorphous nanopharmaceutical powders", Powder Technol. , 277, 97-104, 2015. Link.
  5. M. Kutscher, W.S. Cheow, V. Werner, U. Lorentz, K. Ohlsen, L. Meinel, K. Hadinoto, O. Germershaus, "Influence of salt type and ionic strength on the self-asembling of polyelectrolyte-drug nanoplexes", Int. J. Pharmaceutics, 486, 21-29, 2015. Link.
  6. T.Y. Kiew, W.S. Cheow, and K. Hadinoto*, "Preserving the supersaturation generation capability of amorphous drug-polysaccharide nanoparticle complex after freeze drying", Int. J. Pharmaceutics, 484, 115-123, 2015. Link.
  7. K.Y. Lim, R.Y. Chua, B. Ho, P.A. Tambyah, K. Hadinoto*, S.S.J. Leong, "Development of a catheter functionalized by a polyphodamine-peptide coating with antimicrobial and anti-biofilm properties", Acta Biomater.,15,127-138,2015. Link.
  8. W.S. Cheow, T.Y. Kiew, and K. Hadinoto*, "Amorphous nanodrugs prepared by complexation with polysaccharides: Carrageenan versus Dextran Sulfate", Carbohydr. Polym. 117, 549-558, 2015. Link.

2014

  1. K. Hadinoto* and Y. Yang, "Continuous and sustainable granulation of nanopharmaceuticals via spray coagulation encapsulation in alginate", Int. J. Pharmaceutics, 473 (1-2), 644-652, 2014. Link.
  2. T.Y. Kiew, W.S. Cheow, and K. Hadinoto*, "Importance of biofilm age and growth medium on the viability of probiotic capsules containing Lactobacillus rhamnosus biofilm", LWT Food Sci. and Technol. 59(2), 956-963, 2014. Link.
  3. W.S. Cheow, T.Y. Kiew, Y. Yang and K. Hadinoto*, "Amorphization strategy affects the stability and supersaturation profile of amorphous drug nanoparticles", Mol. Pharmaceut. 11(5), 1611-1620, 2014. Link.
  4. K. Hadinoto* and W.S. Cheow, "Nano-antibiotics in chronic lung infection therapy against Pseudomonas aeruginosa", Colloid Surface B. 116, 772-785, 2014. Link.
  5. W.S. Cheow, T.Y. Kiew and K. Hadinoto*, "Controlled release of Lactobacillus rhamnosus biofilm probiotics from alginate-locust bean gum microcapsules", Carbohydr. Polym, 103,587-595, 2014. Link.

2013

  1. W.S. Cheow and K. Hadinoto*, "Biofilm-Like Lactobacillus rhamnosus Probiotics Encapsulated in Alginate and Carrageenan Microcapsules Exhibiting Enhanced Thermotolerance and Freeze Drying Resistance", Biomacromolecules, 19,3214-3222, 2013. Link.
  2. K. Hadinoto*, A. Sundaresan, and W.S. Cheow, "Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review", Eur. J. Pharm. Biopharm, 85,427-443, 2013. Link.
  3. Y. Yang and K. Hadinoto*, "A Highly Sustainable and Versatile Granulation Method of Nanodrugs via Their Electrostatic Adsorption onto Chitosan Microparticles as the Granulation Substrates ", Int. J. Pharmaceutics, 452,402-411, 2013. Link.
  4. W.S. Cheow, R. Xu, and K. Hadinoto*, "Towards Sustainability: New Approaches to Nano-Drug Preparation", Curr. Pharm. Design, 19,6229-6245, 2013. Link.
  5. K. Kho and K. Hadinoto*, "Dry powder inhaler delivery of amorphous drug nanoparticles: Effects of the lactose carrier particle shape and size", Int. J. Pharmaceutics, 233, 303-311, 2013. Link.

2012

  1. Y. Yang, W.S. Cheow, K. Hadinoto*, "Dry powder formulation of lipid-polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles", Int. J. Pharmaceutics, 434, 49-58, 2012. Link.
  2. W.S. Cheow, K. Hadinoto*, "Green Amorphous Nanoplex as a New Supersaturating Drug Delivery System", Langmuir, 28, 6265-6275, 2012. Link.
  3. W.S. Cheow, K. Hadinoto*, "Self-Assembled Amorphous Drug-Polyelectrolyte Nanoparticle Complex with Enhanced Dissolution Rate and Saturation Solubility", J Colloids and Interface Science, 367, 518-526, 2012. Link.
  4. W.S. Cheow, K. Hadinoto*, "Green preparation of antibiotic nanoparticle complex as potential anti-biofilm therapeutics via self-assembly amphiphile-polyelectrolyte complexation with dextran sulfate", Colloids and Surfaces B: Biointerfaces, 92, 55-63, 2012. Link.
  5. Y. Wang, K. Kho, W.S. Cheow, K. Hadinoto*, "A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid–polymer hybrid nanoparticles", Int. J. Pharmaceutics, 424, 98-106, 2012. Link.
  6. W.S. Cheow, K. Hadinoto*, "Lipid−Polymer Hybrid Nanoparticles with Rhamnolipid−Triggered Release Capability as Anti−Biofilm Drug Delivery Vehicles", Particuology, 10, 327-333, 2012. Link.

  7. J.Y.T. Tay, J.W. Chew, K. Hadinoto*, "Analyzing Minimum Entrainment Velocity of Ternary Particle Mixtures in Horizontal Pneumatic Transport", Ind. Eng. Chem. Res., 51, 5626-5632, 2012. Link

2011

  1. W.S. Cheow, K. Hadinoto*, "Factors Affecting Drug Encapsulation and Stability of Lipid-Polymer Hybrid Nanoparticles", Colloids and Surfaces B: Biointerfaces, 85, 214-220, 2011. Link
  2. W.S. Cheow, M.W. Chang, K. Hadinoto*, "The Roles of Lipid in Anti−Biofilm Efficacy of Lipid−Polymer Hybrid Nanoparticles Encapsulating Antibiotics", Colloids and Surfaces A: Physicochemical and Engineering Aspects, 389, 158-165, 2011. Link.
  3. W.S. Cheow, M.L.L. Ng, K. Kho, K. Hadinoto*, "Spray-Freeze-Drying Production of Thermally Sensitive Polymeric Nanoparticles Aggregates for Inhaled Drug Delivery: Effect of Freeze Drying Adjuvants", Int. J. Pharmaceutics, 404, 283-300, 2011. Link
  4. K. Kho, K. Hadinoto*, "Optimizing Aerosolization Efficiency of Dry-Powder Aggregates of Thermally-Sensitive Polymeric Nanoparticles Produced by Spray-Freeze-Drying", Powder Technol., 214, 169-176, 2011. Link
  5. S.P. Goy, J.W. Chew, K. Hadinoto*, "Effects of Binary Particle Size Distribution on Minimum Pick-Up Velocity in Pneumatic Conveying", Powder Technol., 208, 166-174, 2011. Link
  6. T. Chen*, K. Hadinoto, W. Yan, Y. Ma, "Efficient Meta Modeling of Complex Process Simulation with Time-Space Dependent Outputs", Comput. Chem. Eng., 35, 502-509, 2011. Link


2010

  1. W.S. Cheow, M.W. Chang, K. Hadinoto*, "Antibacterial Efficacy of Inhalable Levofloxacin-Loaded Polymeric Nanoparticles against E. Coli Biofilm Cells: The Effect of Antibiotic Release Profile", Pharm. Research, 27 (8), 1597-1609, 2010. Link
  2. W.S. Cheow, K. Hadinoto*, "Enhancing Encapsulation Efficiency of Highly Water-Soluble Antibiotic in Poly(lactic-co-glycolic acid) Nanoparticles: Modifications of Standard Nanoparticle Preparation Methods", Colloid Surface A: Physicochemical and Engineering Aspects, 370, 79-86, 2010. Link

  3. K. Kho, K. Hadinoto*, "Effect of Excipient Formulation on the Morphology and Aqueous Re-Dispersibility of Dry Powder Silica Nano-Aggregates", Colloid Surface A: Physicochemical and Engineering Aspects, 359, 71-81, 2010. Link
  4. K. Kho, W.S. Cheow, R.H. Lie, K. Hadinoto*, "Aqueous Re-Dispersibility of Spray-Dried Antibiotic-loaded Polycaprolactone Nanoparticle Aggregates for Inhaled Anti-Biofilm Therapy", Powder Technol., 203, 432-439, 2010. Link

  5. K. Kho, K. Hadinoto*, "Aqueous Re-Dispersibility Characterization of Spray-Dried Hollow Spherical Silica Nano-Aggregates", Powder Technol., 198, 354-363, 2010. Link

  6. W.S. Cheow, M.W. Chang, K. Hadinoto*, "Antibacterial Efficacy of Inhalable Antibiotic-Encapsulated Biodegradable Polymeric Nanoparticles against E. coli Biofilm Cells", J. Biomed. Nanotechnol., 6, 391-403, 2010. Link
  7. W.S. Cheow, S. Li, K. Hadinoto*, "Spray Drying Formulation of Hollow Spherical Aggregates of Silica Nanoparticles by Experimental Design", Chem. E. Res. Design, 88, 673-685, 2010. Link
  8. K. Hadinoto*, "Predicting Turbulence Modulations at Different Reynolds Numbers in Dilute-Phase Turbulent Liquid-Particle Flow Simulation", Chem. Eng. Sci., 65, 5297-5308, 2010. Link

  9. K. Hadinoto*, J.W. Chew, "Modeling Fluid-Particle Interaction in Dilute-Phase Turbulent Liquid-Particle Flow Simulation", Particuology, 8, 150-160, 2010. Link


2009 and older

  1. K. Hadinoto*, "Mechanical Stability of Hollow Spherical Nano-Aggregates as Ultrasound Contrast Agent", Int. J. Pharmaceutics, 374, 153-161, 2009. Link
  2. K. Hadinoto*, W.S. Cheow, "Hollow Spherical Nanoparticulate Aggregates as Potential Ultrasound Contrast Agent: Shell Thickness Characterization", Drug Dev. Ind. Pharmacy, 35(10), 1167-1179, 2009. Link
  3. K. Hadinoto*, K.W. Zhu, R.B.H. Tan, "Drug Release Study of Large Hollow Nanoparticulate Aggregates Carrier Particles for Pulmonary Delivery", Int. J. Pharmaceutics, 341, 195-206, 2007. Link
  4. K. Hadinoto*, P. Phanapavudhikul, K.W. Zhu, R.B.H. Tan, "Dry Powder Aerosol Delivery of Large Hollow Nanoparticulate Aggregates as Prospective Carriers of Nanoparticulate Drugs: Effects of Phospholipids", Int. J. Pharmaceutics,333 (1-2), 187-198, 2007. Link
  5. K.W. Zhu, R.B.H. Tan, F.X. Chen, K. Hadinoto, P.W.S. Heng, "Influence of Particle Wall Adhesion on Particle Electrification in Mixers", Int. J. Pharmaceutics, 328 (1), 22-34, 2007. Link

  6. K. Hadinoto*, P. Phanapavudhikul, K.W. Zhu, R.B.H. Tan, "Novel Formulation of Large Hollow Nanoparticles Aggregates as Potential Carriers in Inhaled Delivery of Nanoparticulate Drugs", Ind. E. Chem. Research, 45, 3697-3706, 2006. Link

  7. K. Hadinoto*, J.S. Curtis, "Numerical Simulation of Reynolds Number Effect on Gas-Phase Turbulent Modulation", Int. J. Multiphase Flow, 35(2), 129-141, 2009. Link

  8. K. Hadinoto*, J.S. Curtis, "Numerical Simulation of Turbulent Particle-Laden Flows with Significant Fluid to Particle Inertia Ratio", Ind. E. Chem. Research, 48(12), 5874-5884, 2009. Link

  9. K. Hadinoto*, J.S. Curtis, "Reynolds Number Dependence of Gas-Phase Turbulence in Particle-Laden Flows: Effect of Particle Inertia and Particle Loading", Powder Technol., 195(2), 119-127, 2009. Link

  10. K. Hadinoto*, E.N. Jones, C. Yurteri, J.S. Curtis, "Reynolds Number Dependence of Gas-Particle Turbulence in Gas-Particle Flows", Int. J. Multiphase Flow, 31, 416-434, 2005. Link
  11. K. Hadinoto, J.S. Curtis, "Effect of Interstitial Fluid on Particle-Particle Interactions in Kinetic Theory Approach of Dilute Turbulent Fluid-Particle Flow", Ind. E. Chem. Research, 43, 3604-3615, 2004. Link